Non-morphogenic effect of Sonic Hedgehog on gastric H+,K+-ATPase activity

Fujii, Takuto; Phutthatiraphap, Siriporn; Shimizu, Takahiro; Takeshima, Hiroshi; Sakai, Hideki

doi:10.1016/j.bbrc.2019.08.099

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“…The H + /K + -ATPase proton pump comprises α and β subunits [47]. Gastric H + /K + -ATPase plays a key role in regulating gastric acid secretion [48].…”

Section: Discussionmentioning

confidence: 99%

Acidified Pepsin Promotes Laryngeal Precancerosis by Upregulating H +/K +-ATPase and Activating Mitophagy in Laryngeal Epithelial Cells

Cheng

et al. 2020

SSRN Journal

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Background: Although laryngopharyngeal re ux (LPR) has been implicated in various upper aerodigestive tract and laryngeal diseases, the underlying mechanisms remain elusive. In this study, we investigated the role of gastric acidi ed pepsin in laryngeal precancerosis. Methods: The in vitro and in vivo effects of acidi ed pepsin on H + /K + -ATPase expression and autophagy/mitophagy induction in mouse laryngeal epithelial cells were assessed by hematoxylin and eosin staining, immunohistochemistry, CCK-8 assay, ow cytometry, Western blotting, and quantitative real-time PCR. Additionally, the levels of pepsin and H+/K+-ATPase α and β subunits in 31 human laryngeal mucosal specimens were assessed by immunohistochemical staining.

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“…The H + /K + -ATPase proton pump comprises α and β subunits [47]. Gastric H + /K + -ATPase plays a key role in regulating gastric acid secretion [48].…”

Section: Discussionmentioning

confidence: 99%