Comparison between galectin-3 and YKL-40 levels for the assessment of liver fibrosis in cirrhotic patients

Turco, Serena Del; Simone, Paolo De; Ghinolfi, Davide; Gaggini, Melania; Basta, Giuseppina

doi:10.1016/j.ajg.2021.03.002

Cited by 5 publications

(15 citation statements)

References 34 publications

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“…In fact, in our external cohort comprised of patients with a uniform aetiology (alcoholic hepatitis), galectin‐3 was significantly higher in severe AH. This reinforces the fact that galectin‐3 discriminates based on disease severity regardless of the aetiology, in accordance with other reported studies 14,15,19 …”

Section: Discussionsupporting

confidence: 92%

“…14,15,19 Previous reports have shown high galectin-3 levels in HCC; however, but in those, the extent of disease severity in these patients was not clear. 15,36 We found lower levels of galectin-3 in our CC patients, all of which had HCC. ).…”

Section: Ta B L E 2 Univariable Cox Regression Analyses For Post-tran...mentioning

confidence: 93%

“…Considering also that differential galectin-3 expression patterns could be observed even though patients with CC had HCC, we believe that the degree of cirrhosis disease severity is more relevant than the presence of HCC. 15 We acknowledge that the performance and usefulness of galectin-3 in the post-transplant setting will need to be tested in larger cohorts. Considering that the levels of galectin-3 vary with disease severity, it will also be relevant to carry out serial measurements to confirm its prognostic utility in patients with advanced liver disease and broaden its clinical applications.…”

Section: Ta B L E 2 Univariable Cox Regression Analyses For Post-tran...mentioning

confidence: 99%

“…Galectin‐3, originally identified as marker of inflammatory macrophages, 10 is an essential mediator in the activation of hepatic stellate cells 11 and plays an important role in liver fibrosis 12 . Levels of galectin‐3 are higher in cirrhosis compared to healthy controls and specially in patients with high Child–Pugh scores 13‐15 . Intrahepatic galectin‐3 has also been detected in hepatocellular carcinoma and in cirrhotic human liver biopsies 11,13,16 .…”

Section: Introductionmentioning

confidence: 99%

“…12 Levels of galectin-3 are higher in cirrhosis compared to healthy controls and specially in patients with high Child-Pugh scores. [13][14][15] Intrahepatic galectin-3 has also been detected in hepatocellular carcinoma and in cirrhotic human liver biopsies. 11,13,16 Galectin-3 has an important immunological role and has been shown to regulate innate and adaptive immune responses.…”

Section: Introductionmentioning

confidence: 99%

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Galectin‐3 is overexpressed in advanced cirrhosis and predicts post‐liver transplant infectious complications

Cervantes-Álvarez

Rosa

Vilatobá

et al. 2022

Liver International

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Background & Aims: Patients with advanced cirrhosis often have immune dysfunction and are more susceptible to infections. Galectin-3 is a β-galactoside-binding lectin implicated in inflammation, immune regulation and liver fibrosis. We aim to investigate galectin-3 expression in advanced cirrhosis and its ability to predict post-transplant infectious complications. Methods:We collected sera and liver samples from 129 cirrhotic patients at the time of liver transplantation and from an external cohort of 37 patients with alcoholic liver disease including alcoholic hepatitis (AH) at the time of diagnosis. Galectin-3 was assessed by ELISA, real-time PCR, immunohistochemistry and RNA-seq. Receiver operating characteristic curves and Cox proportional-hazards regression analysis were performed to assess the predictive power of galectin-3 for disease severity and posttransplant infections.Results: Increased galectin-3 levels were found in advanced cirrhosis. Galectin-3 significantly correlated with disease severity parameters and inflammatory markers.

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Section: Discussionsupporting

confidence: 92%

Section: Ta B L E 2 Univariable Cox Regression Analyses For Post-tran...mentioning

confidence: 93%

Section: Ta B L E 2 Univariable Cox Regression Analyses For Post-tran...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Galectin‐3 is overexpressed in advanced cirrhosis and predicts post‐liver transplant infectious complications

Cervantes-Álvarez

Rosa

Vilatobá

et al. 2022

Liver International

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Galectin-12 modulates Kupffer cell polarization to alter the progression of nonalcoholic fatty liver disease

Lee,

Wang,

Hsu

et al. 2023

Glycobiology

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Non-alcoholic fatty liver disease (NAFLD) is caused by an imbalance in lipid metabolism and immune response to pose a risk factor for liver fibrosis. Recent evidence indicates that M2 macrophages secrete transforming growth factor (TGF)-β1, which contributes to liver fibrosis. Galectin-12 (Gal12) has been demonstrated to regulate lipid metabolism and macrophage polarization. The purpose of this study is to investigate the role of Gal12 in the development of NAFLD and fibrosis. Liver tissue from wild-type C57BL/6 mice fed with a high-fat diet containing cholesterol and cholic acid diet (HFCCD) for 4–12 weeks was used to examine Gal12 expression and its correlation with NAFLD. Furthermore, the effects of Gal12 on M2 macrophages during the progression of NAFLD was investigated by studying Kupffer cells from Gal12 knockout mice and doxycycline-inducible Gal12−/–THP-1 cells. Ablation of Gal12 promoted M2 polarization of Kupffer cells, as indicated by higher levels of M2 markers, such as arginase I and chitinase 3-like protein 3. Furthermore, the activation of signal transducer and activator of transcription 6 was significantly higher in Gal12−/− macrophages activated by IL-4, which was correlated with higher levels of TGF-β1. Moreover, Gal12−/− macrophage-conditioned medium promoted hepatic stellate cells (HSCs) myofibroblast differentiation, which was indicated by higher α-SMA expression levels compared to those treated with LacZ control medium. Finally, we demonstrated that Gal12 knockdown negatively regulated the suppressor of cytokine signaling 3 levels. These findings suggested that Gal12 balances M1/M2 polarization of Kupffer cells to prevent NAFLD progression.

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What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2022? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society

et al. 2022

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Comparison between galectin-3 and YKL-40 levels for the assessment of liver fibrosis in cirrhotic patients

Cited by 5 publications

References 34 publications

Galectin‐3 is overexpressed in advanced cirrhosis and predicts post‐liver transplant infectious complications

Galectin‐3 is overexpressed in advanced cirrhosis and predicts post‐liver transplant infectious complications

Galectin-12 modulates Kupffer cell polarization to alter the progression of nonalcoholic fatty liver disease

What Is Hot and New in Basic and Translational Science in Liver Transplantation in 2022? Report of the Basic and Translational Research Committee of the International Liver Transplantation Society

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