Non-Hodgkin B-cell Lymphoma Presenting as a Pituitary Mass

Seferi, Arsen; Ikonomi, Majlinda; Lilamani, Ejona; Vyshka, Gentian

doi:10.3889/oamjms.2023.11027

Cited by 1 publication

(2 citation statements)

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“…In the literature, only 57 PPL cases have been reported, and 34 of these cases had ophthalmological symptoms. Only 18 of these reported cases included pre-and postoperative ophthalmological examination (Table 1) [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. This is the first study to investigate and review treatment responses to the ophthalmological symptoms of PPL patients.…”

Section: Discussionmentioning

confidence: 99%

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Treatment Response to Acute Total Ophthalmoplegia in Primary Pituitary Lymphoma: A Case Report and Review of the Literature

Uygur,

Karataş,

Arslan

et al. 2024

Cureus

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Primary pituitary lymphoma (PPL) is an extremely rare localized lymphoma without systemic involvement. The most common clinical presentations of PPL are hypopituitarism, headaches, and ophthalmoplegia. Diagnosing PPL without a biopsy is almost impossible. There is no study that has specifically investigated and reviewed treatment responses to the ophthalmological symptoms of PPL patients. Herein, we present a 66-year-old female patient who had acute-onset total ophthalmoplegia and headache as admission symptoms, which was diagnosed as PPL after subtotal resection. In the present study, we discussed the response of ophthalmological symptoms to treatment with a review of the literature. Only 18 reported cases had postoperative ophthalmological examination, and in 94.4% of these cases, ophthalmoplegia resolves after surgery and chemotherapy. The complete resection rate of the PPL in the literature was found to be as low as 12.3% in this region because of the hard and adhesive nature of the tumor. Our review unveiled that complete recovery of ophthalmoplegia can be achieved even in the late phase of the symptoms. In the present case, ophthalmoplegia resolved completely following subtotal resection and rituximab, high-dose methotrexate, and cytarabine treatment.

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Section: Discussionmentioning

confidence: 99%

“…Primary pituitary lymphoma (PPL) is a localized lymphoma in the pituitary gland, which lacks systemic involvement [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. It is an extremely rare tumor, with only 57 reported cases in English literature to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%