Non-isothermal thermogravimetry as an accelerated tool for the shelf-life prediction of paracetamol formulations

Calvino, Martina Maria; Lisuzzo, Lorenzo; Cavallaro, Giuseppe; Milioto, Stefana

doi:10.1016/j.tca.2021.178940

Cited by 17 publications

(10 citation statements)

References 66 publications

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“…HFNS at a 0.4% loading may have contributed to agglomeration and weakening of the intermolecular forces with polyurea chains. To give more insight into the thermal stability of the composites, the kinetics parameters such as the activation energy for the degradation process is a more robust parameter [90,91]. Therefore, MTGA results were analyzed through real-time deconvolution techniques (discrete Fourier transformation) to obtain the activation energy values (E a ) as functions of the extent of conversion without an assumption on the degradation model [92].…”

Section: Viscoelastic Properties Polyurea Nanocomposites Membranesmentioning

confidence: 99%

Nonporous, Strong, Stretchable, and Transparent Electrospun Aromatic Polyurea Nanocomposites as Potential Anticorrosion Coating Films

et al. 2021

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This study, for the first time, focused on the fabrication of nonporous polyurea thin films (~200 microns) using the electrospinning method as a novel approach for coating applications. Multi-walled carbon nanotubes (MWCNTs) and hydrophilic-fumed nanosilica (HFNS) were added separately into electrospun polyurea films as nano-reinforcing fillers for the enhancement of properties. Neat polyurea films demonstrated a tensile strength of 14 MPa with an elongation of 360%. At a loading of 0.2% of MWCNTs, the highest tensile strength of 21 MPa and elongation of 402% were obtained, while the water contact angle remained almost unchanged (89°). Surface morphology analysis indicated that the production of polyurea fibers during electrospinning bonded together upon curing, leading to a nonporous film. Neat polyurea exhibited high thermal resistance with a degradation temperature of 380 °C. Upon reinforcement with 0.2% of MWCNTs and 0.4% of HFNS, it increased by ~7 °C. The storage modulus increased by 42 MPa with the addition of 0.2% of MWCNTs, implying a superior viscoelasticity of polyurea nanocomposite films. The results were benchmarked with anti-corrosive polymer coatings from the literature, revealing that the production of nonporous polyurea coatings with robust strength, elasticity, and thermal properties was achieved. Electrospun polyurea coatings are promising candidates as flexible anti-corrosive coatings for heat exchanges and electrical wires.

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Section: Viscoelastic Properties Polyurea Nanocomposites Membranesmentioning

confidence: 99%

Nonporous, Strong, Stretchable, and Transparent Electrospun Aromatic Polyurea Nanocomposites as Potential Anticorrosion Coating Films

et al. 2021

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“…Such an approach in The stability parameter denoted as the "shelf-life" was calculated using the data that best fitted the decomposition mechanism of AMB and FT tablets. Such an approach in non-isothermal thermogravimetric data for shelf-life prediction of drugs was recently used by Calvino et al [12]. Shelf-life data are presented in Table 4.…”

Section: Kinetics Of the Ambroxol Hydrochloride Pure And In The Mixturementioning

confidence: 99%

“…Thermo-analytical (TA) tech-niques have been used to rapidly evaluate the purity, degradation kinetics, and physical property of drugs [5][6][7][8][9][10][11]. A typical application is the use of non-isothermal thermogravimetric (TG) runs for estimating the thermal stability and shelf-life of a material (drug) at a specific temperature [12,13]. Moreover, these techniques alerted compatibility problems and indicated the most favorable directions for a successful formulation [14,15].…”

Section: Introductionmentioning

confidence: 99%

Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions

et al. 2021

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Ambroxol hydrochloride (AMB), used as a broncho secretolytic and an expectorant drug, is a semi-synthetic derivative of vasicine obtained from the Indian shrub Adhatoda vasica. It is a metabolic product of bromhexine. The paper provides comprehensive and detailed research on ambroxol hydrochloride, gives information on thermal stability, the mechanism of AMB degradation, and data of practical interest for optimization of formulation that contains AMB as an active compound. Investigation on pure AMB and in commercial formulation Flavamed® tablet (FT), which contains AMB as an active compound, was performed systematically using thermal and spectroscopic methods, along with a sophisticated and practical statistical approach. AMB proved to be a heat-stable and humidity-sensitive drug. For its successful formulation, special attention should be addressed to excipients since it was found that polyvinyl pyrrolidone and Mg stearate affect the thermal stability of AMB. At the same time, lactose monohydrate contributes to faster degradation of AMB and change in decomposition mechanism. It was found that the n-th order kinetic model mechanistically best describes the decomposition process of pure AMB and in Flavamed® tablets.

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“…In addition, in recent years the thermal behavior study and the assessment of thermal stability have become crucial issues in the characterization of different classes of materials and nanocomposites via the use of thermal analysis techniques. As a matter of fact, in the last one or two decades these aspects were particularly developed for glasses [19][20][21], organic-inorganic hybrids [22][23][24][25][26], ceramic and geopolymer materials [27,28], nanocomposites [29,30], polysiloxanes [31], analgesics and antibiotics [32] and coordination compounds [33][34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Thermal behavior and antibacterial studies of a carbonate Mg–Al-based layered double hydroxide (LDH) for in vivo uses

Cardinale

Ciprioti

Fortunato

et al. 2022

J Therm Anal Calorim

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The goal of this work is to study the thermal behavior and the antibacterial properties of a MgAl-CO3 layered double hydroxide (LDH), which demonstrated high efficiency in removing chromium (VI) from contaminated industrial wastewater. The compound has been synthesized via co-precipitation route (direct method) followed by hydrothermal treatment, obtaining nanoscopic crystallites with a partially disordered (turbostratic) structure. After its synthesis, the compound was characterized by means of X-ray powder diffraction, field emission scanning electron microscope, inductively coupled plasma atomic emission spectroscopy and analysis and Fourier transform infrared spectroscopy. On the other hand, with the view to check the drug delivery and surgical tools usage of MgAl-CO3, antibacterial tests, performed according to the Kirby–Bauer method, revealed the inability the growth of the pathogenic bacterial strains. Thermogravimetry and differential thermal analysis revealed that evolution of water from the material occurs in two stages upon heating and a noticeable interaction takes place between water (in the vapor phase) and MgAl-CO3. Kinetic analysis of both steps provides almost constant values of activation energy, with the following average values in the range 0.1 < a < 0.9: E1 = (66 ± 9) kJ mol‒1; E2 = (106 ± 7) kJ mol‒1. Finally, prediction of reasonable reaction times extrapolated at 25 and 37 °C has been made from kinetic parameters of the first step, while almost unrealistic reaction time values were determined using the same procedure with kinetic parameters related to the second step.

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Non-isothermal thermogravimetry as an accelerated tool for the shelf-life prediction of paracetamol formulations

Cited by 17 publications

References 66 publications

Nonporous, Strong, Stretchable, and Transparent Electrospun Aromatic Polyurea Nanocomposites as Potential Anticorrosion Coating Films

Nonporous, Strong, Stretchable, and Transparent Electrospun Aromatic Polyurea Nanocomposites as Potential Anticorrosion Coating Films

Thermo-Analytical and Compatibility Study with Mechanistic Explanation of Degradation Kinetics of Ambroxol Hydrochloride Tablets under Non-Isothermal Conditions

Thermal behavior and antibacterial studies of a carbonate Mg–Al-based layered double hydroxide (LDH) for in vivo uses

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