Non-Metastatic Basaloid Squamous Cell Carcinoma of the Uterine Cervix in a Woman with History of Subtotal Hysterectomy

Salarvand, Samaneh; Haeri, Hydeh; Ghalehtaki, Reza; Niknejad, Nakisa; Vaezi, Maryam

doi:10.5812/ijcm.9301

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…One of the rarest locations of that disease is the uterine cervix. 4 It is thought that the tumour has a more aggressive course than the classical cervical squamous cell carcinoma (SCC), higher metastatic potential, and poorer prognosis. 5 We present a case of a young woman with an asymptomatic course of BSCC, diagnosed on a prophylactic examination, which underwent radical surgical treatment performed thereafter.…”

Section: 3mentioning

confidence: 99%

Basaloid squamous cell carcinoma of uterine cervix in a young adult - A case report

Yordanov¹,

Slavchev²,

Nanev³

et al. 2019

amj

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Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare and aggressive malignancy. It has poorer clinical outcomes than squamous cell carcinoma of the uterine cervix. The tumour has specific microscopic features, and usually affects patients in their late 60s and 70s. We present a very rare case of a 30-year-old woman, who was diagnosed on a prophylactic examination and was treated with radical hysterectomy and pelvic lymph node dissection. The follow-up of the patient is ongoing.

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Section: 3mentioning

confidence: 99%

Basaloid squamous cell carcinoma of uterine cervix in a young adult - A case report

Yordanov¹,

Slavchev²,

Nanev³

et al. 2019

amj

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show abstract

“…Interestingly, one case showed a history of subtotal hysterectomy 26 years prior, similar to our case. 8 The incidence of cervical stump carcinoma is 2.2% of all cervical cancer cases regardless of the histological type, and the mean interval between the surgery and the cancer diagnosis was 17.6 years. 9 Our case had a 41-year interval after the partial hysterectomy.…”

Section: Discussionmentioning

confidence: 97%

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis

et al. 2021

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There is a lack of knowledge about molecular alterations in basaloid squamous cell carcinoma (BSCC) of the uterine cervix. A 72-year-old woman with a history of previous subtotal hysterectomy and current vaginal bleeding was referred to our hospital. Initially, adenoid cystic carcinoma (ACC) was diagnosed upon cervical cytology and biopsy. Chest imaging showed multiple metastatic lesions in both lungs. The surgical specimen showed BSCC with diffuse p16 immunoreactivity and negativity for S-100, c-kit, and neuroendocrine markers. There was a focal minor ACC component, which could have explained the previous cytology and biopsy diagnosis. Next-generation sequencing with two different panels showed coexisting PIK3CA mutation and NTRK2 fusion with 10 additional variants of unknown significance ( ATR, DAXX, FAM123B, JAK1, KEL, MLL2, NOTCH2, PALB2, POLD1, POLE). The MYB gene fusions were not identified. The patient received chemotherapy with TRK inhibitor larotrectinib and carboplatin, which caused shrinkage of metastatic lung nodules. This is the first report of cervical BSCC with extensive molecular workup, which detected multiple genetic events, including targetable ones, which are potentially implicated in the development of a tumor. The accumulation of data and further studies on this tumor are necessary to define its diagnostic criteria and its clinical and biological behavior.

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Uncommon Histopathological Subtypes and Variants of Cervical Carcinoma Diagnosed at a Tertiary Care Centre: A Case Series

N. S.,

Dhanabal,

Sundaram

et al. 2024

Cureus

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Introduction Cervical cancer ranks among the top gynaecological cancers worldwide. It is linked to lower socioeconomic status and high human papillomavirus (HPV) prevalence. This is a series of six cervical carcinoma cases analysed from 2021 to 2023 at our tertiary care centre to identify rare subtypes of cervical carcinoma. We document rare subtypes, which include glassy cell carcinoma, small cell neuroendocrine carcinoma, papillary squamous-transitional variant, basaloid squamous cell carcinoma and serous carcinoma of the uterine cervix. Immunohistochemistry (IHC) was helpful in confirmation of the subtypes and in diagnosing HPV-associated cases. Materials and methods This case series comprises six cases, including rare subtypes and variants of cervical carcinoma histopathologically diagnosed by the Department of Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India, between 2021 and 2023. The demographic profile and patient details were obtained from the hospital information system and archival case files after obtaining informed consent from the patients. The H&E and relevant IHC slides along with histopathology reports of the included cases were analysed and studied. Results This series includes six cases of rare subtypes of cervical carcinoma, comprising glassy cell carcinoma, small cell neuroendocrine carcinoma, papillary squamous-transitional variant, basaloid squamous cell carcinoma (SCC), and serous carcinoma. Each subtype displays distinct clinicopathological features, emphasizing the need for specific diagnostic and treatment approaches, which are crucial in improving patient survival. Conclusion Six rare subtypes and variants of cervical carcinoma have been discussed in this case series, after correlating with histopathology reports and clinical and radiological findings. Understanding the histopathological characteristics of these rarer subtypes is essential for accurate diagnosis and timely intervention. This series highlights the importance of comprehensive screening strategies, early diagnosis and awareness of rarer subtypes and variants of cervical carcinoma among healthcare professionals. These factors can tailor therapeutic options and improve patient outcomes.

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Non-Metastatic Basaloid Squamous Cell Carcinoma of the Uterine Cervix in a Woman with History of Subtotal Hysterectomy

Cited by 3 publications

References 13 publications

Basaloid squamous cell carcinoma of uterine cervix in a young adult - A case report

Basaloid squamous cell carcinoma of uterine cervix in a young adult - A case report

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis

Uncommon Histopathological Subtypes and Variants of Cervical Carcinoma Diagnosed at a Tertiary Care Centre: A Case Series

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