Evaluation of Iron Overload in β‐Thalassemia Patients Using Magnetic Resonance Imaging

Perifanis, Vassilios; Economou, Marina; Christoforides, Athanassios; Koussi, Afrodite; Tsitourides, Ioannis; Athanassiou‐Metaxa, Miranda

doi:10.1081/hem-120028886

Cited by 10 publications

(10 citation statements)

References 8 publications

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“…Successful management and prevention of iron toxicity are dependent on accurate monitoring of patients. Monitoring strategies include invasive tests such as liver biopsy and the direct measurement of iron concentration, which is considered the "gold standard", or imaging studies including magnetic resonance imaging to assess iron loading in the liver and heart or magnetic biosusceptometry (SQUID), which provides a measurement of hepatic iron concentration [26,27]. However, these diagnostic tests are invasive, expensive, and subject to sampling errors.…”

Section: Discussionmentioning

confidence: 99%

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Anesthetic Management of an Adolescent With Diamond-Blackfan Syndrome During Posterior Spinal Fusion

et al. 2015

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Diamond-Blackfan syndrome (DBS) is a rare autosomal dominant ribosomal disorder. Patients present primarily with severe hypoplastic anemia and reticulocytopenia. Due to the craniofacial defects, cardiac pathology, short stature, and skeletal abnormalities, surgical and anesthetic care are frequently required. The associated structural anomalies and end-organ involvement may impact the perioperative care. We present an 18-year-old adolescent with Diamond-Blackfan anemia (DBA) who required anesthetic care for posterior spinal fusion. Previous reports of anesthetic care for these patients are reviewed, the end-organ involvement is discussed, and options for anesthetic care are presented.

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Section: Discussionmentioning

confidence: 99%

“…However, these diagnostic tests are invasive, expensive, and subject to sampling errors. As such, routine laboratory monitoring of plasma or serum ferritin concentration in the blood remains the most commonly used test for estimating iron burden [27][28][29][30][31]. This test is inexpensive, non-invasive, and almost universally available.…”

Section: Discussionmentioning

confidence: 99%

Anesthetic Management of an Adolescent With Diamond-Blackfan Syndrome During Posterior Spinal Fusion

et al. 2015

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“…Serum ferritin over 200 ng/mL in premenopausal women and over 300 ng/mL in men, combined with fasting transferrin saturation (TSAT) of more than 50% in women and over 60% in men are sensitive markers of excess iron [25,26]. Consistently high serial serum ferritin levels greater than 1,000 μg/L suggest iron overload [21,27,28]. Serial serum ferritin values greater than 1,000 μg/L are considered the threshold for initiation of iron reduction therapy in transfusion-dependent patients [13].…”

Section: Serum Ferritinmentioning

confidence: 99%

Iron overload and toxicity: implications for anesthesiologists

Shander

Berth

Betta

et al. 2012

Journal of Clinical Anesthesia

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“…In severe cases, in order to improve survival and quality of life of these patients, multiple blood transfusions accompanied by iron chelation are required [6]. However, regular transfusions can lead to severe iron accumulation in cells and tissues, and thus the patient's body iron status must be monitored in order to provide a proper management of the iron overload status [7, 8]. …”

Section: Introductionmentioning

confidence: 99%

“…Among these procedures, serum ferritin level is a commonly used measurement as it is minimally invasive, inexpensive, and widely available and can be performed frequently allowing regular monitoring, and the values correlate with total body iron store [8, 10]. Serum ferritin levels consistently >1000 μ g/L are indicative of iron overload [7, 10, 11]. …”

Section: Introductionmentioning

confidence: 99%

Relationship between Plasma Ferritin Level and Siderocyte Number in Splenectomizedβ-Thalassemia/HbE Patients

Tripatara

Srichana

Lamool

et al. 2012

Anemia

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Introduction. In iron overload status, excess iron deposits in reticuloendothelial cells and tissues and can be detected using Prussian blue staining. The aim of this paper was to investigate the relationship between siderocyte numbers and plasma ferritin levels (a practically standard marker of iron overload) in the blood of the splenectomized and nonsplenectomized β-thalassemia/HbE patients, who are at risk of iron overload. Methods. EDTA blood samples from 64 patients with 35 splenectomized and 29 nonsplenectomized β-thalassemia/HbE patients, who received regular blood transfusions, and 20 normal individuals were investigated for siderocyte numbers, plasma ferritin levels, and complete blood counts. Results. The average percent siderocytes in splenectomized and nonsplenectomized β-thalassemia/HbE patients were 11.5% and 0.08%, respectively, and plasma ferritin levels of 2,332 μg/L and 1,279 μg/L, respectively. Percent siderocytes showed a good correlation with plasma ferritin levels only in splenectomized patients (r = 0.69, P < 0.001). A receiver operating curve analysis from splenectomized patients' data indicated that siderocytes at 3% cut-off are the best predictor for plasma ferritin level ≥1,000 μg/L with 92.9% sensitivity and 42.9% specificity. Conclusion. Circulating siderocyte numbers can be used as a screening test for the assessment of the iron overload in splenectomized β-thalassemia/HbE patients in the place where serum ferritin is not available.

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Evaluation of Iron Overload in β‐Thalassemia Patients Using Magnetic Resonance Imaging

Cited by 10 publications

References 8 publications

Anesthetic Management of an Adolescent With Diamond-Blackfan Syndrome During Posterior Spinal Fusion

Anesthetic Management of an Adolescent With Diamond-Blackfan Syndrome During Posterior Spinal Fusion

Iron overload and toxicity: implications for anesthesiologists

Relationship between Plasma Ferritin Level and Siderocyte Number in Splenectomizedβ-Thalassemia/HbE Patients

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