Non-Hodgkin's lymphoma of the tonsil .A clinicopathologic study of 65 cases

Barton, Joel H.; Osborne, Barbara M.; Butler, James J.; Meoz, Raul T.; Kong, Joseph S.; Fuller, Lillian M.; Sullivan, Jane A.

doi:10.1002/1097-0142(19840101)53:1<86::aid-cncr2820530116>3.0.co;2-e

Cited by 61 publications

(37 citation statements)

References 35 publications

(2 reference statements)

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“…In our study, Waldeyer's ring N H L had a somewhat higher survival than extranodal and nodal NHL, but the difference was not statistically significant. Some authors have found a better prognosis in stage I than in stage I1 (3)(4)(5)(6)(8)(9)(10) head and neck NHL but this could not be verified in the present study. One reason may be that our patients were distributed over a long time period which might have influenced the staging.…”

Section: Discussioncontrasting

confidence: 95%

Prognostic Factors in Head and Neck Non-Hodgkin's Lymphoma with Special Reference to Serum Lactic Dehydrogenase and Serum Copper

et al. 1990

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Section: Discussioncontrasting

confidence: 95%

Prognostic Factors in Head and Neck Non-Hodgkin's Lymphoma with Special Reference to Serum Lactic Dehydrogenase and Serum Copper

et al. 1990

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“…Due to frequent relapses, both in nodal and extranodal sites, and usually distant from the primary site, only half of WR NHL patients remain disease free, and 0s of W R NHL patients at 10 years is poor. The observed DFS of our patients corresponds well with results from other series on WR NHL patients mainly treated with radiotherapy(24), as does the observation that 50% of patients who are locally treated relapse. (3;…”

mentioning

confidence: 99%

Waldeyer's Ring Lymphomas: A Clinical Study from the Comprehensive Cancer Center West Population Based NHL Registry

Krol

Cessie

Snijder

et al. 2001

Leukemia & Lymphoma

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It is debated whether non-Hodgkin's lymphomas originating in Waldeyer's ring (WR NHL) behave as NHL originating in lymph nodes or share common features with extranodal lymphomas originating in mucosa associated lymphatic tissue (MALT). We analyzed data from a population based NHL registry on patterns of dissemination at diagnosis, response to treatment, patterns of failure and survival of 77 primary Waldeyer's ring Non-Hodgkin's lymphomas (WR NHL) patents. Data of completely staged patients with diffuse large cell lymphomas (DLCL) originating in WR (n=44) were compared with those of patients retrieved from the same registry with DLCL originating in lymph nodes or stomach (the latter as prototype of a lymphoma originating in MALT). Primary WR NHL had favorable risk scores according to the International Prognostic Index (IPI), and responded well to therapy: a complete response (CR) rate of 74% was observed. Disease free survival (DFS) and overall survival (OS) were poor, however (47% and 31% at 10 years, respectively). The comparison of DLCL originating in WR, lymph nodes and stomach revealed that WR and gastric NHL patients shared a restricted pattern of dissemination at diagnosis, in contrast to patients with DLCL originating in lymph nodes. Although not all patients were completely restaged at relapse, analysis of patterns of failure suggested that the gastro-intestinal tract is a preferential site for recurrences, both for WR and gastric DLCL patients. CR rates of WR, nodal and gastric DLCL patients were 77%, 55% and 55% respectively (P=0.03), OS of the three patient subgroups did not differ (33%, 27% and 37% at 10 years). DFS of WR DLCL patients was similar to nodal DLCL patients but inferior to gastric DLCL patients (47%, 48% and 73% at 10 years respectively, P=0.006). After Cox regression analysis the relative relapse risk for patients with WR DLCL when compared to patients with DLCL originating in lymph nodes was 2.01 (C.I. 0.99-4.01, P=0.05), and 3.46 (C.I. 1.32-9.00, P=0.01) when compared to patients with gastric DLCL. The clinical picture of primary WR NHL emerging from this population based study is in agreement with data form hospital based studies. In the comparison of WR DLCL, nodal DLCL and gastric DLCL, the observed patterns of dissemination suggest similarities between WR DLCL and gastric DLCL. The frequent relapses after CR observed for WR DLCL patients, however, indicate that these lymphomas clinically behave as nodal DLCL, and should be treated accordingly.

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“…Tonsil tutulumu gösteren non-Hodgkin lenfomalarda ortalama hasta yaşı 59 olarak bildirilmiştir [4]. Lenfoma tutulumu gösteren vakalarımızda, literatürle uyumlu olacak şekilde ortalama hasta yaşı 55.52 ± 20.66 olarak saptanmıştır.…”

Section: Bulgularunclassified

Retrospective look to tonsillary lesions and the location of malign lesions in distribution

Alabalık

Avcı²,

Türkçü³

et al. 2014

J Clin Exp Invest

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Objective: In this study, we investigate the distribution of malign lesions in all tonsillar lesions and the compatibility with the literature. Methods:The pathology reports and preparations of 1118 patients whose tonsillectomy and tonsil biopsy materials were assessed in Department of Pathology in Dicle University Medical Faculty between January 2006 and September 2013 are examined retrospectively and included to the study. Results:Of 1118 patients, the diagnoses were chronic inflammation in 452 (40.43%), lymphoid hyperplasia in 226 (20.21%), chronic inflammation and lymphoid hyperplasia in 411 (36.76%), cyst in 2 (0.18%), squamous papilloma in 2 (0.18%) and malignancy was observed in 25 (2.24%). Of 25 malign cases, the diagnoses were Bcell non-Hodgkin lymphoma in 19 (76%), epidermoid carcinoma in 4 (16%), plasmacytoma in 1 (4%) and malign melanoma in 1 (4%). Conclusion:Primary tonsillar malignancies constitute 2% of all human malignancies. Epidermoid carcinomas (75%) and lymphomas take the first and second places in frequency respectively. In our study conversely lymphomas account for 76% of all tonsillar malignancies that makes an important portion, while epidermoid carcinomas account for 16% of those. B-cell non-Hodgkin lymphomas constitute the vast majority of lymphomas showing tonsillar involvement. It is reported that the most frequently seen lymphoma type in tonsillar location is diffuse large B-cell lymphoma. Consistent with this information in our study, it is determined that 15 of 19 tonsillar lymphoma cases are diffuse large B-cell lymphoma. J Clin Exp Invest 2014; 5 (4): 577-579 Key words: Tonsil, lymphoma, epidermoid carcinoma Sonuç: Primer tonsil maligniteleri tüm insan malignitelerinin %2'sini oluşturur. İlk sırada yassı hücreli karsinomlar (%75), ikinci sırada lenfomalar yer alır. Çalışmamızda bunun aksine lenfomalar malignitelerin %76 gibi önemli bir kısmını oluştururken yassı hücreli karsinomlar tüm tonsil malignitelerinin ancak %16'lık kısmını meydana getirmiş-tir. Tonsiller tutulum gösteren lenfomaların büyük çoğun-luğunu B hücreli non-Hodgkin lenfomalar, oluşturmakta-dır. Tonsil lojunda en sık görülen lenfoma tipinin diffüz büyük B hücreli lenfomalar olduğu bildirilmektedir. Bizim çalışmamızda da buna uyumlu olarak, toplam 19 lenfoma vakamızdan 15'inin diffüz büyük B hücreli lenfoma olduğunu görülmektedir.Anahtar kelimeler: Tonsil, lenfoma, yassı hücreli karsinom

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Non-Hodgkin's lymphoma of the tonsil .A clinicopathologic study of 65 cases

Cited by 61 publications

References 35 publications

Prognostic Factors in Head and Neck Non-Hodgkin's Lymphoma with Special Reference to Serum Lactic Dehydrogenase and Serum Copper

Prognostic Factors in Head and Neck Non-Hodgkin's Lymphoma with Special Reference to Serum Lactic Dehydrogenase and Serum Copper

Waldeyer's Ring Lymphomas: A Clinical Study from the Comprehensive Cancer Center West Population Based NHL Registry

Retrospective look to tonsillary lesions and the location of malign lesions in distribution

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