Efficacy of pharmacotherapy and non-pharmacotherapy of Alzheimer dementia: A protocol for systematic review and meta-analysis

Boongird, Chitima; Tearneukit, Worapong; Wongpipathpong, Wannisa; McKay, Gareth; Thakkinstian, Ammarin

doi:10.1097/md.0000000000032382

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…9 Currently, no disease-modifying treatments has been demonstrated to be fully effective in controlling the symptoms of dementia. 10 The effect of single-domain trials for people with dementia is still unclear. 11 Some positive benefits have been reported for physical activity-based interventions, cognitive training.…”

Section: Introductionmentioning

confidence: 99%

A Multidomain Intervention Program for Older People with Dementia: A Pilot Study

Nguyễn¹,

Vu²,

Nguyen³

et al. 2023

OAJCT

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Background: Multidomain interventions have been shown to be effective in improving cognition, quality of life, reducing neuropsychiatric symptoms and delaying progression of functional impairment or disability in dementia patients. To investigate the multidomain intervention in other populations and diverse cultural and geographical settings, this pilot study will assess the feasibility of a multidomain intervention for older people with dementia in nursing homes in Vietnam. Methods: Participants will be randomized into two equal groups, to receive either a multidomain intervention (intervention group) or regular health advice (control group). The intervention will include physical, cognitive, and social interventions as well as management of metabolic and vascular risk factors. We will hypothesize that the multidomain intervention will be feasible in Vietnam, and participants who receive the intervention will show improvement in quality of life, behaviors, functional ability, cognitive function, sleep, and in reduction of falls, use of healthcare services, and death rate compared to those in the control group during the 6 months intervention period and after the 6 months extended follow-up. Discussion: This is the first study to evaluate the feasibility of a multidomain intervention program for older people with dementia in nursing homes in Vietnam. The results from the trial will inform clinicians and the public of the possibility of comprehensive treatment beyond simply drug treatments for dementia. This paves the way for further studies to evaluate the long-term effects of multidomain interventions in dementia patients. Furthermore, the research results will provide information on the effectiveness of multidomain interventions which will inform policy development on dementia. Trial Registration: The trial is registered with ClinicalTrials.gov identifier: NCT04948450 on 02/07/2021.

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Section: Introductionmentioning

confidence: 99%