Non-invasively detected carotid stenosis and ischaemic heart disease in men with leg arteriosclerosis

Ögren, Magnus; Hedblad, Bo; So, Isacsson; Janzon, Lars; Jungqvist, Gudrun; Lindell, S.‐E.

doi:10.1016/0140-6736(93)92123-b

Cited by 112 publications

(65 citation statements)

References 19 publications

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“…This test has been shown to have a good correlation with the risk of cardiovascular disease. [9][10][11][12][13][14][15][16][17][18] Another measurement is the pulse wave velocity (PWV), which is a calculation based on the pulse transit time and the distance traveled by the pulse between two recording sites. This has been shown to be a marker for arterial wall stiffness.…”

Section: Introductionmentioning

confidence: 99%

A study of arteriosclerosis in healthy subjects with HBV and HCV infection

et al. 2005

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Section: Introductionmentioning

confidence: 99%

A study of arteriosclerosis in healthy subjects with HBV and HCV infection

et al. 2005

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“…Epidemiological research has focused mainly on diabetes-related coronary and carotid artery disease, because of its high morbidity and mortality rates. Although PAD does not rank among the main primary causes of mortality, it causes serious discomfort and disability, and has been shown to be associated with an increased all-cause and coronary heart disease mortality [3][4][5][6][7].…”

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confidence: 99%

Peripheral arterial disease in relation to glycaemic level in an elderly Caucasian population: the Hoorn Study

et al. 1995

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We investigated the cross-sectional association between peripheral arterial disease and glycaemic level in an age, sex, and glucose tolerance stratified random sample from a 50-74-year-old Caucasian population. Subjects treated with oral hypoglycaemic agents or insulin were classified as having known diabetes mellitus (KDM) (n = 67). Using two oral glucose tolerance tests, and based on World Health Organisation criteria, all other participants were categorized as having a normal (NGT) (n = 288), an impaired (IGT) (n = 170), or a diabetic (NDM) (n = 106) glucose tolerance. Prevalence rates of ankle-brachial pressure index less than 0.90 were 7.0%, 9.5%, 15.1% and 20.9% in NGT, IGT, NDM and KDM subjects, respectively (chi-square test for linear trend: p < 0.01). Prevalence rates of any peripheral arterial disease (ankle-brachial pressure index < 0.90, at least one monophasic or absent Doppler flow curve or vascular surgery) were 18.1%, 22.4%, 29.2% and 41.8% in these categories (chi-square test for linear trend: p < 0.0001). The prevalence of any peripheral arterial disease was higher in KDM and NDM than in NGT (p < 0.03, p < 0.0001, respectively), whereas no statistically significant difference was demonstrated between IGT and NGT. The same applied when using the ankle-brachial pressure index criterion. Logistic regression analyses showed that any arterial disease was significantly associated with HbA1c, fasting and 2-h post-load plasma glucose after correction for cardiovascular risk factors (odds ratios and 95% confidence intervals 1.35; 1.10-1.65 per %, 1.20; 1.06-1.36 and 1.06; 1.01-1.12 per mmol/l, respectively), whereas it was not associated with fasting and 2-h post-load specific insulin. Ankle-brachial pressure indices were not associated with either plasma glucose parameters or insulin in univariate or multivariate analyses. In conclusion, parameters of glucose tolerance are independently associated with any peripheral arterial disease, whereas insulin is not.

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“…Among the 203 patients studied there was a history of TIA in 18.8%, stroke in 30.2%, and heart attack in 34.3% (Table 1). Therefore, the population did not lack clinical events, but the severity of disease did not appear to correlate significantly with such events even though it has been shown to correlate in population studies 13,14 and a clinical study. 1 Another potential bias with this study, which may account for the correlation results, is that non-invasive techniques were used to assess for stenosis as a means of determining disease severity.…”

Section: Discussionmentioning

confidence: 99%

“…These include cross-sectional CVD morbidity studies of symptomatic patients 1,2 ; cross-sectional CVD studies of both symptomatic and asymptomatic patients, with PAD as the reference group [3][4][5][6][7][8][9] and with COD as the reference group 6,[10][11][12] ; and CVD prospective morbidity studies with PAD as the reference group, [13][14][15] and with COD as the reference group. 16,17 CVD prospective mortality has also been evaluated with PAD as the refer-ence group, 13,[18][19][20][21] and with COD as the reference group. 17,[22][23][24] These studies in general show a strong correlation between the presence of atherosclerosis in a given arterial bed and the co-prevalence or subsequent development of atherosclerosis in another arterial bed.…”

Section: Introductionmentioning

confidence: 99%

The correlation between the severity of peripheral arterial disease and carotid occlusive disease

et al. 1999

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Peripheral arterial disease (PAD) and carotid occlusive disease (COD) are both known to be specific manifestations of atherosclerosis. Because they both have a common cause, it is reasonable to hypothesize that they should correlate with each other to a certain extent, and previous studies have shown that there is a correlation between the prevalence of PAD and COD. The purpose of this study was to determine whether a correlation exists between the severity of PAD and the severity of COD by retrospectively looking at a group of 203 patients who underwent non-invasive testing for suspicion of PAD at the San Diego VA Hospital or UCSD Medical Center, and who also had a non-invasive duplex carotid scan. The severity of PAD was assessed by segmental blood pressure ratios (leg segment/arm ratio) in each leg taken at the toe, ankle, and below the knee, as well as the peak flow velocity of the posterior tibial artery. The severity of COD was assessed by duplex ultrasound scans of six distinct segments of the carotid artery system: the right and left common, internal, and external carotid arteries. Correlation analysis showed r = 0.23 (p = 0.001) when comparing a PAD aggregate standard score with the number of diseased carotid arteries (Ͼ50% stenosis), and r = 0.23 (p = 0.001) when comparing a PAD aggregate standard score with an average COD score. Because about 50% of the patients had undergone surgical intervention on their leg or carotid arteries, another correlation analysis restricted to patients with no surgical interventions (n = 97) was performed. The above correlations were slightly attenuated in this analysis, r = 0.21 (p = 0.043) and r = 0.17 (p = 0.092), respectively. The results indicate that there is a modest but significant correlation between the severity of PAD and the severity of COD in a population with a high prevalence of both.

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Non-invasively detected carotid stenosis and ischaemic heart disease in men with leg arteriosclerosis

Cited by 112 publications

References 19 publications

A study of arteriosclerosis in healthy subjects with HBV and HCV infection

A study of arteriosclerosis in healthy subjects with HBV and HCV infection

Peripheral arterial disease in relation to glycaemic level in an elderly Caucasian population: the Hoorn Study

The correlation between the severity of peripheral arterial disease and carotid occlusive disease

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