Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008

Fujii, Takuto; Sugimoto, Kenji; Noda, T; Shimizu, Takahiro; Matsuya, Yûji; Sakai, Hideki

doi:10.1016/j.bbrc.2021.06.056

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Both strong and weak acids can induce sour taste; however, the transmission mechanisms of the two acid messages in sour TRCs (sTRCs) are completely distinct. For fully ionized strong acids, the extracellular H + enters the cell through the Zn 2+ -sensitive H + channel at the tip of sTRCs (Fujii et al, 2023). Most weak organic acids penetrate into the bilayer phospholipids at the top of sTRCs in the form of undissociated neutral molecules.…”

Section: 25mentioning

confidence: 99%

Taste and its receptors in human physiology: A comprehensive look

Li,

Sun

et al. 2024

Food Frontiers

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Increasing evidence shows that food has significance beyond traditional perception (providing nutrition and energy) in maintaining normal life activities. It is indicated that the sense of taste plays a crucial part in regulating human life activities. Taste is one of the basic physiological sensations in mammals, and it is the fundamental guarantee for them to perceive, select, and ingest nutrients in order to survive. With the advances in electrophysiology, molecular biology, and structural biology, studies on the intracellular and extracellular transduction mechanisms of taste have made great progress and gradually revealed the indispensable role of taste receptors in the regulation and maintenance of normal physiological activities. Up to now, how food regulates life activities through the taste pathway remains unclear. Thus, this review comprehensively and systematically summarizes the current study about the sense of taste, the function of taste receptors, the taste–structure relationship of gustatory molecules, the cross‐talking between distinctive tastes, and the role of the gut–organ axis in the realization of taste. Moreover, we also provide forward‐looking perspectives on taste research to afford a scientific basis for revealing the scientific connotation of taste receptors regulating body health.

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Section: 25mentioning

confidence: 99%

Taste and its receptors in human physiology: A comprehensive look

Li,

Sun

et al. 2024

Food Frontiers

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“…The gastric proton pump (H + -K + -ATPase) is responsible for acid secretion in the parietal cells of the stomach, and the pump is an essential therapeutic target for acid-related diseases 28 . Potassiumcompetitive acid blockers (P-CABs), such as SCH28080 and vonoprazan (TAK-438), selectively inhibit gastric H + -K + -ATPase in a K + -competitive manner 29 .…”

Section: Impairment Of the Atp13a2 Activity By Pd-associated Mutationsmentioning

confidence: 99%

Parkinson’s disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase

et al. 2023

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Mutations in the human ATP13A2 (PARK9), a lysosomal ATPase, cause Kufor-Rakeb Syndrome, an early-onset form of Parkinson’s disease (PD). Here, we demonstrate that ATP13A2 functions as a lysosomal H+,K+-ATPase. The K+-dependent ATPase activity and the lysosomal K+-transport activity of ATP13A2 are inhibited by an inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase, thapsigargin, and K+-competitive inhibitors of gastric H+,K+-ATPase, such as vonoprazan and SCH28080. Interestingly, these H+,K+-ATPase inhibitors cause lysosomal alkalinization and α-synuclein accumulation, which are pathological hallmarks of PD. Furthermore, PD-associated mutants of ATP13A2 show abnormal expression and function. Our results suggest that the H+/K+-transporting function of ATP13A2 contributes to acidification and α-synuclein degradation in lysosomes.

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Nine geranylgeranylated derivatives isolated from the roots of Rhus chinensis Mill.

Lai

Wang

et al. 2023

Phytochemistry

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Inhibition of gastric H+,K+-ATPase by new dihydropyrazole derivative KYY-008

Cited by 3 publications

References 33 publications

Taste and its receptors in human physiology: A comprehensive look

Taste and its receptors in human physiology: A comprehensive look

Parkinson’s disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase

Nine geranylgeranylated derivatives isolated from the roots of Rhus chinensis Mill.

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