“…Starting from the healthy state, an individual may enter an intermediate state before ending in death, or have transition directly to death. Applications can be found in animal carcinogenicity studies (Kodell and Nelson, 1980), medical studies involving human subjects, for example in HIV/AIDS research (Kalbfleisch and Lawless, 1989), and in industrial applications with machine faults (Dewanji and Dhar, 1993).…”