“…According to the 2016 Rome IV diagnostic criteria, the necessity of ruling out other underlying organic causes of abdominal pain using further testing and investigations is no longer required to make a diagnosis, provided the lack of red flags, such as family history of inflammatory bowel disease, celiac disease, peptic ulcer disease, persistent right upper or right lower quadrant pain, dysphagia, odynophagia, persistent vomiting, gastrointestinal bleeding, nocturnal diarrhea, arthritis, perirectal disease, involuntary weight loss, perirectal disease, deceleration of linear growth, delayed puberty and unexplained fever [7 ▪ ]. Thus, the evaluation through clinical criteria is considered adequate to make the diagnosis, provided the lack of alarming criteria to suggest a separate underlying cause.…”