Non-Hodgkin's lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection

Duberg, Ann‐Sofi; Nordström, Marie; Törner, Anna; Reichard, Olle; Strauß, Reinhild; Janzon, Ragnhild; Bäck, Erik; Ekdahl, Karl

doi:10.1002/hep.20608

Cited by 122 publications

(116 citation statements)

References 33 publications

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“…555 Similarly, other studies have not reported increased NHL risk in association with HCV infection, [555][556][557][558][559][560][561] whereas numerous other studies have reported positive associations. 561,[562][563][564][565][566][567][568][569][570][571][572][573][574][575][576][577][578][579] Gisbert et al 580 conducted a meta-analysis of studies that compared the prevalence of HCV infection in B-cell lymphoma cases with that in controls. An excess risk (meta-OR 5 10.82, 95% CI, 7.34-15.94) of NHL was reported across 10 studies that provided odds ratios.…”

Section: Interactions With Environment and Lifestyle Factorsmentioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

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Section: Interactions With Environment and Lifestyle Factorsmentioning

confidence: 99%

The non-Hodgkin lymphomas: A review of the epidemiologic literature

et al. 2007

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“…However, a study in Denmark [27], which is an area of low HCV prevalence, has shown association of HCV and lymphoma. In a Swedish study, Duberg et al [28] reported the incidence of several malignancies in a nationwide cohort of HCV-infected persons. This study showed significantly increased risk of NHL and multiple myeloma in HCV-infected patients.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C virus infection among patients with non-Hodgkin’s lymphoma in northern India

et al. 2011

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Background and aim Hepatitis C virus (HCV) has been postulated to be an etiological agent for lymphoid malignancies. Whereas a high prevalence of HCV infection in non-Hodgkin's lymphoma (NHL) patients has been shown to exist in many geographical areas of high HCV prevalence, studies from other parts have not established any form of association. In India, there is a scarcity of data to show either a positive or a negative association between NHL and HCV infection. Therefore, we determined the prevalence of HCV infection in patients with NHL. Methods A total of 228 subjects were included, out of which, the number of newly diagnosed consecutive patients with lymphoproliferative disorders (NHL and CLL) were 57 [mean age, 48.7 years (range: 18-80)] and the control group consisted of 171 subjects [mean age, 48.6 years (range: 18-80)]. We used third generation enzyme immunoassay to detect HCV antibodies. HCV RNA was detected by nested RT-PCR. Results Among the 57 patients of NHL, 44 (77.2%) had high-grade disease (diffuse large B cell), 6 (10.5%) intermediate-grade (follicular lymphoma), and 7 (12.3%) lowgrade (small lymphocytic); 26 patients had B symptoms at diagnosis. None of the patient tested positive for antibody to hepatitis C virus (anti-HCV) while 1 patient (1.75%) tested positive for HCV RNA. Among the age-and sexmatched controls, 2 (1.17%) subjects tested positive for anti-HCV; both were also positive for HCV RNA. Conclusions HCV infection is unlikely to be associated with lymphoproliferative disorders in northern India and does not play a major role in the pathogenesis of lymphoproliferative disorders.

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“…All patients developed a high-grade "B" phenotype NHL, as in the presented patient. Other study 3 evaluated the association between HCV infection and different malignancies in a Swedish cohort of 27,150 HCV-infected persons during 1990 through 2000. This study demonstrated a statistically significant increased risk of NHL and multiple myeloma, especially in those patients with more than 15 years of HCV infection.…”

Section: Discussionmentioning

confidence: 99%

Primary liver AIDS-related lympoma

Villafañe

Trione

Corti

et al. 2006

Rev. Inst. Med. trop. S. Paulo

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SUMMARYNon-Hodgkin's lymphomas (NHL) are the second most frequent malignancies in AIDS patients. The majority of NHL associated with AIDS involves extranodal sites, especially the digestive tract and the central nervous system. Primary liver lymphoma (PLL) is an uncommon neoplasm among these patients. Ultrasonography and computed tomography scans may be helpful in the diagnosis of focal hepatic lymphoma. Image-guided fine-needle biopsy with histopathology of the liver lesions is the gold standard for the diagnosis of hepatic lymphoma. We report a case of PLL as the initial manifestation of AIDS in a patient without any previous infection by hepatitis C or B virus, presented as multiple and large hepatic masses.

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Non-Hodgkin's lymphoma and other nonhepatic malignancies in Swedish patients with hepatitis C virus infection

Cited by 122 publications

References 33 publications

The non-Hodgkin lymphomas: A review of the epidemiologic literature

The non-Hodgkin lymphomas: A review of the epidemiologic literature

Hepatitis C virus infection among patients with non-Hodgkin’s lymphoma in northern India

Primary liver AIDS-related lympoma

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