Non-Hodgkin's Lymphoma in 90 Homosexual Men

Abstract

We describe the histologic and clinical features of non-Hodgkin's lymphoma diagnosed between January 1980 and December 1983 in 90 homosexual men from San Francisco, Los Angeles, Houston, and New York. The median age was 37 years, with an age distribution identical to that for cases of AIDS reported to the Centers for Disease Control. Sixty-two per cent of the patients had high-grade (aggressive) subtypes of lymphoma, 29 per cent had subtypes of intermediate grade, and 7 per cent had low-grade subtypes. Histologic subtypes and malignant cell phenotypes were consistent with a B-cell origin. All but two men had extranodal lymphoma: central-nervous-system, bone-marrow, bowel, and mucocutaneous sites were most commonly involved. Thirty-five of 66 evaluable men (53 per cent) had complete responses to combination chemotherapy or radiotherapy or both, and thus far, 19 (54 per cent) of them have had a relapse. Mortality and morbidity were closely related to prodromal manifestations; death or illness have occurred in 19 (91 per cent) of the 21 men who presented with AIDS, in 26 (79 per cent) of the 33 who presented with generalized lymphadenopathy, and in 5 (42 per cent) of the 12 who had no prodromal manifestations. Mortality rates analyzed according to histologic grade were higher than currently reported rates in other patient populations. Kaposi's sarcoma or severe opportunistic infections characteristic of AIDS developed in 14 of 33 men (42 per cent) who presented with generalized lymphadenopathy and in 3 of 12 (33 per cent) without prodromal manifestations. We conclude that non-Hodgkin's lymphoma in members of an AIDS risk group is a serious manifestation of AIDS and the AIDS-related complex.

Cutaneous Plasmablastic Lymphoma in an HIV-Positive Male: An Unrecognized Cutaneous Manifestation

“…at least 60 times greater than that expected in the general population [10, 11]. In 1985, the Centers for Disease Control included high-grade B-cell lymphoma as an AIDS-defining illness [12]. The introduction of highly active antiretroviral therapy resulted in a substantial relative risk reduction for Kaposi’s sarcoma, primary central nervous system lymphoma and other AIDS-defining conditions but showed a lesser decline for AIDS-related NHL [13].…”

The Impact of Human Immunodeficiency Virus Infection (HIV) on Lymphoma in South Africa

“…Lymphomas are encountered with increased frequency in people living with HIV/AIDS (PWHA) [3]. In the post HAART (highly active anti-retroviral therapy) era, non-Hodgkin lymphoma (NHL) is the most common malignancy in PWHA, superseding Kaposi's sarcoma.…”

“…This is particularly true in resource-limited settings, such as sub-Saharan Africa, where there is a noticeable increase in NHL incidence [6]- [9]. HIV-NHL are typically highgrade, B-cell lymphomas, such as diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma [3] [9] [10]. Indolent lymphomas tend to be more sporadic, and according to the AIDS Lymphoma Registry, account for <3% of all NHL occurring in HIV seropositive patients [11].…”

“…High grade (aggressive), B-cell NHL is the classical haematological malignancy that complicates HIV [3]. However, in the last decade it has become apparent that Hodgkin lymphoma (HL) is an emerging HIV-associated malignancy [4] [5].…”

Mielite transversa como manifestação clínica inicial de linfoma não Hodgkin disseminado e mielopatia vacuolar associada ao HIV: relato de caso

“…Uma característica marcante destas neoplasias associadas à AIDS (LNHD-AIDS) é a disseminação extranodal da doença no diagnóstico inicial (84% segundo Levine 15 e 75 a 95% segundo Kaplan"). A freqüência de envolvimento do SNC varia de 15,4% a 43%, sendo o linfoma encefálico o achado mais comum 12 ' 5 ' 33 . O comprometimento epidural varia de 3,5% a 8,3% 12,19 Apenas 15% dos pacientes com este tipo de linfoma foram diagnosticados previamente à síndrome de compressão espinhal, numa série de pacientes não aidéticos 9 .…”