“…The impact of agricultural practices on nitrate contamination of surface and underground waters has been studied in many parts of the world (Patni et Water with nitrate levels above 10 mg L − 1 can cause health problems to humans, which include methemoglobinemia or the "Blue Baby Syndrome" (Bryson et al, 1989;Sasson, 1993), different types of cancer (Mirvish et al, 1987;Weisemburger, 1991;Ward et al, 2000;Weyer et al, 2001;Gulis et al, 2002), hyperthyroidism (Seffner, 1995), an increase of insulin-dependent people (Kostraba et al, 1992), deformation of children's central nervous system (Scragg et al, 1982;Arbuckle et al, 1988), and de ciencies in babies' neural tubes (Croen et al, 2001). Considering all studies to date, the strongest evidence for a relationship between drinking water nitrate ingestion and adverse health outcomes (besides methemoglobinemia) is for colorectal cancer, thyroid disease, and neural tube defects.…”