Basaloid squamous cell carcinoma of uterine cervix in a young adult - A case report

Abstract

Basaloid squamous cell carcinoma of the uterine cervix is an extremely rare and aggressive malignancy. It has poorer clinical outcomes than squamous cell carcinoma of the uterine cervix. The tumour has specific microscopic features, and usually affects patients in their late 60s and 70s. We present a very rare case of a 30-year-old woman, who was diagnosed on a prophylactic examination and was treated with radical hysterectomy and pelvic lymph node dissection. The follow-up of the patient is ongoing.

Basaloid Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case With Molecular Analysis

“…The clinical picture of BSCC is similar to classical SCC and a few reports in young adults 4,7 were reported. Interestingly, one case showed a history of subtotal hysterectomy 26 years prior, similar to our case.…”

“…An accurate diagnosis is important for prognosis and treatment. 4 Negative immunostaining with neuroendocrine markers in our case ruled out neuroendocrine carcinomas, leaving ACC as the main differential diagnosis.…”

“…3 Uterine cervical BSCC usually affects old women in their late 60s and 70s and is generally regarded as an aggressive malignancy. 4 Accumulated data on clinical behavior, morphology, diagnostic criteria, pathogenesis, and prognosis of cervical BSCC is lacking and this can lead to misinterpretation. Moreover, pure BSCC is rare, 5,6 making preoperative diagnosis on small-sized samples even more challenging.…”

“…High-risk human papilloma viruses (HPV), HPV16, and HPV18 are commonly associated with BSCC; in addition, smoking and alcohol consumption are regarded as predisposing factors. 4…”

“…5 Some useful immunohistochemical (IHC) markers for differential diagnosis are pancytokeratin AE1/AE3, CK7, CD117/c-kit, carcinogenic embryogenic antigen, cancer antigen 19-9, EMA, 34BE12, p63, chromogranin, synaptophysin, platelet-derived growth factor receptor, ER, and CD56. 4 However, IHC cannot alone be the base for diagnosis, because of very few reported cases with conflicting IHC results.…”