Based on the nonlocal strain gradient theory, the coupling nonlinear dynamic equations of a rotating double‐tapered cantilever Timoshenko nano‐beam are derived using the Hamilton principle. The equation of motion is discretized via the differential quadrature method. The effects of the angular velocity, nonlocal parameter, slenderness ratio, cross‐section parameter, and taper ratios are examined and discussed. It is shown that taper ratios and cross‐section parameter play a significant role in the vibration response of a rotating cantilever nano‐beam. Further as rotational angular velocity increases, the taper ratios and cross‐section parameter effect on the frequency response are increased for first modes of vibration.