Non-Hodgkin's lymphomas in leukemic phase: Clinicopathologic correlations

Come, Steven E.; Jaffe, Elaine S.; Andersen, Judith C.; Mann, Risa B.; Johnson, Bonnie; DeVita, Vincent T.; Young, Robert C.

doi:10.1016/0002-9343(80)90416-7

Cited by 65 publications

(22 citation statements)

References 23 publications

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“…Lymphoma cells have been detected on peripheral blood smear in 8-20% of patients with NHL (Come et al, 1980;Dick et al, 1974;Foucar et al, 1982;McKenna et al, 1975;Morra et al, 1985). With (Garrett et al, 1979;Johnson et al, 1985: igler et al.…”

Section: Discussionmentioning

confidence: 99%

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Circulating lymphoma cells in patients with B & T non-Hodgkin's lymphoma detected by immunoglobulin and T-cell receptor gene rearrangement

Brada

Mizutani²,

Molgaard³

et al. 1987

Br J Cancer

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We studied peripheral blood mononuclear cells from 50 patients with active B- and T-cell non-Hodgkin's lymphoma by DNA hybridisation. Nineteen patients (38%) had circulating clones of cells detected by immunoglobulin gene rearrangement (17 patients) or T-cell receptor gene rearrangement (2 patients) with JH and J beta 2 probes. Lymphoma tissue and peripheral blood were studied simultaneously in 22 patients, 9 of which had a circulating clone of cells in peripheral blood. In 7 patients the gene rearrangement in lymphoma tissue and peripheral blood mononuclear cells was identical. However, in 2 patients both heavy chain and light chain gene rearrangements were different in tissue and peripheral blood. The incidence of peripheral blood involvement was commonest in advanced CSIII & IV disease (54%) compared to CSI & II disease (18%) (P less than 0.05), and in low grade (45%) compared to intermediate and high grade lymphoma (31%) (difference not statistically significant). Only 4 patients had definite lymphoma cells seen on peripheral blood smear. The presence of circulating lymphoma cells correlated with conventional assessment of bone marrow involvement although circulating clones were detected in 30% (12/40) of patients with apparently normal bone marrow. Images Figure 1 Figure 2 Figure 3

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Section: Discussionmentioning

confidence: 99%

“…Lymphoma cells have been detected in peripheral blood by routine morphological examination of the blood smear (Come et al, 1980;Dick et al, 1974;Foucar et al, 1982;Garrett et al, 1979;McKenna et al, 1975). Their presence in B-cell lymphoma has also been implied with k and .…”

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confidence: 99%

Circulating lymphoma cells in patients with B & T non-Hodgkin's lymphoma detected by immunoglobulin and T-cell receptor gene rearrangement

Brada

Mizutani²,

Molgaard³

et al. 1987

Br J Cancer

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“…After transformation, FL has a variable histology and phenotype, with diffuse large B-cell lymphoma (DLBCL) being most common, followed by Burkitt-like lymphoma (Aventin et al, 1990;Yano et al, 1992) and blastic morphology (Come et al, 1980;Weiss and Warnke, 1985). Clonality studies strongly suggest that the majority of DLBCLs arising in FL are clonally related to the initial lymphoma (Matolcsy et al, 1999;Traweek et al, 1993;Zelenetz et al, 1991).…”

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confidence: 99%

Gene Expression Profile of Serial Samples of Transformed B-Cell Lymphomas

Vos

Hofmann

Grogan

et al. 2003

Laboratory Investigation

106

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SUMMARY:Follicular lymphoma (FL) is characterized by a continuous rate of relapse and transformation to a high-grade lymphoma, usually diffuse large B-cell lymphoma (DLBCL), associated with a dismal prognosis and a poor response to conventional chemotherapy. The progression of indolent to aggressive FL is accompanied by the successive accumulation of recurrent chromosomal defects, but the resultant alterations of gene expression are largely unknown. To expand the understanding of the pathogenesis of FL transformation, we initially performed oligonucleotide microarray analyses using Affymetrix HuFL chips on five cases with matched snap-frozen lymph nodes before and after transformation. Expression data were analyzed using the Affymetrix Microarray Suite 4.0 and Genespring 4.0. Thirty-six genes with increased expression and 66 genes with decreased expression associated with transformation were identified and functionally classified. The expression of differentially expressed genes was confirmed by real-time quantitative RT-PCR (QRT-PCR) using a total of seven matched pairs and an additional five FL and five unrelated DLBCL. In addition, selected genes were further analyzed by QRT-PCR or immunohistochemistry using a large, unrelated series of FL (grades 1 to 3) as well as transformed and de novo DLBCL (total of 51 samples). The microarray results correlated with the protein expression data obtained from samples at the time of initial diagnosis and transformation. Furthermore, the expression of 25 candidate genes was evaluated by QRT-PCR with a 78% confirmation rate. Some of the identified genes, such as nucleobindin, interferon regulatory factor 4, and tissue inhibitor of metalloproteinases 1, are already known to be associated with high-grade non-Hodgkin's lymphoma. Novel candidate genes with confirmed increased and decreased expression in transformed DLBCL include ABL2 and NEK2, and PDCD1 and VDUP1, respectively. In summary, this study shows that transformation of FL to DLBCL is associated with a distinct set of differentially expressed genes of potential functional importance. (Lab Invest 2003, 83:271-285).

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“…They can be seen by simple morphological examination of peripheral blood smear in 8-20% of patients (Come et al, 1980;Dick et al, 1974;Foucar et al, 1982;McKenna et al, 1975;Morra et al, 1985). The clonal nature of lymphoma allows for the detection of lymphoma cells by techniques relying on clonality.…”

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confidence: 99%