Non-pharmacological therapeutic strategy options for patients with dementia based on cognitive function—A Bayesian network meta-analysis of randomized controlled trials

Liang, Jinghong; Lü, Lin; Wang, Yingquan; Jia, Rui‐xia; Qü, Xia; Li, Jing; Li, Jia-Yu; Shen, Qian; Qian, Yufeng; Wang, Shan; Gao, Zhen; Cheng, Xingxue; Xu, Yong

doi:10.1016/j.arr.2019.100965

Cited by 10 publications

(8 citation statements)

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“…In fact, results from a collection of studies imply that a PA intervention is potentially more suitable for adults than for youth as it is originally intended for the former (Verburgh et al, 2014). As has been mentioned, previous trials described that PA demonstrates its effect not only on different populations but also on various diseases such as dementia, diabetes, and Parkinson's (Goodwin et al, 2008;Liang et al, 2019;Wu et al, 2019). Despite the fact that our results revealed no significant relationship between PA and ADHD, a similar study drew the conclusion that PA had significantly improved a variety of behaviors and social problems among children affected by ADHD (Zang, 2019).…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis and systematic review of physical activity on neurodevelopment disorders, depression, and obesity among children and adolescents

et al. 2022

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BackgroundNo consensus on whether physical activity (PA) is related to physical and mental health among pediatric population remains has been reached to date. To further explore their association, our study assessed the effect of PA on physical and mental health of children and adolescents through a systematic review and meta-analysis of randomized controlled studies (RCTs).MethodsSeveral databases(Web of science, PubMed, Embase, Cochrane Central register of controlled trials, CINAHL) were searched from inception to 1st, December 2020 without language restrictions.Results38,236 records were identified primitively and 31 included studies with 1,255 participants eventually met our inclusion criteria, all of which exhibited a relatively low-moderate risk of bias of overall quality. In regard to mental health, the administration of PA, compared with the control group, led to moderate improvements in Autism Spectrum Disorder(ASD)[Standard mean difference (SMD) = −0.50, Confidence interval(CI): −0.87, −0.14)] and depression(SMD = −0.68, CI: −0.98, −0.38) among children and adolescents. Similarly, significant result was observed in obesity (SMD = −0.58, CI: −0.80, −0.36). No significant differences were observed in Attention deficit hyperactivity disorder (ADHD) (SMD = −0.29, CI: −0.59, 0.01).ConclusionAltogether, PA may have a beneficial effect on children and adolescents with ASD, depression and obesity; nevertheless, there is insufficient evidence to confirm its efficacy in ADHD. More large-scale population based randomized controlled trials are needed to explore more reliable evidence between them.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis and systematic review of physical activity on neurodevelopment disorders, depression, and obesity among children and adolescents

et al. 2022

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“…In contrast, non-pharmacological therapies (NPTs), which aimed at improving dementia in the elderly, had attracted considerable attention due to their safe, relatively inexpensive, and scalable intervention. At present, the routine NPTS research on dementia patients showed that exercise therapy (ET), cognitive stimulation therapy (CST), and computerized cognitive training (CCT) indicate better treatment effects ( Liang et al, 2019 ). And enriched environment (EE) and photobiomodulation (PBM), as new treatment modalities, have shown sound therapeutic effects in recent studies ( Bourdon and Belmin, 2021 ; Salehpour et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of non-pharmacological therapies on cognitive function in patients with dementia—A network meta-analysis of randomized controlled trials

Luo

Zhang

Song

et al. 2023

Front. Aging Neurosci.

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ObjectiveNon-pharmacological therapies (NPTs) have received increasing attention from researchers as a category of treatment to improve cognitive impairment in patients with dementia because of their fewer side effects. In this study, photobiomodulation (PBM), enriched environment (EE), exercise therapy (ET), computerized cognitive training (CCT), and cognitive stimulation therapy (CST) were selected to compare the effects of NPTs that improve dementia by quantifying information from randomized controlled trials (RCTs).MethodsWe did a systematic review and network meta-analysis. We searched PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), China National Knowledge Infrastructure Database, Wan Fang Database, Chinese Biomedical Literature Database, Web of Science, and VIP Database from the time of database creation to 1 August 2022. Two investigators independently screened the literature, extracted information, and assessed the RCTs’ quality with the Cochrane Collaboration Network Risk of Bias 2.0. Network meta-analysis was performed using R language (X64 version 4.1.3) and STATA 17.0.ResultsWe identified 1,268 citations and of these included 38 trials comprising 3,412 participants. For improving dementia, the results of the network meta-analysis showed that compared with the control group (CON), PBM (SMD = 0.90, 95% CI: 0.43–1.37), EE (SMD = 0.71, 95% CI: 0.02–1.41), ET (SMD = 0.42, 95% CI: 0.16–0.68), and CST (SMD = 0.36, 95% CI: 0.11–0.62) were significantly different (P < 0.05); There was no significant difference in CCT (SMD = 0.41, 95% CI: −0.07–0.88) (P > 0.05). The ranked results showed that PBM has more potential to be the best intervention (P = 0.90). In addition, there was a significant difference between PBM and CST in improving cognitive function (SMD = 0.54, 95% CI: 0.00; 1.08, P < 0.05).ConclusionIn this study, NPTs have excellent potential to improve cognition in people with dementia, and PBM may have more significant benefits in improving cognition than the other four NPTs.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022363746.

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“…More commonly considered non-pharmacotherapies (NPTs) include cognitive stimulation, cognitive rehabilitation, music therapy, computerized cognitive training, exercise and noninvasive brain stimulation, which have been associated with improved cognitive function and related behaviors such as decreased agitation and depressed mood. [14][15][16][17][18][19] Currently, no disease-modifying treatments have proven fully effective in controlling the symptoms of AD. Despite focused research efforts on preclinical and early stage AD to develop new disease-modifying treatments that reduce the pathophysiological changes associated with AD [20] (i.e., amyloid deposition, phosphorylation and protein aggregation), no significant clinical effect have been achieved, to date.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis

et al. 2022

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Background: Alzheimer disease (AD) is the most common cause of dementia worldwide. Despite the publication of numerous systematic reviews and meta-analyses that have summarized the evidence associated with pharmacotherapies (PTs) and nonpharmacotherapies (NPTs) for the wide range of interventions available for AD treatment, their comparative safety and efficacy remains insufficiently defined.Methods: Systematic reviews of randomized controlled trials (RCTs) will be selected according to the following criteria: conducted in elderly patients aged 60 years or older with AD living in community or institutionalized settings, applied pairwise meta-analysis (PMA) or network meta-analysis (NMA) approaches providing pooled relative treatment effects for at least 1 pair of PTs or NPTs, and providing at least 1 of the following outcomes for patients/caregivers: cognitive, functional status, behavior, quality of life (QoL), and caregiver stress or burden. All article screening, data extraction, and risk of bias assessment will be completed independently by 2 reviewers. Relative treatment rankings will be reported with mean ranks and surface under the cumulative ranking curves. Results and Conclusion:We will determine the most efficacious treatment strategies for AD patients from the most highly ranked treatments. These results will help to guide clinical decision-making and improve patient care.

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Non-pharmacological therapeutic strategy options for patients with dementia based on cognitive function—A Bayesian network meta-analysis of randomized controlled trials

Cited by 10 publications

References 61 publications

Meta-analysis and systematic review of physical activity on neurodevelopment disorders, depression, and obesity among children and adolescents

Meta-analysis and systematic review of physical activity on neurodevelopment disorders, depression, and obesity among children and adolescents

Effectiveness of non-pharmacological therapies on cognitive function in patients with dementia—A network meta-analysis of randomized controlled trials

Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis

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