Non-invasive myocardial iron assessment in thalassaemic patients: T2 relaxometry and magnetization transfer ratio measurements

Papanikolaou, Nikolaos; Ghiatas, Abraham A.; Kattamis, Antonis; Ladis, C.; Kritikos, Nikolaos; Kattamis, Christos

doi:10.1080/028418500127345442

Cited by 29 publications

(14 citation statements)

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“…Iron has been shown to affect the magnetization transfer effect in the brain (Smith et al, 2009), and has been exploited in MTR imaging of rectal cancer to detect fibrosis (Martens et al, 2014;Papanikolaou et al, 2000). It has been suggested that iron is an important indicator of different physiological and pathological processes in MS (Bagnato et al, 2013), and we therefore investigated whether iron could have influenced out MTR changes.…”

Section: Discussionmentioning

confidence: 99%

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Fjær

Liu

Myhr

et al. 2015

Neurochemistry International

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Magnetization transfer ratio (MTR) is a magnetic resonance imaging (MRI) method which may detect demyelination not detected by conventional MRI in the central nervous system of patients with multiple sclerosis (MS). A decrease in MTR value has previously been shown to correlate to myelin loss in the mouse cuprizone model for demyelination. In this study, we investigated the sensitivity of MTR for demyelination in the myelin oligodendrocyte (MOG) 1-125 induced experimental autoimmune encephalomyelitis (EAE) mouse model. A total of 24 female c57Bl/6 mice were randomized to a control group (N = 6) or EAE (N = 18). MTR images were obtained at a preclinical 7 Tesla Bruker MR-scanner before EAE induction (baseline), 17-19 days (midpoint) and 31-32 days (endpoint) after EAE induction. Mean MTR values were calculated in five regions of the brain and compared to weight, EAE severity score and myelin content assessed by immunostaining for proteolipid protein and luxol fast blue, lymphocyte and monocyte infiltration and iron deposition. Contrary to what was expected, MTR values in the EAE mice were higher than in the control mice at the midpoint and endpoint. No significant difference in myelin content was found according to histo- or immunohistochemistry. Changes in MTR values did not correlate to myelin content, iron content, lymphocyte or monocyte infiltration, weight or EAE severity scores. This suggest that MTR measures of brain tissue can give significant differences between control mice and EAE mice not caused by demyelination, inflammation or iron deposition, and may not be useful surrogate markers for demyelination in the MOG1-125 mouse model.

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Section: Discussionmentioning

confidence: 99%

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Fjær

Liu

Myhr

et al. 2015

Neurochemistry International

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“…For example, in acute MI, myocardial capillary damage leads to hemorrhage which may be enhanced by coronary reperfusion (1-3). However, in vivo MRI studies have been limited due to artifacts from cardiorespiratory motion and blood flow (5). While advances in MRI now enable detection of hemorrhage in the human heart (6), current dark blood T 2 -weighted MRI techniques are limited by surface coil intensity problems and spin echo artifact (7), which may reduce diagnostic accuracy clinically (7, 8).…”

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confidence: 99%

Bright-Blood T ₂ -Weighted MRI Has High Diagnostic Accuracy for Myocardial Hemorrhage in Myocardial Infarction

Payne

Berry

Kellman

et al. 2011

Circ: Cardiovascular Imaging

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Background Myocardial hemorrhage after myocardial infarction (MI) usually goes undetected. We investigated the diagnostic accuracy of bright blood T2-weighted cardiac magnetic resonance imaging (MRI) for myocardial hemorrhage in experimental MI. Methods and Results MI was created in swine by occluding the left anterior descending (n=10) or circumflex (n=5) coronary arteries for 90 minutes followed by reperfusion for ≤3 days (n=2), 10 days (n=7) or 60 days (n=6). MRI was performed at 1.5 Tesla using bright blood T2-prepared steady-state free-precession, T2* and early (1 min) and late (10 – 15 min) gadolinium enhancement (EGE, LGE, respectively) MRI. Left ventricular sections and histology were assessed for hemorrhage by an experienced cardiac pathologist blinded to the MRI data. Hypointense regions on T2-weighted and contrast-enhanced MRI were independently determined by 3 cardiologists experienced in MRI who were also blinded to the pathology results. Eighty ventricular pathologic sections were matched with MRI (n=68 for EGE MRI). All sections with evidence of MI (n=63 (79%)) also exhibited hyperintense zones consistent with edema on T2-weighted MRI and infarct on LGE MRI. Myocardial hemorrhage occurred in 49 left ventricular sections (61%) and corresponded with signal voids on 48 T2-weighted (98%) and 26 LGE-MRI (53%). Alternatively, signal voids occurred in the absence of hemorrhage in 3 T2-weighted (90% specificity) and 5 LGE MRI (84% specificity). On EGE MRI, 27/43 cases of early MVO corresponded with hemorrhage (63% sensitivity) while 5/25 defects occurred in the absence of hemorrhage (80% specificity). The positive and negative predictive values for pathological evidence of hemorrhage were 94% & 96% for T2-weighted, 84% & 55% for LGE MRI and 85% & 56% for EGE MRI. Conclusions Bright blood T2-weighted MRI has high diagnostic accuracy for myocardial hemorrhage.

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“…3), a finding previously reported (6), reflecting the different factors involved in tissue iron distribution. In contrast to the findings presented by Galia et al (1), as well as by other investigators (7), no statistical correlation was found between ferritin and heart MRI.…”

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confidence: 62%

Evaluation of Iron Overload in β‐Thalassemia Patients Using Magnetic Resonance Imaging

Perifanis¹,

Economou²,

Christoforides³

et al. 2004

Hemoglobin

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Non-invasive myocardial iron assessment in thalassaemic patients: T2 relaxometry and magnetization transfer ratio measurements

Abstract: MTR measurements can be used to complement T2 measurements for non-invasive myocardial iron assessment.

Cited by 29 publications

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Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Bright-Blood T ₂ -Weighted MRI Has High Diagnostic Accuracy for Myocardial Hemorrhage in Myocardial Infarction

Evaluation of Iron Overload in β‐Thalassemia Patients Using Magnetic Resonance Imaging

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Non-invasive myocardial iron assessment in thalassaemic patients: T2 relaxometry and magnetization transfer ratio measurements

Abstract: MTR measurements can be used to complement T2 measurements for non-invasive myocardial iron assessment.

Cited by 29 publications

References 0 publications

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Bright-Blood T 2 -Weighted MRI Has High Diagnostic Accuracy for Myocardial Hemorrhage in Myocardial Infarction

Evaluation of Iron Overload in β‐Thalassemia Patients Using Magnetic Resonance Imaging

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Bright-Blood T ₂ -Weighted MRI Has High Diagnostic Accuracy for Myocardial Hemorrhage in Myocardial Infarction