2010
DOI: 10.3121/cmr.2010.958
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Non-Rural Point Source Blastomycosis Outbreak Near a Yard Waste Collection Site

Abstract: Background: Blastomycosis is a potentially fatal infection caused by the fungus Blastomyces dermatitidis.During January 1 through March 5, 2006, twenty-one laboratory confirmed cases of blastomycosis were reported among residents of an endemic area in north-central Wisconsin; a striking increase compared with previous years. The objective of the study was to determine if an observed increase in blastomycosis among residents of an urban area in north-central Wisconsin was caused by a pointsource exposure and to… Show more

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Cited by 40 publications
(32 citation statements)
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“…Furthermore, like B. gilchristii (PS2), genotypic group A isolates showed an analogous geographic distribution and lacked genetic variation compared with other genotypes [33]. Interestingly, two separate outbreak investigations in Wisconsin have identified genotypic group A as the predominant organism isolated from patients [33], [71]. Similarly, B. gilchristii (PS2) was responsible for the majority of Wisconsin and northwestern Ontario cases in our analysis.…”
Section: Discussionmentioning
confidence: 54%
See 1 more Smart Citation
“…Furthermore, like B. gilchristii (PS2), genotypic group A isolates showed an analogous geographic distribution and lacked genetic variation compared with other genotypes [33]. Interestingly, two separate outbreak investigations in Wisconsin have identified genotypic group A as the predominant organism isolated from patients [33], [71]. Similarly, B. gilchristii (PS2) was responsible for the majority of Wisconsin and northwestern Ontario cases in our analysis.…”
Section: Discussionmentioning
confidence: 54%
“…In these areas, incidence rates exceed 100 cases per 100 000 with documented outbreaks [28], [60], [68], [70], [71]. Genetic analysis of B. gilchristii (PS2) isolates demonstrated low levels of genetic diversity with only 7 unique sequence types encompassing 8 unique polymorphisms in 39 isolates.…”
Section: Discussionmentioning
confidence: 99%
“…We did not test for associations between genetic group and nonhuman host species, due to the lack of statistical power to detect differences. Interestingly, isolates obtained from patients and the environment that were identified during documented outbreak investigations (16,17,32) all clustered within genetic group 1. Although the number of isolates in this category is small (n ϭ 18) (Table 1), it may indicate phenotypic differences between the two groups related to infectivity and/or virulence.…”
Section: Discussionmentioning
confidence: 99%
“…Case series and outbreak reports have provided insight into the ecology of Blastomyces spp. and possible risk factors for human infection (16)(17)(18)(19). Outbreaks have been associated with outdoor recreation (17,(20)(21)(22) and with construction, excavation, or local environmental sources such as yard waste compost (18).…”
mentioning
confidence: 99%