2000
DOI: 10.1136/jech.54.10.772a
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Non-Hodgkin's lymphoma and nitrate in drinking water

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Cited by 6 publications
(4 citation statements)
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References 7 publications
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“…We applied the parameterized multiple logistic regression models to predict the probability of exceeding two specified nitrate concentrations. We used a threshold of 10 mg nitrate-NL −1 (10 ppm) to represent the maximum contaminant standard set by the US Environmental Protection Agency (US EPA 2011) and a threshold of 4 mg nitrate-NL −1 (4 ppm) because exposure at or near to this level has been linked to birth defects and increased risks of some cancers (Weyer et al 2008, Ward et al 2000, Brender et al 2013. We tested the fully-specified model for evidence of spatial autocorrelation by plotting model residuals and estimating global Moran's I statistics in ArcGIS, but found no evidence for significant spatial autocorrelation (z = 1.51, p = 0.12).…”
Section: Model Form and Estimationmentioning
confidence: 99%
See 1 more Smart Citation
“…We applied the parameterized multiple logistic regression models to predict the probability of exceeding two specified nitrate concentrations. We used a threshold of 10 mg nitrate-NL −1 (10 ppm) to represent the maximum contaminant standard set by the US Environmental Protection Agency (US EPA 2011) and a threshold of 4 mg nitrate-NL −1 (4 ppm) because exposure at or near to this level has been linked to birth defects and increased risks of some cancers (Weyer et al 2008, Ward et al 2000, Brender et al 2013. We tested the fully-specified model for evidence of spatial autocorrelation by plotting model residuals and estimating global Moran's I statistics in ArcGIS, but found no evidence for significant spatial autocorrelation (z = 1.51, p = 0.12).…”
Section: Model Form and Estimationmentioning
confidence: 99%
“…The US Environmental Protection Agency has set a maximum contaminant level (MCL) of 10 mg L −1 (10 ppm) nitrate-nitrogen due to concerns over the link between consumption of high levels of nitrate and methemoglobinemia or Blue Baby Syndrome (Spalding and Exner 1993). Exposure to levels of nitrate below the federal drinking water standard (2.5 to 5.5 mg L −1 nitrate-N) has also been associated with increased risks of some cancers, birth defects, and spontaneous abortions (Weyer et al 2008, Ward et al 2000, Ward et al 1996, Brender et al 2013.…”
Section: Introductionmentioning
confidence: 99%
“…Vale observar que um dos parâmetros mais citados pelos laboratórios para garantir a confiabilidade dos resultados de medição foi o nitrato. Sua determinação na água indica a contaminação antropogênica do meio ambiente e tem causado grande interesse na saúde pública pelos estudos epidemiológicos, com evidências da incidência de meta-hemoglobinemia e de vários tipos de câncer associados à presença de nitrato na água de consumo humano [19][20][21][22][23] . Isso demonstra a importância do monitoramento da qualidade da água consumida pela população e, mais ainda, a necessidade de resultados representativos (com rastreabilidade metrológica) para que ações de vigilância tenham a segurança requerida.…”
Section: Resultsunclassified
“…The impact of agricultural practices on nitrate contamination of surface and underground waters has been studied in many parts of the world (Patni et Water with nitrate levels above 10 mg L − 1 can cause health problems to humans, which include methemoglobinemia or the "Blue Baby Syndrome" (Bryson et al, 1989;Sasson, 1993), different types of cancer (Mirvish et al, 1987;Weisemburger, 1991;Ward et al, 2000;Weyer et al, 2001;Gulis et al, 2002), hyperthyroidism (Seffner, 1995), an increase of insulin-dependent people (Kostraba et al, 1992), deformation of children's central nervous system (Scragg et al, 1982;Arbuckle et al, 1988), and de ciencies in babies' neural tubes (Croen et al, 2001). Considering all studies to date, the strongest evidence for a relationship between drinking water nitrate ingestion and adverse health outcomes (besides methemoglobinemia) is for colorectal cancer, thyroid disease, and neural tube defects.…”
Section: Introductionmentioning
confidence: 99%