Non‐invasive Diagnosis of Ischemic Brain Damage After Cardiopulmonary Resuscitation in Dogs by Using Transcranial Doppler Ultrasonography

Fukushima, U; Sasaki, Shu; Okano, Shozo; Oyamada, Toshifumi; Yoshikawa, Takashi; Hagio, Mitsuyoshi; Takase, Katsuaki

doi:10.1111/j.1740-8261.2000.tb01473.x

Cited by 22 publications

(26 citation statements)

References 17 publications

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“…3±3.8 cm/s), EDV (13.5±3.1 cm/s), and resistive index (0.51±0.07) in the middle cerebral artery were lower than in our dogs; a 5 MHz probe was used. In evaluation of cerebral blood flow velocities in the middle cerebral and basilar artery of dogs after 3 and 12 min of cardiac arrest, values of PSV and PI for the middle cerebral artery were lower than in our dogs 17 . Conversely, the values of MV and EDV were similar to those achieved in our work.…”

Section: Discussionsupporting

confidence: 85%

Assessing Circle of Willis Blood Circulation in Dogs With Transcranial Color‐coded Duplex Sonography

Duque

Dominguez-Roldan

Ruiz

et al. 2009

Vet Radiology Ultrasound

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Insonation of Circle of Willis by transcranial Doppler duplex color sonography is described in 30 healthy dogs with 15 weighing < 33 lb and 15 weighing >33 lb. Imaging was via a temporal window to explore the rostral, middle, and caudal cerebral arteries on both the left and right-hand sides; and through an suboccipital window to study the basilar artery. Normal mean values of the peak systolic velocity (PSV), end diastolic velocity, mean velocity, resistance index (RI), and pulsatility index (PI) were characterized and compared with those obtained in previous studies. There was significant differences in the PSV, RI, and PI in the rostral cerebral artery between dogs weighing < 33 vs. > 33 lb. Mean PSV was higher in weighing over 33 lb, whereas the mean resistive index and mean PI were lower in these dogs.

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Section: Discussionsupporting

confidence: 85%

Assessing Circle of Willis Blood Circulation in Dogs With Transcranial Color‐coded Duplex Sonography

Duque

Dominguez-Roldan

Ruiz

et al. 2009

Vet Radiology Ultrasound

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“…A tentative diagnosis of ICH was based on history, neurologic examination (performed by a board-certified neurologist) and/or magnetic resonance or computed tomographic imaging studies (evaluated by a board-certified radiologist or neurologist). Criteria to substantiate suspicion of ICH were a forebrain or multifocal localization with severely reduced consciousness and miotic pupils on neurological exam, Cushing triad (irregular respiration, bradycardia, and systolic hypertension), brain herniation or other shifts of brain parenchyma on MRI or CT [20], an elevated resistive index [21], and deterioration of modified Glasgow coma scale scores [22]. The decision to administer osmotherapy was at the clinicians’ discretion.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study

et al. 2017

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BackgroundHyperosmolar therapy with either mannitol or hypertonic saline (HTS) is commonly used in the treatment of intracranial hypertension (ICH). In vitro data indicate that both mannitol and HTS affect coagulation and platelet function in dogs. The aim of this study was to compare the effects of 20% mannitol and 7.2% HTS on whole blood coagulation using rotational thromboelastometry (ROTEM®) and platelet function using a platelet function analyzer (PFA®) in dogs with suspected ICH. Thirty client-owned dogs with suspected ICH needing osmotherapy were randomized to receive either 20% mannitol (5 ml/kg IV over 15 min) or 7.2% HTS (4 ml/kg IV over 5 min). ROTEM® (EXTEM® and FIBTEM® assays) and PFA® analyses (collagen/ADP cartridges) were performed before (T0), as well as 5 (T5), 60 (T60) and 120 (T120) minutes after administration of HTS or mannitol. Data at T5, T60 and T120 were analyzed as a percentage of values at T0 for comparison between groups, and as absolute values for comparison between time points, respectively.ResultsNo significant difference was found between the groups for the percentage change of any parameter at any time point except for FIBTEM® clotting time. Within each group, no significant difference was found between time points for any parameter except for FIBTEM® clotting time in the HTS group, and EXTEM® and FIBTEM® maximum clot firmness in the mannitol group. Median ROTEM® values lay within institutional reference intervals in both groups at all time points, whereas median PFA® values were above the reference intervals at T5 (both groups) and T60 (HTS group).ConclusionsUsing currently recommended doses, mannitol and HTS do not differ in their effects on whole blood coagulation and platelet function in dogs with suspected ICH. Moreover, no relevant impairment of whole blood coagulation was found following treatment with either solution, whereas a short-lived impairment of platelet function was found after both solutions.

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“…A significant correlation between ICP and resistance index was demonstrated in dogs [11]. Recent report suggested that TCD recording in the basilar artery may be used to predict outcome and the diagnosis of brain damage in dogs [12]. However, there are technical limitations inherent in Doppler imaging methods.…”

mentioning

confidence: 99%

Quantitative Evaluation of Contrast Enhanced Transcranial Doppler Signal using Galactose Based Echo-Contrast Agent in Dogs

Chung

Choi

Lee

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Transcranial Doppler ultrasonography (TCD) is hindered by insufficient ultrasound penetration through the temporal bone. The use of echo-contrast agents to enhance the Doppler signal is an important step toward the solution of this problem. The aim of the present study was to investigate the tolerability and diagnostic value of the intravenous echo-contrast agent, Levovist ® . Levovist ® was administered intravenously in 8 dogs with two doses (0.2 and 0.3 ml/kg) at different concentrations (300 and 400 mg/ml). In right middle cerebral artery (RMCA), the duration and degree of the signal enhancement were measured by TCD. All 32 administrations of Levovist ® produced an increase in TCD signal of the RMCA without complications. The first assessable pulse curve could be seen on the screen after 4 to 7 seconds after injection. There was no significant difference of latency period between different concentration and dosage. The signal amplitude was increased homogeneously by more than 30 dB when 0.3 ml/kg with 300 mg/ml concentration of Levovist ® and 0.2 and 0.3 ml/kg with 400 mg/ml concentration were administered. There was no significant difference in the duration of optimal contrasting between 0.3 ml/kg with 300 mg/ml concentration of Levovist ® and 0.2 and 0.3 ml/kg with 400 mg/ml concentration. The duration of the signal enhancement was 144 to 422 seconds, depending on the degree of concentration and dose of administration. Optimal TCD signal enhancement of RMCA was obtained using 0.3 ml/kg with 300 mg/ml concentration of Levovist ® in dogs, which is considered to provide quality visualization. KEY WORDS: canine, galactose based echo-contrast agent, right middle cerebral artery, transcranial Doppler.

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Non‐invasive Diagnosis of Ischemic Brain Damage After Cardiopulmonary Resuscitation in Dogs by Using Transcranial Doppler Ultrasonography

Cited by 22 publications

References 17 publications

Assessing Circle of Willis Blood Circulation in Dogs With Transcranial Color‐coded Duplex Sonography

Assessing Circle of Willis Blood Circulation in Dogs With Transcranial Color‐coded Duplex Sonography

Comparison of the effects of 7.2% hypertonic saline and 20% mannitol on whole blood coagulation and platelet function in dogs with suspected intracranial hypertension - a pilot study

Quantitative Evaluation of Contrast Enhanced Transcranial Doppler Signal using Galactose Based Echo-Contrast Agent in Dogs

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