Non-Hodgkin Lymphoma Causing Hypopituitarism Can Imaging Help Diagnosis and Management?

Khan, Uzma; Borg, Anton; Beltechi, Radu; Mehta, Hiten; Robbins, Timothy; Randeva, Harpal S.; Machenahalli, Pratibha

doi:10.12890/2021_002980

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…Primary pituitary lymphomas are very rare, with about 40 cases reported [ 52 ]. Secondary pituitary lymphomas are associated with metastasis or invasion of systemic lymphoma and are also rare accounting for less than 0.5% of all reported pituitary metastases [ 53 ]. CDI/AVP-D may occur in approximately 40% of pituitary lymphomas [ 54 ].…”

Section: Lymphomamentioning

confidence: 99%

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Tsukamoto¹,

Miki²

2023

Jpn J Radiol

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Many types of tumors can develop in the pituitary gland. In the recently revised 5th editions of the World Health Organization (WHO) classifications (2021 WHO Classification of Central Nervous System Tumors and the 2022 WHO Classification of Endocrine and Neuroendocrine Tumors), various changes have been made to the tumors other than pituitary neuroendocrine tumor (PitNET)/pituitary adenoma, as well as PitNET. Adamantinomatous craniopharyngioma and papillary craniopharyngioma are now considered separate tumors in the 5th edition of the WHO classification. Tumors positive for thyroid transcription factor 1, a marker of posterior pituitary cells, are now grouped together in the pituicyte tumor family in the 5th edition of the WHO classification of Endocrine and Neuroendocrine Tumors. Poorly differentiated chordoma is newly listed in the 5th edition of the WHO Classification of Endocrine and Neuroendocrine Tumors. In this paper, we present the latest WHO classification of pituitary tumors (adamantinomatous craniopharyngioma, papillary craniopharyngioma, pituitary blastoma, pituicyte tumor family, tumors of pituitary origin other than those of the pituicyte tumor family, germinoma, meningioma, chordoma, metastatic tumors, lymphoma, and pituitary incidentaloma), review diseases requiring differentiation from tumors (pituitary abscess, hypophysitis, pituitary hyperplasia, Rathke’s cleft cyst, arachnoid cyst, and aneurysm), and discuss diagnoses based on imaging findings.

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Section: Lymphomamentioning

confidence: 99%

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Tsukamoto¹,

Miki²

2023

Jpn J Radiol

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“…Hypofunction caused by similar related diseases has been reported, and supplementation with the appropriate hormones is sufficient. 14 , 15 …”

Section: Discussionmentioning

confidence: 99%

“…Hypofunction caused by similar related diseases has been reported, and supplementation with the appropriate hormones is sufficient. 14,15 Due to the high recurrence rate and systemic invasive tumor biology of these hematological malignancies, close follow-up is warranted. In this case, it has been more than 6 months since the operation, and the patient is still available for follow-up.…”

Section: Discussionmentioning

confidence: 99%

Chronic lymphocytic leukemia/small lymphocytic lymphoma arising in the pituitary gland: illustrative case

Zhou,

Zhang,

Jia

et al. 2024

Journal of Neurosurgery: Case Lessons

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BACKGROUND The authors describe a 60-year-old female who underwent a correlative examination for an accidental scalp injury, revealing a sellar mass, which was surgically excised and pathologically confirmed to be a non-Hodgkin’s small B-cell lymphoma. These findings in combination with the immunophenotype led to a final diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma. Previous studies have shown that hematological solid tumors occurring in the pituitary gland are extremely rare, and there are only approximately three other cases of living patients with similarities to this case, all of which had ambiguous expression of subsequent hematological treatment. OBSERVATIONS In this case, the authors used an endoscopic approach to completely excise the tumor. Follow-up of the patient was continued after surgery, and the patient is currently receiving standardized treatment with zanubrutinib. LESSONS This patient did not have any previous history of tumor, had a good postoperative recovery with a normal quality of life, and still receives hormone replacement and zanubrutinib on a standardized basis. This is a complete case that has not been previously reported and reveals the diagnostic and therapeutic process of rare diseases in the sellar area.

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“…Pituitary lymphomas will act in situ as a mass formation, differently from secretory hypophyseal tumors of endocrine nature, and will therefore present mainly with visual field deficits, headache and oculomotor nerve palsies. However, hypopituitarism has been reported as well [8], [9].…”

Section: Introductionmentioning

confidence: 99%

Non-Hodgkin B-cell Lymphoma Presenting as a Pituitary Mass

Seferi

Ikonomi

Lilamani

et al. 2023

Open Access Maced J Med Sci

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INTRODUCTION: The authors describe the case of a pituitary mass considered from the radiological point of view as a non-secretory adenoma. CASE REPORT: The patient, a 31-year-old male, presented with an intense headache, non-responsive to antalgics, right eye Mydriasis, and semiptosis. An endoscopic transnasal surgery caused important but temporary relief to the patient, who some days later complained of tumefactions in both axillar regions. Pathological diagnosis was of a non-Hodgkin B-cell lymphoma. CONCLUSIONS: Although pituitary involvement is rare in the case of systemic lymphomas, and even rarer among primary central nervous system malignancies, this possibility must become part of differential diagnosis when approaching pituitary masses.

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Non-Hodgkin Lymphoma Causing Hypopituitarism Can Imaging Help Diagnosis and Management?

Cited by 4 publications

References 6 publications

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Imaging of pituitary tumors: an update with the 5th WHO Classifications—part 2. Neoplasms other than PitNET and tumor-mimicking lesions

Chronic lymphocytic leukemia/small lymphocytic lymphoma arising in the pituitary gland: illustrative case

Non-Hodgkin B-cell Lymphoma Presenting as a Pituitary Mass

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