Non-inheritable risk factors during pregnancy for congenital heart defects in offspring: A matched case-control study

Feng, Yu; Cai, Jun; Tong, Xiaojiao; Chen, Runsen; Zhu, Yu; Xu, Bing; Mo, Xuming

doi:10.1016/j.ijcard.2018.04.003

Cited by 18 publications

(26 citation statements)

References 39 publications

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“…This has been studied extensively using epidemiology in a variety of human populations. Overall, there is some evidence suggesting that maternal folic acid supplementation during pregnancy might result in lowering CHD risk by as much as 50% (Mao et al 2017;Parnell and Correa 2017;Feng et al 2018). However, this conclusion is still somewhat controversial, as other studies have not replicated these results (Jenkins et al 2007;Øyen et al 2019).…”

Section: Vitamin Amentioning

confidence: 99%

Environmental Risk Factors for Congenital Heart Disease

Kalisch-Smith

Ved

Sparrow

2019

Cold Spring Harb Perspect Biol

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Congenital heart disease (CHD) has many forms and a wide range of causes. Clinically, it is important to understand the causes. This allows estimation of recurrence rate, guides treatment options, and may also be used to formulate public health advice to reduce the population prevalence of CHD. The recent advent of sophisticated genetic and genomic methods has led to the identification of more than 100 genes associated with CHD. However, despite these great strides, to date only one-third of CHD cases have been shown to have a simple genetic cause. This is because CHD can also be caused by oligogenic factors, environmental factors, and/or gene-environment interaction. Although solid evidence for environmental causes of CHD have been available for almost 80 years, it is only very recently that the molecular mechanisms for these risk factors have begun to be investigated. In this review, we describe the most important environmental CHD risk factors, and what is known about how they cause CHD.

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Section: Vitamin Amentioning

confidence: 99%

Environmental Risk Factors for Congenital Heart Disease

Kalisch-Smith

Ved

Sparrow

2019

Cold Spring Harb Perspect Biol

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“…1). The 16 studies, including 11,911 cases and 74,358 controls, were finally identified as eligible in the analyses [10–25], covering a period from 1989 to 2018. All the 16 included studies were case–control studies.…”

Section: Resultsmentioning

confidence: 99%

“…Upper respiratory tract infection and influenza always outbreak seasonally, in which season pregnant women are susceptible to the infection [7–9]. Previous studies have explored the relationship between maternal upper respiratory tract infection during pregnancy and the risk of CHD [10–25]. A number of evidence seemed to support the association [11, 16, 19, 20, 22, 23], however, a few other studies did not establish the relationship [12, 13].…”

Section: Introductionmentioning

confidence: 99%

“…A number of evidence seemed to support the association [11, 16, 19, 20, 22, 23], however, a few other studies did not establish the relationship [12, 13]. Similarly, findings on the association between influenza during pregnancy and CHD was also controversial [11, 13–15, 18–21, 24, 25]. Almost all these studies took all CHD types as a whole.…”

Section: Introductionmentioning

confidence: 99%

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Associations of maternal upper respiratory tract infection/influenza during early pregnancy with congenital heart disease in offspring: evidence from a case-control study and meta-analysis

Xia

Zhao

et al. 2019

BMC Cardiovasc Disord

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BackgroundEvidences regarding the associations between maternal upper respiratory tract infection/influenza during pregnancy and the risk of congenital heart disease (CHD) is still controversial. This study was specifically designed to examine the associations by a case-control study and a meta-analysis of the published evidences and our finding.MethodsA hospital-based case-control study involving 262 children with simple CHD and 262 children with complex CHD, along with 262 control children, was conducted through June, 2016 to December, 2017. All children were aged 0–2 years old. Furthermore, a meta-analysis based on both previously published studies and our case-control study was performed.ResultsIn the case-control study, after adjusting for possible confounders, maternal upper respiratory tract infection/influenza during early pregnancy was found to be related to an increased risk of CHD (OR = 3.40 and 95% CI: 2.05–5.62 for simple CHD; OR = 2.39 and 95% CI: 1.47–3.88 for complex CHD). After a meta-analysis, the adverse impact was still kept significant (OR = 1.47 and 95% CI: 1.28–1.67 for simple CHD; OR = 1.44 and 95% CI: 1.14–1.75 for complex CHD). The very similar associations were also observed among single type of CHD, herein, ventricular septal defects (VSD) and tetralogy of fallot (TOF) in the case-control study. In the subsequent meta-analysis, however, the significant association only existed in VSD.ConclusionsAlthough there is still conflicting in TOF, the results are overall consistent, which provide new enforced evidence that maternal upper respiratory tract infection/influenza during early pregnancy, in general, play an important role in the occurrence of CHD.

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“…3. Paternal active smoking (OR = 1.967, 95% CI: 1.357~2.850) has been proven to be associated with an increased risk of CHD 27,28 . Bundhun PK et al 29 found that the mechanism of smoking may be related to the quantity and quality of sperm.…”

Section: Discussionmentioning

confidence: 99%

Parental non-hereditary teratogenic exposure factors on the occurrence of congenital heart disease in the offspring in the northeastern Sichuan, China

Liang

et al. 2020

Sci Rep

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nonhereditary factors play an important role in the occurrence of congenital heart disease (cHD). this study was to explore the possible parental nonhereditary exposure factors relevant to the occurrence of CHD in the northeastern Sichuan area. A total of 367 children with CHD and 367 children without congenital malformations aged 0 to 14 years old were recruited from the Affiliated Hospital of North Sichuan Medical College and Nanchong Central Hospital between March 2016 and November 2018. This study was designed as a case-control study with 1:1 frequency matching, in which the parents of cases and controls were interviewed with the same questionnaire according to the gestational age of the child, maternal age during pregnancy and the same maternal race/ethnicity. Then, 322 matched case-control pairs were analysed by SPSS 22. Thirty-one suspicious factors were entered into the binary logistic regression analysis after univariate regression analysis of 55 factors (alpha = 0.05). The analysis results showed that 7 factors were significantly associated with the occurrence of CHD. Thus, augmenting maternal mental healthcare, improving the quality of drinking water, obtaining adequate nutrition, maintaining a healthy physical condition during pregnancy, enhancing parents' level of knowledge and maintaining a healthy lifestyle may lower the occurrence of cHD. Resultscomposition of the object of study. The 322 matched case-control pairs were analysed by SPSS from the original cases in the study population (Tables 1 and 2). Among the 322 analysed cases, 182 (56.5%) were males and 140 (43.5%) were females. There were 163 (50.6%) males and 159 (49.4%) females in the matched control group. There was no significant difference in the gender distribution between the two groups (χ 2 = 2.254, P = 0.133) ( Table 3). The distribution of children in different age groups in the two groups is shown in Table 3, and the difference was not statistically significant (χ 2 = 4.826, P = 0.566). Scientific RepoRtS |(2020) 10:3905 | https://doi.The exclusion criteria were as follows: (1) Children with congenital malformations of other systems and other family genetic diseases; (2) children with myocarditis, cardiomyopathy and other cardiovascular diseases; (3) parents with conscious disorder, mental disorder, communication disorder, or poor memory of events during pregnancy; and (4) parents of children who did not agree to participate in the survey.Selection of the control group. With respect to the admission criteria, controls without any congenital malformations were randomly selected among children who were undergoing physical disease treatment.The exclusion criteria were as follows: (1) Children with other inherited familial diseases;(2) children with cardiovascular diseases such as myocarditis and cardiomyopathy; (3) parents with conscious disorder, mental disorder, communication disorder, or poor memory of events during pregnancy; and (4) parents who did not agree to participate in the survey. Scientific RepoRtS |(2020) 10:3905 | https...

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Non-inheritable risk factors during pregnancy for congenital heart defects in offspring: A matched case-control study

Cited by 18 publications

References 39 publications

Environmental Risk Factors for Congenital Heart Disease

Environmental Risk Factors for Congenital Heart Disease

Associations of maternal upper respiratory tract infection/influenza during early pregnancy with congenital heart disease in offspring: evidence from a case-control study and meta-analysis

Parental non-hereditary teratogenic exposure factors on the occurrence of congenital heart disease in the offspring in the northeastern Sichuan, China

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