Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation

Abstract

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Diagnostic usefulness of FibroMeter VCTE for hepatic fibrosis in patients with nonalcoholic fatty liver disease

“…In particular, the cost of each strategy should be evaluated carefully in relation to the final clinical outcomes. Although few data are available on the costeffectiveness of different noninvasive strategies for detecting liver fibrosis [25], it is conceivable that methods incorporating a TE examination would be more costly than a simple score such as NFSA. From a purely clinical standpoint, it is obvious that the most effective method is FibroMeter VCTE in NAFLD Dincses and Yilmaz www.eurojgh.com the one that can detect the highest number of patients with severe fibrosis with maximum accuracy.…”

Nonalcoholic fatty liver disease and bariatric surgery: a comprehensive review

“…Thus, this score is quite adequate for populationbased studies and for clinical screening and follow-up purposes. 17,84,85 Despite recent developments in noninvasive methods for assessing NAFLD, liver biopsy remains the gold-standard method for diagnosing and characterizing it, since it may provide a nuanced evaluation that no other method is capable of today. On the other hand, it is expensive and highly invasive, and carries significant risk of morbidity and even mortality.…”

Asian-Pacific Association for the Study of the Liver (APASL) consensus guidelines on invasive and non-invasive assessment of hepatic fibrosis: a 2016 update

“…Stevenson et al [158] have conducted a systematic review and an economic evaluation of the diagnostic accuracy, cost-effectiveness and effect on patient outcomes of four non-invasive tests for liver fibrosis in patients with suspected alcohol-related liver disease. These tests include the ELF, FibroTest, FibroMAX and TE.…”

“…These tests include the ELF, FibroTest, FibroMAX and TE. The authors concluded that no conclusive result could be provided on the most cost-effective strategy until further data are available [158]. Canavan et al [159] used a Markov decision analytic model to simulate a hypothetical cohort of 10,000 patients with chronic HCV initially without fibrosis over their lifetime and reported the cost-effectiveness of annual surveillance for cirrhosis in patients with chronic HCV.…”