Non-invasive quantification of age-related changes in the vertebral endplate in rats using in vivo DCE-MRI

Li, Hui; Yan, Jia-Zhi; Chen, Yongjie; Huang, Jiaxi

doi:10.1186/s13018-017-0669-x

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…[14] proposed a Gabor wavelet-based intervertebral disc localization algorithm, which used the gray ratio of the two and the height information of the intervertebral disc to achieve the classification of intervertebral disc degenerative changes. [15] found that MRI T2 mapping imaging technology could not only quantitatively assess the degree of lumbar intervertebral disc degeneration but also reflect the differences in the degenerative degrees of intervertebral discs in different levels through the T2 values of the nucleus pulposus, providing imaging basis for disease diagnosis. Through the clinical research, [16] found that CT and MRI had certain advantages in the clinical diagnosis of lumbar disc herniation, and the combined application of CT and MRI could reduce the rate of missed diagnosis if necessary.…”

Section: Literature Reviewmentioning

confidence: 99%

The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes

Yang

Liang

et al. 2020

PLoS ONE

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ObjectiveBased on the theoretical basis of Gabor wavelet transformation, the application effects of feature extraction algorithm in Magnetic Resonance Imaging (MRI) and the role of feature extraction algorithm in the diagnosis of lumbar vertebra degenerative diseases were explored. Q, et al. (2020) The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes. PLoS ONE 15(2): e0227894. https://doi.org/10. ConclusionThe feature extraction algorithm based on Gabor wavelet transformation could easily and quickly realize the localization of the lumbar intervertebral disc, and the accuracy of the results was ensured. In addition, from the aspect of vertebral body tracking, the tracking effects based on the KLT algorithm were better and faster than those based on the maximum mutual information method.

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Section: Literature Reviewmentioning

confidence: 99%

The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes

Yang

Liang

et al. 2020

PLoS ONE

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“…Our data clearly show an age-dependent loss of IVD fluidity, as seen in the inverse correlation of STIR intensity of both AAF and NP in discs of different age. This is a known result of a concurrent loss of collagen/proteoglycans and water content predominantly in the NP [ 21 , 22 ]. Additional linear regression analysis revealed a significant reduction of density in the AAF per year of age, which was close to 1 HU per year in the cMap.…”

Section: Discussionmentioning

confidence: 99%

Age-dependent microstructural changes of the intervertebral disc: a validation of proteoglycan-sensitive spectral CT

et al. 2021

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Objective To analyze the two major components of the intervertebral disc (IVD) in an ex vivo phantom, as well as age-related changes in patients. Methods Collagen and chondroitin sulfate were imaged at different concentrations in agar solution. Age-related changes in disc density were retrospectively analyzed in normal-appearing discs in dual-energy computed tomography (DECT) images from a patient cohort with various spinal pathologies (n = 136). All computed tomography (CT) scans were acquired using single-source DECT at 80 and 135 kVp with automatic exposure calculation. In 136 patients, the attenuation of normal-appearing discs on collagen/chondroitin maps (cMaps) correlated with the patients’ age with Pearson’s r using standardized regions of interest in the anterior anulus fibrosus (AAF) and nucleus pulposus (NP). Results DECT collagen mapping revealed concentration-dependent Hounsfield units (HU) of IVD components. For collagen, we found Pearson’s r = 0.9610 (95% CI 0.6789–0.9959), p = 0.0023 at 120 kVe, and r = 0.8824 (95% CI 0.2495–0.9871), p = 0.0199 in cMap. For chondroitin sulfate, Pearson’s r was 0.9583 (95% CI 0.6603–0.9956), p = 0.0026 at 120 kVp, and r = 0.9646 (95% CI 0.7044–0.9963), p = 0.0019 in cMap. Analysis of normal-appearing IVDs revealed an inverse correlation of density with age in the AAF: Pearson’s r = − 0.2294 at 135 kVp (95% CI − 0.4012 to − 0.04203; p=0.0141) and r = − 0.09341 in cMap (95% CI − 0.2777 to 0.09754; p = 0.0003). In the NP, age and density did not correlate significantly at 135 kVp (p = 0.9228) and in cMap (p = 0.3229). Conclusions DECT-based collagen mapping allows microstructural analysis of the two main intervertebral disc components—collagen and chondroitin sulfate. IVD density declines with age, presumably due to a reduction in collagen and chondroitin sulfate content. Age-related alterations of disc microstructure appear most pronounced in the AAF. Key Points • DECT-based collagen mapping allows precise analysis of the two main intervertebral disc components—collagen and chondroitin sulfate. • Intervertebral disc (IVD) density declines with age, presumably due to a reduction in collagen and chondroitin sulfate content. • Age-related alterations of disc microstructure are most pronounced in the anterior anulus fibrosus (AAF).

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“…26,27 Likewise, it was also recognized as the gold standard imaging modality to evaluate the link between endplate degeneration and disc issues. 28 Several MRI techniques have been developed to study in detail the endplate structures involved in IDD and LBP. 29,30 MRI scanners with various magnetic strengths ranging from 0.25 to 9.4 Tesla have been used (Table 1), with 1.5 and 3 Tesla MRI scanners being the most common.…”

Section: Diagnostic Role Of Mri In Low Back Painmentioning

confidence: 99%

Diagnostic Role of Magnetic Resonance Imaging in Low Back Pain Caused by Vertebral Endplate Degeneration

Din

Cheng

Yang

2021

Magnetic Resonance Imaging

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Low back pain (LBP) is a common health issue worldwide with a huge economic burden on healthcare systems. In the United States alone, the cost is estimated to be $100 billion each year. Intervertebral disc degeneration is considered one of the primary causes of LBP. Moreover, the critical role of the vertebral endplates in disc degeneration and LBP is becoming apparent. Endplate abnormalities are closely correlated with disc degeneration and pain in the lumbar spine. Imaging modalities such as plain film radiography, computed tomography, and fluoroscopy are helpful but not very effective in detecting the causes behind LBP. Magnetic resonance imaging (MRI) can be used to acquire high-quality threedimensional images of the lumbar spine without using ionizing radiation. Therefore, it is increasingly being used to diagnose spinal disorders. However, according to the American College of Radiology, current referral and justification guidelines for MRI are not sufficiently clear to guide clinical practice. This review aimed to evaluate the role of MRI in diagnosing LBP by considering the correlative contributions of vertebral endplates. The findings of the review indicate that MRI allows for fine evaluations of endplate morphology, endplate defects, diffusion and perfusion properties of the endplate, and Modic changes. Changes in these characteristics of the endplate were found to be closely correlated with disc degeneration and LBP. The collective evidence from the literature suggests that MRI may be the imaging modality of choice for patients suffering from LBP.

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Non-invasive quantification of age-related changes in the vertebral endplate in rats using in vivo DCE-MRI

Cited by 12 publications

References 16 publications

The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes

The application of key feature extraction algorithm based on Gabor wavelet transformation in the diagnosis of lumbar intervertebral disc degenerative changes

Age-dependent microstructural changes of the intervertebral disc: a validation of proteoglycan-sensitive spectral CT

Diagnostic Role of Magnetic Resonance Imaging in Low Back Pain Caused by Vertebral Endplate Degeneration

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