Non-invasive fibrosis seromarkers as a predictor of liver fibrosis in chronic hepatitis C and/or non-alcoholic steatohepatitis

Ahmed, Lamiaa A.; Salama, H. S.; Ahmed, Rasha; Hamdy, Sherif; Alakel, Wafaa; Shafi, Sanaa Abdel; Mahgoub, Abeer; Hareedy, Amal; Fathy, Wael

doi:10.1016/j.ajg.2009.03.007

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Our review included 49 studies of diagnostic accuracy comparing ultrasound to histology (Table 1; Supporting Fig. 1)18‐66 and five studies comparing ultrasound to other radiological techniques (including three studies that reported three‐way comparisons between ultrasonography, another imaging technique, and histology) (Table 2). 67‐71 Nine of the 49 studies comparing ultrasound to histology also included data comparing each ultrasonographic parameter (e.g., liver‐to‐kidney contrast, deep beam attenuation, etc.)…”

Section: Resultsmentioning

confidence: 99%

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Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis

et al. 2011

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Ultrasonography is a widely accessible imaging technique for the detection of fatty liver, but the reported accuracy and reliability have been inconsistent across studies. We aimed to perform a systematic review and meta-analysis of the diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver. We used MEDLINE and Embase from October 1967 to March 2010. Studies that provided cross-tabulations of ultrasonography versus histology or standard imaging techniques, or that provided reliability data for ultra-sonography, were included. Study variables were independently abstracted by three reviewers and double checked by one reviewer. Forty-nine (4720 participants) studies were included for the meta-analysis of diagnostic accuracy. The overall sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio of ultrasound for the detection of moderate-severe fatty liver, compared to histology (gold standard), were 84.8% (95% confidence interval: 79.5-88.9), 93.6% (87.2-97.0), 13.3 (6.4-27.6), and 0.16 (0.12-0.22), respectively. The area under the summary receiving operating characteristics curve was 0.93 (0.91-0.95). Reliability of ultrasound for the detection of fatty liver showed kappa statistics ranging from 0.54 to 0.92 for intrarater reliability and from 0.44 to 1.00 for interrater reliability. Sensitivity and specificity of ultrasound was similar to that of other imaging techniques (i.e., computed tomography or magnetic resonance imaging). Statistical heterogeneity was present even after stratification for multiple clinically relevant characteristics. Conclusion Ultrasonography allows for reliable and accurate detection of moderate-severe fatty liver, compared to histology. Because of its low cost, safety, and accessibility, ultrasound is likely the imaging technique of choice for screening for fatty liver in clinical and population settings.

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Section: Resultsmentioning

confidence: 99%

“…67‐71 Nine of the 49 studies comparing ultrasound to histology also included data comparing each ultrasonographic parameter (e.g., liver‐to‐kidney contrast, deep beam attenuation, etc.) and histology 25, 26, 31, 34, 38, 40, 49, 61, 62. Finally, 22 studies provided data on intra‐ or interrater reliability (Supporting Table 2).…”

Section: Resultsmentioning

confidence: 99%