Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

Hajj, Cynthia El; Walrand, Stéphane; Helou, Mariana; Yammine, Kaissar

doi:10.3390/nu12072033

Cited by 32 publications

(34 citation statements)

References 49 publications

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“…However, recent findings from randomized placebo trial data by Urbain et al, 2011 shows that button mushroom treated with UV-B can improve vitamin D2 bioavailability among human subjects, and the significant value does not differ with vitamin D2 supplements [96]. In addition, studies by Wenclewska et al, 2019;Mutt et al, 2020;Hajj et al, 2020;and Cojic et al, 2021 demonstrated the positive impact of vitamin D supplementation (2000IU and 30,000IU) on T2DM, which requires further trials [97][98][99][100]. Therefore, the question remains the exact mechanism and dose-dependent action of vitamin D on diabetes mellitus treatment.…”

Section: Role Of Vitamin D In Blood Glucose Regulationsmentioning

confidence: 99%

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Das

Chen

et al. 2022

Pharmaceutics

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Mushrooms belong to the family “Fungi” and became famous for their medicinal properties and easy accessibility all over the world. Because of its pharmaceutical properties, including anti-diabetic, anti-inflammatory, anti-cancer, and antioxidant properties, it became a hot topic among scientists. However, depending on species and varieties, most of the medicinal properties became indistinct. With this interest, an attempt has been made to scrutinize the role of edible mushrooms (EM) in diabetes mellitus treatment. A systematic contemporary literature review has been carried out from all records such as Science Direct, PubMed, Embase, and Google Scholar with an aim to represents the work has performed on mushrooms focuses on diabetes, insulin resistance (IR), and preventive mechanism of IR, using different kinds of mushroom extracts. The final review represents that EM plays an important role in anticipation of insulin resistance with the help of active compounds, i.e., polysaccharide, vitamin D, and signifies α-glucosidase or α-amylase preventive activities. Although most of the mechanism is not clear yet, many varieties of mushrooms’ medicinal properties have not been studied properly. So, in the future, further investigation is needed on edible medicinal mushrooms to overcome the research gap to use its clinical potential to prevent non-communicable diseases.

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Section: Role Of Vitamin D In Blood Glucose Regulationsmentioning

confidence: 99%

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Das

Chen

et al. 2022

Pharmaceutics

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“…Two reviewers exactly screened documents by title and abstract, and 2011 records were excluded from the process. Finally, from 168 full texts, 12 eligible trials [ 13 , 30 – 40 ] were selected for the systematic review and meta-analysis (Fig. 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…The studies were published between 2010 and 2020. Ten of included studies have been designed as RCT [ 31 – 40 ] and ones as non-RCT [ 30 ], and Verrusio et al [ 13 ] designed their study as a before-after experiment, so it was not analyzed in the meta-analysis. Six studies were conducted in the European countries [ 13 , 30 , 32 , 33 , 36 , 38 ], two in Lebanon [ 39 , 42 ], and four enrolled in other countries.…”

Section: Resultsmentioning

confidence: 99%

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Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials

Qorbani

Zarei

Moradi

et al. 2022

Diabetol Metab Syndr

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Background There has been a longstanding interest in the potential effect of vitamin D in preventing cardiac-metabolic diseases. However, there are divergent results regarding the impact of vitamin D supplementation (VDS) on managing cardiac-metabolic outcomes in the elderly population. Material and method We systematically searched electronic databases; Web of Science, PubMed, Scopus, EMBASE, Cochrane, and ProQuest. We included all trials that evaluated the effect of VDS on cardiac-metabolic risk factors in the elderly population, which were published until 30 September 2021. The effects of VDS on cardiac-metabolic outcomes were assessed using standardized mean difference (SMD). A random-effect model was used to pool the SMD and 95% confidence interval (CI). Result The literature search identified 4409 studies, of which 12 trials met inclusion criteria. Results of random effect meta-analysis indicated a significant reduction in total cholesterol (TC) (SMD: − 0.14 mg/dl; 95% CI: − 0.25, − 0.02) and triglyceride (TG) (SMD: − 0.45 mg/dl; 95% CI: − 0.86, − 0.04) with VDS compared to the placebo. The subgroup analyses revealed that the reduction of TG in patients with diabetes and vitamin D deficiency was significant. Furthermore, short-term intervention (≤ 6 months) induced a significantly lower level of TG and insulin in comparison to longer duration (> 6 months). Conclusion The study suggests that VDS could improve insulin concentration and dyslipidemia in the elderly population. The systematic review was registered in Alborz university of medical sciences with 2060-01-03-1397 number and the Ethics council IR.ABZUMS.REC.1397.207 number.

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“…It has also a role in glucose homeostasis and sensitivity to insulin. 9 In addition, recent work has shown that patients diagnosed with vitamin D deficiency (serum level of [25(OH)D] below 20 ng/ml) had a higher prevalence of DN than those who were diagnosed with insufficiency (20 -30 ng/ml) or sufficiency (30 to 60 ng/ml). 8,10,11 Moreover, many studies suggest the use of vitamin D supplementation could improve the symptoms of DN.…”

Section: Introductionmentioning

confidence: 99%

Is diabetic neuropathy associated with vitamin D status? A meta-analysis

et al. 2021

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Several studies have been conducted to investigate the relation between 25-hydroxyvitamin D [25(OH)D] level and diabetic neuropathy (DN). However, there is still no clear conclusion due to differences in study design and cut-off values used in the published work, in addition to the absence of a comprehensive meta-analysis on the topic. The present systematic review and meta-analysis therefore aims at clarifying the association between vitamin D level and peripheral DN in patients with type 2 diabetes mellitus. Primary research studies that explored the association between 25(OH)D level and diabetic peripheral neuropathy in type 2 diabetes were located from Medline, EMBASE, Web of Science, Cochrane Library, CINHAL, and Google Scholar. Twenty-six studies met the inclusion criteria with 6277 participants where 2218 were diabetic with DN, 2959 were diabetic without DN and 406 were healthy. Diabetic patients with DN showed significantly lower serum 25(OH)D compared to patients without DN (standardized mean difference (SMD) of −0.92 (95% CI = −1.18 to −0.65, I2 = 93.3%, p < 0.0001). The pooled OR value of vitamin D deficiency was higher in patients with DN, 1.84 (95% CI = 1.46 to 2.33, p < 0.0001) and 2.87 (95% CI = 1.10 to 7.52, p = 0.03) when using fixed-effects and random-effects models, respectively. Vitamin D deficiency has been found to be highly prevalent among diabetic patients with neuropathy. Since 25(OH)D has been implicated in glucose hemostasis and showed benefit in reducing neuropathy symptoms, its supplementation is warranted for this population of patients.

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Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

Cited by 32 publications

References 49 publications

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Medicinal Components in Edible Mushrooms on Diabetes Mellitus Treatment

Effect of vitamin D supplementation on cardiac-metabolic risk factors in elderly: a systematic review and meta-analysis of clinical trials

Is diabetic neuropathy associated with vitamin D status? A meta-analysis

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