Non-Obese Diabetes and Its Associated Factors in an Underdeveloped Area of South China, Guangxi

Abstract

Background: Little research has been conducted on the prevalence of diabetes mellitus in underdeveloped areas in China, especially stratified into obesity and non-obese diabetes. The aim of the present study was to investigate the prevalence and associated factors of non-obese diabetes in an underdeveloped area in South China, Guangxi. Methods: Data derived from the Chinese Health and Nutrition Survey 2010–2012 involved a sample of 3874 adults from Guangxi. Questionnaires and oral glucose-tolerance tests were conducted, and fasting and 2-h glucose levels and serum lipids were measured. Logistic regression analysis was performed to assess associated factors for non-obese diabetes. Results: 68.2% and 62.2% of instances of newly detected diabetes were those of non-obese diabetes based on BMI (NODB) and based on WC (NODW), respectively. The male sex, an age older than 50 years, lower education, hypertension, and hypertriglyceridemia were significantly associated with a higher risk of both NODB and NODW, while some associated factors for NODB were found different from those associated with NODW, and an interaction effect was found to increase the risk of NODW. Conclusions: Our study indicated that non-obese diabetes was highly prevalent in an underdeveloped area of South China. Non-obese diabetes should be considered for increased public attention in these areas.

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“… 45 And another study reported that 68.2% of instances of newly detected T2D was those of non-obese T2D in southern China. 46 Compared with obese individuals, the key defect that causes the development of hyperglycemia in T2D in non-obese individuals is impaired pancreatic insulin secretion and decreased insulin resistance. 45 , 47 It is worth noting that the increased risk of cardiovascular disease in non-obese type 2 diabetic patients is similar to that of obese type 2 diabetic patients.…”

Trajectories of fasting glucose and glycated haemoglobin in obese and non‐obese incident diabetes: Results from two large cohort studies

“…3 For example, in some Asian countries, the proportion of non-obese diabetes accounted for over 60% of all diabetes cases. [4][5][6] Emerging evidence suggests that non-obese diabetes is associated with a higher risk of cardiovascular diseases than obese diabetes. [7][8][9] Moreover, several large-scale prospective cohort studies have found that non-obese diabetes is associated with an approximately two-fold higher risk of mortality than obese diabetes.…”

“…Obesity is a well‐established risk factor for type 2 diabetes (hereafter, diabetes) 1,2 ; however, a proportion of individuals develop diabetes in its absence 3 . For example, in some Asian countries, the proportion of non‐obese diabetes accounted for over 60% of all diabetes cases 4–6 . Emerging evidence suggests that non‐obese diabetes is associated with a higher risk of cardiovascular diseases than obese diabetes 7–9 .…”