Non-ionic small amphiphile based nanostructures for biomedical applications

Abstract

Amphiphiles in action: self-assembled nanostructures for drug delivery and imaging.

Supramolecular self-associating amphiphiles: determination of molecular self-association properties and calculation of critical micelle concentration using a high-throughput, optical density based methodology

“…1,2 The resultant self-associated structures formed are stabilised through an assortment of intermolecular non-covalent interactions such as: hydrogen bonding; ion-ion interactions; van der Waals forces; π-π stacking; and hydrophobic/hydrophilic interactions. [3][4][5] The importance of this class of compounds cannot be underestimated, with examples utilised as antimicrobial agents, [6][7][8] anticancer agents, [9][10][11] drug delivery vehicles, [12][13][14] and within the oil related industries. 15,16 Amphiphiles, in aqueous solutions, have two simultaneous tendencies: to aggregate within the solvent bulk to form structures such as micelles, or to adsorb at the interface, 17 a process which affects surface tension.…”

Self-assembly of carbohydrate-based small amphiphiles and their applications in pathogen inhibition and drug delivery: a review

“…[1][2][3][4][5] Besides polymeric amphiphiles, non-polymeric small amphiphiles too have gained considerable attention owing to precise control over their molecular weight, polydispersity, and hydrophobic-lipophilic balance (HLB). [6][7][8][9] Moreover, these aggregate into well-defined constructions, instead of a mixture of various compositions. 9 Self-assembly of amphiphiles produces different structures ranging from micelles, helices, fibers to tubes and vesicles.…”

“…[6][7][8][9] Moreover, these aggregate into well-defined constructions, instead of a mixture of various compositions. 9 Self-assembly of amphiphiles produces different structures ranging from micelles, helices, fibers to tubes and vesicles. [9][10][11][12][13] The study of amphiphilic self-assembled nanostructures is of importance because of their relevance in the field of biomedical research that includes applications as solubility enhancers, surface coating agents, imaging agents, and drug/biomolecules delivery vehicles, etc.…”

“…9 Self-assembly of amphiphiles produces different structures ranging from micelles, helices, fibers to tubes and vesicles. [9][10][11][12][13] The study of amphiphilic self-assembled nanostructures is of importance because of their relevance in the field of biomedical research that includes applications as solubility enhancers, surface coating agents, imaging agents, and drug/biomolecules delivery vehicles, etc. 14 The demand for the generation of specific nanostructures with precise control over the size and morphology is increasing due to their pivotal role for the regulation of various biomedical applications such as pathogen inhibition.…”

Amphiphilic N-Oligoethyleneglycol-imidazolium Derivatives of p-tert-Butylthiacalix[4]arene: Synthesis, Aggregation and Interaction with DNA

“…[7][8][9][10] The introduction of ethylene glycol fragments into amphiphilic molecules leads to an increase in their water solubility and improves biocompatibility. [11] The calixarene platform allows to combine various functional groups on one platform. Moreover, easy synthesis and functionalization of calixarenes, as well as their low toxicity, make them promising molecular platforms for creating non-viral vectors for gene delivery as well as drug delivery agents.…”