Non-invasive intraocular pressure monitoring with a contact lens engineered with a nanostructured polymeric sensing film

Laukhin, V. N.; Sánchez, Irene; Moya, Ana; Laukhina, Elena; Martín, Raúl; Ussa, Fernando; Rovira, Concepció; Guimerà‐Brunet, Anton; Villa, Rosa; Aguiló, Jordi; Pastor, J. Carlos; Veciana, Jaume

doi:10.1016/j.sna.2011.05.021

Cited by 50 publications

(47 citation statements)

References 22 publications

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“…Laukhin et al [10] presented the first eye phantom developed for testing lens-based IOP measurement systems. In this phantom, the lens-based sensor is placed on a glass adapter.…”

Section: Eye Phantom State Of the Artmentioning

confidence: 99%

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

et al. 2017

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Developing electronic medical devices is challenging. Simulations or in vivo experiments are not sufficient to obtain pertinent comparisons between potential design options. This paper presents a new artificial tool allowing objective comparisons between electronic device topologies. The main idea is to build a tool which is sensitive to targeted biological parameters only. These tools are generally called phantoms. The phantom presented in this paper is dedicated to IntraOcular Pressure (IOP) Measurement devices used in glaucoma diagnosis and treatment. It is called Biomechanical Eye Emulator (BEE). The BEE emulates the main biomechanical parameters influencing the IOP measurements. Because it is not sensitive to the living context, the BEE is the most efficient tool to investigate the best sensor design. BEE specifications are defined to be as close as possible to chosen models (humans or animals). Its efficiency is shown with a case study on rabbits. The results clearly demonstrate the BEE phantoms efficacy in providing objective assessment metrics during the sensor design process.

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“…Laukhin et al [10] presented the first eye phantom developed for testing lens-based IOP measurement systems. In this phantom, the lens-based sensor is placed on a glass adapter.…”

Section: Eye Phantom State Of the Artmentioning

confidence: 99%

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

et al. 2017

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“…Although the bilayer film exhibited a higher degree of biocompatibility when compared with silicone, IOP measurements deviated slightly from linearity. 41,42 Nonetheless, the piezoresistive bilayer could potentially be combined with a variety of contact lens designs to enable the development of a noninvasive IOP-monitoring system.…”

Section: Intraocular Pressure Monitoringmentioning

confidence: 99%

Nanotechnology Applications for Glaucoma

Çetinel

Montemagno²

2016

Asia-Pacific Journal of Ophthalmology

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Glaucoma is the second leading cause of blindness worldwide, and the antiglaucoma treatments currently available suffer from various complications. Nanotechnology-based treatments show a great deal of promise in overcoming these complications and form the basis for next-generation glaucoma treatment strategies, with the help of applications such as controlled release, targeted delivery, increased bioavailability, diffusion limitations, and biocompatibility. Significant progress has been made in nanomedicine in the efficiency of antiglaucoma medications, nanofabrication systems such as microelectromechanical systems that remove the limitations of nanodevices, and tissue regeneration vesicles for developing glaucoma treatments not based on intraocular pressure. With the use of these advanced technologies, the prevention of glaucoma-induced blindness will be possible in the near future. Herein, we reviewed the recent advances in nanotechnology-based treatment strategies for glaucoma.

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“…Recently, we have reported the IOP sensing device [2] based on a rigid contact lens equipped with a flexible all-organic strain membrane sensor based on a bi layer (BL) film [6]. We would like to mention, that the developed device uses a different measure approach and, moreover, the gauge factor of its BL film-based sensing component is five times larger than the platinum gauge factor.…”

Section: Introductionmentioning

confidence: 99%

“…Although the HCL was equipped with the same sensing BL film as in [2], in the sensing lens fabrication, a new design approach has been used. This approach allowed the use of different parts of the same BL film gauge as the pressure sensor and temperature effect compensator.…”

mentioning

confidence: 99%

Hybrid contact lens capable of intraocular pressure monitoring in noninvasive way

Laukhin

Lebedev

Laukhina

et al. 2013

2013 Transducers &Amp; Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems

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The purpose of this paper is the development of devices for monitoring the intraocular pressure (IOP) variations in a non-invasive way. The importance of the problem is caused by the need of a glaucoma diagnostic by control of the IOP in patients. It has been shown [1] that monitoring of the IOP variations over 24 h may change the glaucoma management of patients.Here we present a new prototype of an IOP sensing device based on a commercial hybrid contact lens (HCL) that provides a greater comfort for patients. Although the HCL was equipped with the same sensing BL film as in [2], in the sensing lens fabrication, a new design approach has been used. This approach allowed the use of different parts of the same BL film gauge as the pressure sensor and temperature effect compensator.

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Non-invasive intraocular pressure monitoring with a contact lens engineered with a nanostructured polymeric sensing film

Cited by 50 publications

References 22 publications

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

Efficient Objective Metric Tool for Medical Electrical Device Development: Eye Phantom for Glaucoma Diagnosis Device

Nanotechnology Applications for Glaucoma

Hybrid contact lens capable of intraocular pressure monitoring in noninvasive way

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