Non-invasive brain stimulation shows possible cerebellar contribution in transfer of prism adaptation after-effects from pointing to throwing movements

Fleury, Laurent; Panico, Francesco; Foncelle, Alexandre; Revol, Patrice; Delporte, Ludovic; Jacquin-Courtois, Sophie; Collet, Christian; Rossetti, Yves

doi:10.1016/j.bandc.2021.105735

Cited by 5 publications

(11 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specific pointing and throwing conditions for each stage of the experimental protocol are detailed in the following section and illustrated in Figure 1 . See also Fleury et al (2021) for more detailed information about the task set-ups.…”

Section: Methodsmentioning

confidence: 99%

“…During pre-tests and post-tests, we computed terminal errors by grouping the right and central targets as a previous study using the same procedures reported no difference between targets (Fleury et al, 2020(Fleury et al, , 2021. We conducted a specific analysis of pointing trajectories for right and central targets as the initial directions and the length of trajectories were intrinsically dependent on the target position.…”

Section: Pointing Kinematics Analysismentioning

confidence: 99%

“…The literature on the mechanisms and brain networks involved during PA includes a plethora of studies ranging from theoretical papers describing models of PA ( Welch, 1974 ; Redding and Wallace, 2001 ; Redding et al, 2005 ; Petitet et al, 2017 ), to neurological lesion ( Weiner et al, 1983 ; Baizer et al, 1999 ; Pisella et al, 2004 , 2005 ; Newport and Jackson, 2006 ; Hanajima et al, 2015 ), neuroimaging ( Clower et al, 1996 ; Danckert et al, 2008 ; Luauté et al, 2009 ; Chapman et al, 2010 ; Küper et al, 2014 ) and neurostimulation studies ( Panico et al, 2016 , 2018a , b , 2022 ; Fleury et al, 2021 ). Evidence from these studies converge toward two processes at work during PA: a rapid process of strategic control responsible for quick error reduction during the very first trials of exposure and a slower process of realignment accounting for complete correction of errors during exposure and after-effect development ( Prablanc et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, experts in throwing (dart players) did instead show transfer from throwing to pointing. In a second study, Fleury et al (2021) showed that cathodal cerebellar transcranial Direct Current Stimulation (tDCS) partially reduced transfer of after-effects from pointing to throwing in healthy participants. Taken together, results from these two studies question whether the processes of transfer could be boosted by facilitatory brain stimulation.…”

Section: Introductionmentioning

confidence: 99%

“…The aim of the present study was to investigate the functional role of the cerebellum in the inter-task transfer of after-effects from throwing to pointing during PA by using anodal tDCS. Based on our previous findings on after-effects transfer ( Fleury et al, 2020 , 2021 ) and on previous stimulation studies on visuomotor adaptation ( Galea et al, 2011 ; Panico et al, 2016 , 2018a , b ; Leow et al, 2017 ) we hypothesized that anodal cerebellar tDCS would have a boosting effect, promoting transfer from throwing to pointing in non-expert participants. Investigating the neural correlates of after-effects transfer would provide crucial information on the nature and locus of adaptive processes allowing individuals to face a perturbation during exposure, and relevant clues about the adjustment of internal representations following sensorimotor adaptation ( Poggio and Bizzi, 2004 ; Redding and Wallace, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Fleury

Panico²,

Foncelle³

et al. 2022

Front. Psychol.

Self Cite

View full text Add to dashboard Cite

Prism Adaptation (PA) is a useful method to study the mechanisms of sensorimotor adaptation. After-effects following adaptation to the prismatic deviation constitute the probe that adaptive mechanisms occurred, and current evidence suggests an involvement of the cerebellum at this level. Whether after-effects are transferable to another task is of great interest both for understanding the nature of sensorimotor transformations and for clinical purposes. However, the processes of transfer and their underlying neural substrates remain poorly understood. Transfer from throwing to pointing is known to occur only in individuals who had previously reached a good level of expertise in throwing (e.g., dart players), not in novices. The aim of this study was to ascertain whether anodal stimulation of the cerebellum could boost after-effects transfer from throwing to pointing in novice participants. Healthy participants received anodal or sham transcranial direction current stimulation (tDCS) of the right cerebellum during a PA procedure involving a throwing task and were tested for transfer on a pointing task. Terminal errors and kinematic parameters were in the dependent variables for statistical analyses. Results showed that active stimulation had no significant beneficial effects on error reduction or throwing after-effects. Moreover, the overall magnitude of transfer to pointing did not change. Interestingly, we found a significant effect of the stimulation on the longitudinal evolution of pointing errors and on pointing kinematic parameters during transfer assessment. These results provide new insights on the implication of the cerebellum in transfer and on the possibility to use anodal tDCS to enhance cerebellar contribution during PA in further investigations. From a network approach, we suggest that cerebellum is part of a more complex circuitry responsible for the development of transfer which is likely embracing the primary motor cortex due to its role in motor memories consolidation. This paves the way for further work entailing multiple-sites stimulation to explore the role of M1-cerebellum dynamic interplay in transfer.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Pointing Kinematics Analysismentioning

confidence: 99%