Engagement of a parieto-cerebellar network in prism adaptation. A double-blind high-definition transcranial direct current stimulation study on healthy individuals

Panico, Francesco; Sagliano, Laura; Sorbino, Gaia; Trojano, Luigi

doi:10.1016/j.cortex.2021.10.005

Cited by 7 publications

(8 citation statements)

References 44 publications

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“…This interpretation goes against the idea of a clear-cut separation of the involvement of distinct brain areas in PA processes as depicted in classical models (Clower et al, 1996;Redding et al, 2005;Danckert et al, 2008;Luauté et al, 2009;Chapman et al, 2010;Küper et al, 2014) and is rather in favor of dynamic interconnections between several areas. This would be in line with previous stimulation studies probing the existence of a cerebello-parietal circuitry involved in PA using multiple-sites stimulation targeting both areas either with opposite (bi-cephalic stimulation; Panico et al, 2018a) or concurrent polarities (using HD-tDCS; Panico et al, 2022). These findings were supported by neuroimaging insights that highlighted the modulation of a cerebello-parieto-parahippocampal network during PA (Schintu et al, 2020).…”

Section: Opened Perspectives From a Network Approachsupporting

confidence: 89%

“…While the present study is a purely behavioral investigation, further work using computational modeling methods would help to reduce inter-individual variability in the responsiveness to the stimulation and offer to go deeper in the mechanistic explanations related to the efficacy of the stimulation on PA and transfer. In addition, as conventional tDCS is limited in terms of spatial resolution, modern high-definition tDCS montages might be useful to selectively target specific cerebellar regions and limit the current spreading ( Panico et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…Frontiers in Psychology 11 frontiersin.org specific cerebellar regions and limit the current spreading (Panico et al, 2022).…”

Section: General Interpretation and Limitationsmentioning

confidence: 99%

“…The literature on the mechanisms and brain networks involved during PA includes a plethora of studies ranging from theoretical papers describing models of PA ( Welch, 1974 ; Redding and Wallace, 2001 ; Redding et al, 2005 ; Petitet et al, 2017 ), to neurological lesion ( Weiner et al, 1983 ; Baizer et al, 1999 ; Pisella et al, 2004 , 2005 ; Newport and Jackson, 2006 ; Hanajima et al, 2015 ), neuroimaging ( Clower et al, 1996 ; Danckert et al, 2008 ; Luauté et al, 2009 ; Chapman et al, 2010 ; Küper et al, 2014 ) and neurostimulation studies ( Panico et al, 2016 , 2018a , b , 2022 ; Fleury et al, 2021 ). Evidence from these studies converge toward two processes at work during PA: a rapid process of strategic control responsible for quick error reduction during the very first trials of exposure and a slower process of realignment accounting for complete correction of errors during exposure and after-effect development ( Prablanc et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Fleury

Panico²,

Foncelle³

et al. 2022

Front. Psychol.

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Prism Adaptation (PA) is a useful method to study the mechanisms of sensorimotor adaptation. After-effects following adaptation to the prismatic deviation constitute the probe that adaptive mechanisms occurred, and current evidence suggests an involvement of the cerebellum at this level. Whether after-effects are transferable to another task is of great interest both for understanding the nature of sensorimotor transformations and for clinical purposes. However, the processes of transfer and their underlying neural substrates remain poorly understood. Transfer from throwing to pointing is known to occur only in individuals who had previously reached a good level of expertise in throwing (e.g., dart players), not in novices. The aim of this study was to ascertain whether anodal stimulation of the cerebellum could boost after-effects transfer from throwing to pointing in novice participants. Healthy participants received anodal or sham transcranial direction current stimulation (tDCS) of the right cerebellum during a PA procedure involving a throwing task and were tested for transfer on a pointing task. Terminal errors and kinematic parameters were in the dependent variables for statistical analyses. Results showed that active stimulation had no significant beneficial effects on error reduction or throwing after-effects. Moreover, the overall magnitude of transfer to pointing did not change. Interestingly, we found a significant effect of the stimulation on the longitudinal evolution of pointing errors and on pointing kinematic parameters during transfer assessment. These results provide new insights on the implication of the cerebellum in transfer and on the possibility to use anodal tDCS to enhance cerebellar contribution during PA in further investigations. From a network approach, we suggest that cerebellum is part of a more complex circuitry responsible for the development of transfer which is likely embracing the primary motor cortex due to its role in motor memories consolidation. This paves the way for further work entailing multiple-sites stimulation to explore the role of M1-cerebellum dynamic interplay in transfer.

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Section: Opened Perspectives From a Network Approachsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

“…Frontiers in Psychology 11 frontiersin.org specific cerebellar regions and limit the current spreading (Panico et al, 2022).…”

Section: General Interpretation and Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Fleury

Panico²,

Foncelle³

et al. 2022

Front. Psychol.

Self Cite

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“…In a third study, anodal or cathodal tDCS was applied simultaneously over the left parietal cortex and the right cerebellum during the whole PA procedure. The comparison of the two conditions showed reduction of terminal errors during exposure to prims under anodal and reduction of the aftereffect under cathodal tDCS, indicating the contribution of the parieto-cerebellar network both to recalibration and realignment processes ( Panico et al, 2022 ). These three studies highlighted the contribution of the right cerebellum and of the left parietal cortex to R-PA. Their results are compatible with our model, which posits critical reorganization within the left parietal cortex during R-PA.…”

Section: Prism-induced Topographical Mismatch Reshuffles Spatial Repr...mentioning

confidence: 99%

Choosing Sides: Impact of Prismatic Adaptation on the Lateralization of the Attentional System

Clarke

Farron²,

Crottaz-Herbette³

2022

Front. Psychol.

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Seminal studies revealed differences between the effect of adaptation to left- vs. right-deviating prisms (L-PA, R-PA) in normal subjects. Whereas L-PA leads to neglect-like shift in attention, demonstrated in numerous visuo-spatial and cognitive tasks, R-PA has only minor effects in specific aspects of a few tasks. The paucity of R-PA effects in normal subjects contrasts with the striking alleviation of neglect symptoms in patients with right hemispheric lesions. Current evidence from activation studies in normal subjects highlights the contribution of regions involved in visuo-motor control during prism exposure and a reorganization of spatial representations within the ventral attentional network (VAN) after the adaptation. The latter depends on the orientation of prisms used. R-PA leads to enhancement of the ipsilateral visual and auditory space within the left inferior parietal lobule (IPL), switching thus the dominance of VAN from the right to the left hemisphere. L-PA leads to enhancement of the ipsilateral space in right IPL, emphasizing thus the right hemispheric dominance of VAN. Similar reshaping has been demonstrated in patients. We propose here a model, which offers a parsimonious explanation of the effect of L-PA and R-PA both in normal subjects and in patients with hemispheric lesions. The model posits that prismatic adaptation induces instability in the synaptic organization of the visuo-motor system, which spreads to the VAN. The effect is lateralized, depending on the side of prism deviation. Successful pointing with prisms implies reaching into the space contralateral, and not ipsilateral, to the direction of prism deviation. Thus, in the hemisphere contralateral to prism deviation, reach-related neural activity decreases, leading to instability of the synaptic organization, which induces a reshuffling of spatial representations in IPL. Although reshuffled spatial representations in IPL may be functionally relevant, they are most likely less efficient than regular representations and may thus cause partial dysfunction. The former explains, e.g., the alleviation of neglect symptoms after R-PA in patients with right hemispheric lesions, the latter the occurrence of neglect-like symptoms in normal subjects after L-PA. Thus, opting for R- vs. L-PA means choosing the side of major IPL reshuffling, which leads to its partial dysfunction in normal subjects and to recruitment of alternative or enhanced spatial representations in patients with hemispheric lesions.

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Investigating Cerebello-Frontal Circuits Associated with Emotional Prosody: A Double-Blind tDCS and fNIRS study

Panico,

Luciano,

Salzillo

et al. 2024

Cerebellum

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The emotional and cognitive cerebellum has been explored by several studies in the past years. Recent evidence suggested the possible contribution of the cerebellum in processing emotional prosody, namely the ability to comprehend the emotional content of a given vocal utterance, likely mediated by anatomical and functional cerebello-prefrontal connections. In the present study, the involvement of a functional cerebello-prefrontal network in recognising emotional prosody was assessed by combining non-invasive anodal transcranial direct current stimulation (tDCS) over the right or the left cerebellum and functional Near Infrared Spectroscopy of the prefrontal cortex, in a double-blind within-subject experimental design on healthy participants. The results showed that right and, to a less extent, left cerebellar tDCS (as compared to sham stimulation) reduced neural activation in the prefrontal cortex while accuracy and reaction times at the vocal recognition task remained unchanged. These findings highlight functional properties of the cerebello-frontal connections and the psychophysiological effects of cerebellar brain stimulation, with possible clinical applications in psychiatric and neurological conditions.

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Engagement of a parieto-cerebellar network in prism adaptation. A double-blind high-definition transcranial direct current stimulation study on healthy individuals

Cited by 7 publications

References 44 publications

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Does anodal cerebellar tDCS boost transfer of after-effects from throwing to pointing during prism adaptation?

Choosing Sides: Impact of Prismatic Adaptation on the Lateralization of the Attentional System

Investigating Cerebello-Frontal Circuits Associated with Emotional Prosody: A Double-Blind tDCS and fNIRS study

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