Non-significant association between − 330 T/G polymorphism in interleukin-2 gene and chronic periodontitis: findings from a meta-analysis

Abstract

Background Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data. Methods A literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I2) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg’ and Egger’s test with Comprehensive meta-analysis software. The value of P < 0.05 was considered as significant. Results Five studies were identified in diverse ethnical groups with 1425 participants. The − 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg’s test and the linear regression Egger’s test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic. Conclusions This meta-analysis showed a non-significant association between − 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation.

Relationship between the rs333 Polymorphism in the CC Chemokine Receptor Type Five (CCR5) Gene and Immunological Disorders: Data from a Meta-Analysis

“…Sixth, we have evaluated one single polymorphism, other genetic variations may influence the rs1333 role in these inflammatory conditions. Previous studies available in the literature already showed the considerable impact of genetic polymorphisms and IBD [73], periodontitis [74][75][76][77][78][79] and SLE [80,81] further studies are required to validate our results.…”

Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review

“…In a case-control study, the higher frequencies of the IL2 (+166, −330) haplotype were observed in patients with chronic periodontitis, when compared to controls of a mixed population [56]. In a recent meta-analysis, though, a non-significant association between 330 T/G polymorphism in the IL2 gene and chronic periodontitis, in any allelic evaluation, was reported [57].…”

“…TGF-β is a family of polypeptide growth factors involved in the inflammatory process and in regulation of the immune response [80]. Elevated TGF-β1 levels were found in patients with periodontitis, both in gingival tissue and in gingival fluid [57]. However, to date, no relationship has been found between the occurrence of chronic periodontitis and TGF-β1 encoding gene polymorphisms: −509 (C → T), −800 (G → A), −988 (C → A), +869 (T → C) and +915 (G → C) [80].…”

Causal relationships between inflammatory factors and Periodontitis: A bidirectional Mendelian randomization study

“…Recent literature surveys have revealed con icting outcomes regarding the relationship between in ammatory factors and periodontitis. For example, one study found a correlation between IL-2 gene promoter polymorphisms and periodontitis [14] , while others proposed that IL-2 promoter gene polymorphisms might not be linked to susceptibility to periodontitis [15] . As a result, a comprehensive elucidation of the in ammatory factors in uencing the risk of periodontitis and their respective contributions is still necessary.…”