A study of arteriosclerosis in healthy subjects with HBV and HCV infection

Moritani, Makoto; Adachi, Kyoichi; Arima, Noriyuki; Takashima, Toshiharu; Miyaoka, Youichi; Niigaki, Misa; Furuta, K.; Sato, Shuichi; Kinoshita, Yoshikazu

doi:10.1007/s00535-005-1655-3

Cited by 27 publications

(37 citation statements)

References 32 publications

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“…22 In Japanese subjects, infection with HBV or HCV did not influence the severity of arteriosclerosis. 23 Moreover, chronic HBV and HCV infections were not associated with the presence or severity of coronary artery disease. 24 On the other hand, Ishizaka et al 25 reported that HCV seropositivity was independently associated with carotid arterial plaque and carotid intima-media thickening in 4784 individuals who underwent a general health screening test.…”

Section: Discussionmentioning

confidence: 97%

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Matsumae¹,

Abe

Nishimura³

et al. 2010

Hypertens Res

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Increased aortic stiffness is an independent predictor of death from cardiovascular disease in patients with end-stage renal disease (ESRD). Various factors that contribute to carotid-femoral pulse wave velocity (cfPWV) as a surrogate of aortic stiffness have been identified, but determinants of long-term worsening of aortic stiffness remain to be elucidated. To clarify the factors that accelerate aortic stiffness in hemodialysis patients, 148 patients with ESRD on hemodialysis were evaluated. At baseline, cfPWV and ankle-brachial blood pressure index (ABPI) were measured and clinical status including biochemical parameters, with or without hepatitis c virus (HCV) infection, diabetes mellitus (DM), cardiovascular disease, cerebrovascular disease and peripheral arterial disease at baseline, were evaluated. The cfPWV was measured again after a 3-year follow up and the annual change in cfPWV was calculated. The cfPWV decreased in 54 patients, worsened slowly in 47 (annual change in cfPWV ranged from 0 to 0.33 m s À1 per year), and worsened rapidly in 47 patients (annual change in cfPWV was more than 0.33 m s À1 per year). The prevalences of DM, HCV infection and peripheral arterial disease were the highest in the rapid progression group. Univariate analysis showed that age, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), LDL-C/HDL-C ratio, HCV infection, ABPI and number of vasculopathies were significantly associated with annual change in cfPWV. Stepwise regression analysis identified ABPI, LDL-C/HDL-C ratio and HCV infection as independent determinants of worsening of cfPWV. Further studies are needed to investigate the mechanism of HCV-related enhancement of aortic stiffness in ESRD patients.

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Section: Discussionmentioning

confidence: 97%

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Matsumae¹,

Abe

Nishimura³

et al. 2010

Hypertens Res

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“…[14] In a healthy population, Moritani et al also showed that presence of HBV and HCV infection had not affected the severity of arteriosclerosis. [15] In our study, age-, sex-, and dialysis duration-matched non-diabetic HCV(+) and HCV(−) HD patients were compared. There was no difference between groups with respect to smoking habits, hypertension, left ventricular hypertrophy, and family history of diabetes or hypertension.…”

Section: Discussionmentioning

confidence: 99%

Determination of the Impact of Hepatitis C Virus on Insulin Resistance and Arterial Stiffness in Hemodialysis Patients

et al. 2008

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“…The authors then read the full text of all 29 articles, and excluded studies that were not suitable for this meta-analysis. Eleven articles were excluded because they were the incorrect type of articles, such as reviews and workshop summaries; five articles had the wrong methodology (three included patients who had concurrent infection with other pathogens); one article was a cross-sectional study and did not study the relationship between exposure to HBV and atherosclerosis [15]; one article that considered cerebrovascular disease as an outcome included both ischaemic and haemorrhagic cerebrovascular disease [7]; seven articles had the wrong outcomes (they studied the parameters related to atherosclerosis but did not set a threshold to define atherosclerosis) [4][5][6][16][17][18][19]; and one article was a cohort study, but there was no other cohort study to perform the meta-analysis [11]. Finally, we included five eligible studies for the meta-analysis [8-10, 12, 13].…”

Section: Study Identification and Selectionmentioning

confidence: 99%

The relationship between exposure to hepatitis B virus and increased atherosclerosis-associated morbidity — a meta-analysis

Liao

Que

et al. 2018

Kardiol Pol

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*Chen-guang Li and Song-jie Liao contributed equally to this study. A b s t r a c t Background and aim:The relationship between exposure to hepatitis B virus (HBV) and atherosclerosis-associated disease morbidity has not been clearly elucidated. We performed a meta-analysis to explore whether exposure to HBV is a risk factor for atherosclerosis-associated diseases. Methods:We searched the PubMed, Web of Science, Cochrane Library, Embase, and Scopus databases for related studies. We then chose the eligible studies for meta-analysis and assessed quality assessment and risk of bias. Results:The meta-analysis of the included studies showed that exposure to HBV tends to increase atherosclerosis-associated disease morbidity, but this increase was not statistically significant. Conclusions:Hepatitis B virus may not be a risk factor for atherosclerosis-associated diseases, but further studies that employ more sensitive clinical parameters are needed to verify this result.

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A study of arteriosclerosis in healthy subjects with HBV and HCV infection

Abstract: Infection with HBV or HCV does not influence the severity of arteriosclerosis in healthy subjects.

Cited by 27 publications

References 32 publications

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

What factors accelerate aortic stiffening in hemodialysis patients? An observational study

Determination of the Impact of Hepatitis C Virus on Insulin Resistance and Arterial Stiffness in Hemodialysis Patients

The relationship between exposure to hepatitis B virus and increased atherosclerosis-associated morbidity — a meta-analysis

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