Non‐invasive imaging of retinal blood flow in myeloproliferative neoplasms

Abstract

With non-invasive retinal imaging, we were able to demonstrate increased retinal venous blood velocity, increased retinal arterial blood oxygenation and normalization of intravascular reflectivity patterns after successful treatment of myeloproliferative neoplasms. Larger prospective studies are needed to assess the prognostic value of these non-invasive imaging methods in predicting circulatory complications in myeloproliferative neoplasms.

Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

“…Optical coherence tomography findings agree with previous studies of blood dyscrasia (Willerslev et al. ) and could indicate blunting of the normal parabolic blood flow rate at the highest IgM (Menke et al. ).…”

“…; Willerslev et al. ). The ordered signal is reduced or disappears when flow is turbulent, too high or too slow to induce order in the blood column or in cases of severe blood dyscrasia (Willerslev et al.…”

“…The ordered signal is reduced or disappears when flow is turbulent, too high or too slow to induce order in the blood column or in cases of severe blood dyscrasia (Willerslev et al. , ). It cannot be ruled out, however, that the change in blood composition per se may change the optical reflectivity of the intravascular blood column, and new OCT methods that apply Doppler technology (Tayyari et al.…”

“…In the absence of the normal structured intraluminal signal, the retrovascular shadow cast by the vessels is also weaker (Willerslev et al. ).…”

Retinal perfusion changes in radiation retinopathy

“…Recently, retinal blood oxygenation changes were also reported in patients with blood dyscrasia due to myeloproliferative neoplasms using non‐invasive retinal imaging (Willerslev et al. ).…”