Non-invasive detection of glucose<i>via</i>a solution-gated graphene transistor

Ma, Mingyu; Zhou, Yang; Li, Jinhua; Ge, Zhiqi; He, Hanping; Tian, Tao; Cai, Zhiwei; Wang, Xianbao; Chang, Gang; He, Yunbin

doi:10.1039/c9an01754b

Cited by 27 publications

(19 citation statements)

References 47 publications

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“…Small biomolecules are essential chemicals with molecular weights of less than 1 kDa or 500 (relative molecular mass) in life entities. , Among them, the most important ones are glucose, dopamine (DA), adenosine triphosphate, and amino acids Table summarizes the latest advances in 2D FET small-biomolecule sensors and their sensing performance.…”

Section: Biological Sensorsmentioning

confidence: 99%

Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization

2022

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The evolutionary success in information technology has been sustained by the rapid growth of sensor technology. Recently, advances in sensor technology have promoted the ambitious requirement to build intelligent systems that can be controlled by external stimuli along with independent operation, adaptivity, and low energy expenditure. Among various sensing techniques, field-effect transistors (FETs) with channels made of two-dimensional (2D) materials attract increasing attention for advantages such as label-free detection, fast response, easy operation, and capability of integration. With atomic thickness, 2D materials restrict the carrier flow within the material surface and expose it directly to the external environment, leading to efficient signal acquisition and conversion. This review summarizes the latest advances of 2D-materials-based FET (2D FET) sensors in a comprehensive manner that contains the material, operating principles, fabrication technologies, proof-of-concept applications, and prototypes. First, a brief description of the background and fundamentals is provided. The subsequent contents summarize physical, chemical, and biological 2D FET sensors and their applications. Then, we highlight the challenges of their commercialization and discuss corresponding solution techniques. The following section presents a systematic survey of recent progress in developing commercial prototypes. Lastly, we summarize the long-standing efforts and prospective future development of 2D FET-based sensing systems toward commercialization.

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Section: Biological Sensorsmentioning

confidence: 99%

Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization

2022

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“…A number of studies highlighted noninvasive glucose detection in diabetic patients, and they systematically replaced the conventional and mostly invasive measurement methods (e.g., finger pricking for drawing blood) [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. While some patients may require from six to eight glucose measurements per day for multiple-dose insulin injections or insulin pump therapy, this test is not frequently performed due to the inconvenience that it involves, especially for children [ 62 , 63 ].…”

Section: Contact Lenses For Glucose Detectionmentioning

confidence: 99%

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

et al. 2022

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In recent years, wearable contact lenses for medical applications have attracted significant attention, as they enable continuous real-time recording of physiological information via active and noninvasive measurements. These devices play a vital role in continuous monitoring of intraocular pressure (IOP), noninvasive glucose monitoring in diabetes patients, drug delivery for the treatment of ocular illnesses, and colorblindness treatment. In specific, this class of medical devices is rapidly advancing in the area of drug loading and ocular drug release through incorporation of electrospun fibers. The electrospun fiber matrices offer a high surface area, controlled morphology, wettability, biocompatibility, and tunable porosity, which are highly desirable for controlled drug release. This article provides an overview of the advances of contact lens devices in medical applications with a focus on four main applications of these soft wearable devices: (i) IOP measurement and monitoring, (ii) glucose detection, (iii) ocular drug delivery, and (iv) colorblindness treatment. For each category and application, significant challenges and shortcomings of the current devices are thoroughly discussed, and new areas of opportunity are suggested. We also emphasize the role of electrospun fibers, their fabrication methods along with their characteristics, and the integration of diverse fiber types within the structure of the wearable contact lenses for efficient drug loading, in addition to controlled and sustained drug release. This review article also presents relevant statistics on the evolution of medical contact lenses over the last two decades, their strengths, and the future avenues for making the essential transition from clinical trials to real-world applications.

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“…electrostatic potential 43 considering the gate as the reference voltage. This capacitive contribution is very high in graphene, therefore this mechanism can be successfully exploited for several kinds of sensing applications, ranging from pH sensing [44][45][46][47] to biosensing, [48][49][50][51][52][53] thus making this device a versatile and convenient alternative to standard sensors. Fig.…”

Section: The Organic Electrochemical Transistor (Oect)mentioning

confidence: 99%

Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications

2021

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Non-invasive detection of glucoseviaa solution-gated graphene transistor

Abstract: Owing to its high sensitivity, a solution-gated graphene transistor has rapidly emerged as a cutting edge technology in electrochemical sensing.

Cited by 27 publications

References 47 publications

Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization

Two-Dimensional Field-Effect Transistor Sensors: The Road toward Commercialization

A Meta-Analysis of Wearable Contact Lenses for Medical Applications: Role of Electrospun Fiber for Drug Delivery

Interfacing cells with organic transistors: a review ofin vitroandin vivoapplications

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