Non-Heart-Beating Donor Heart Transplantation: Breaking the Taboo

Fatullayev, Javid; Samak, Mostafa; Sabashnikov, Anton; Weymann, Alexander; Mohite, Prashant N.; Garcia-Saez, Diana; Patil, Nikhil P.; Dohmen, Pascal M.; Popov, Aron‐Frederik; Simón, A.; Zeriouh, Mohamed

doi:10.12659/msmbr.894985

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Deflation starts before aortic valve opening and continues over the first period of systole. Inflation volume depends on the cuff size used, with approximately 20 to 30 ml of blood volume displaced per beat [ 3 ]. Based on the hemodynamics of counterpulsation therapy, the C-Pulse System reduces left ventricular afterload and increases diastolic coronary blood flow [ 6 , 7 ].…”

Section: Methodsmentioning

confidence: 99%

Preliminary Results From the C-Pulse® OPTIONS HF European Multicenter Post-Market Study

Schulz

Krabatsch

Schmitto

et al. 2016

Med Sci Monit Basic Res

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BackgroundThe C-Pulse® System is an extra-aortic balloon counterpulsation device. It is used to treat patients with heart failure disease in NYHA functional class III or ambulatory class IV.Material/MethodsWe present preliminary site-reported 6-month data from 3 centers in Germany as part of the prospective observational post-market OPTIONS HF study.ResultsBetween May 2013 and March 2014, the C-Pulse System was implanted in 8 patients (7 male) with a mean age of 61.6±9.3 years. Four had ischemic and 4 had non-ischemic cardiomyopathy. No stroke, myocardial infarction, major bleeding, or major infection due to the device were reported. One patient developed non-device-related refractory tachycardia with worsening heart failure 12 h after surgery and underwent left ventricular assist device implantation. Within 6 months of observation, functional status improved from NYHA III to II in 5 patients, and 2 remained in NYHA III. Mean left ventricular ejection fraction increased from 24.3±7.9% to 44.5±4.5% (p<0.0001). Mean Kansas City Cardiomyopathy Questionnaire overall score improved from 28.6±19.1 to 59.1±22.5 (p=0.0183). Six-minute walk test was performed in 6 out of 7 patients at follow-up. The mean distance improved from 252.0±85.1 m to 279.2±87.5 m (p>0.05). One patient was weaned off the device after 6 months of support.ConclusionsThe C-Pulse System provides a therapeutic option for patients with moderate-to-severe heart failure and seems to improve quality of life and cardiac function over time.

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Section: Methodsmentioning

confidence: 99%

Preliminary Results From the C-Pulse® OPTIONS HF European Multicenter Post-Market Study

Schulz

Krabatsch

Schmitto

et al. 2016

Med Sci Monit Basic Res

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“…This so called "bridge to transplant" approach lasts two years on average; therefore, heart transplantation is currently the only existing possibility of long-term treatment for endstage patients. Unfortunately, this approach has a high impact on health costs, and is limited by the low number of donors [5].…”

Section: Introductionmentioning

confidence: 99%

iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases

Germena

Hinkel

2021

JPM

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Cardiovascular diseases are the leading cause of mortality worldwide. Understanding the mechanisms at the basis of these diseases is necessary in order to generate therapeutic approaches. Recently, cardiac tissue engineering and induced pluripotent stem cell (iPSC) reprogramming has led to a skyrocketing number of publications describing cardiovascular regeneration as a promising option for cardiovascular disease treatment. Generation of artificial tissue and organoids derived from induced pluripotent stem cells is in the pipeline for regenerative medicine. The present review summarizes the multiple approaches of heart regeneration with a special focus on iPSC application. In particular, we describe the strength of iPSCs as a tool to study the molecular mechanisms driving cardiovascular pathologies, as well as their potential in drug discovery. Moreover, we will describe some insights into novel discoveries of how stem-cell-secreted biomolecules, such as exosomes, could affect cardiac regeneration, and how the fine tuning of the immune system could be a revolutionary tool in the modulation of heart regeneration.

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“…Excess accumulation of wastes can upset internal balances that in turn cause further damage to the kidneys and other organs. Renal failure can also be caused by extra-renal factors such as heart failure, urinary tract obstruction, and urinary reflux [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Co-Expression Analysis of Blood Cell Genome Expression to Preliminary Investigation of Regulatory Mechanisms in Uremia

Liu

2017

Med Sci Monit

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BackgroundUremia involves a series of clinical manifestations and is a common syndrome that occurs in nearly all end-stage kidney diseases. However, the exact genetic and/or molecular mechanisms that underlie uremia remain poorly understood.Material/MethodsIn this case-control study, we analyzed whole-genome microarray of 75 uremia patients and 20 healthy controls to investigate changes in gene expression and cellular mechanisms relevant to uremia. Gene co-expression network analysis was performed to construct co-expression networks using differentially expressed genes (DEGs) in uremia. We then determined hub models of co-expressed gene networks by MCODE, and we used miRNA enrichment analysis to detect key miRNAs in each hub module.ResultsWe found nine co-expressed hub modules implicated in uremia. These modules were enriched in specific biological functions, including “proteolysis”, “membrane-enclosed lumen”, and “apoptosis”. Finally, miRNA enrichment analysis to detect key miRNAs in each hub module found 15 miRNAs that were specifically targeted to uremia-related hub modules. Of these, miRNA-21-3p and miRNA-210-3p have been identified in other studies as being important for uremia.ConclusionsIn summary, our study connected biological functions, genes, and miRNAs that underpin the network modules that can be used to elucidate the molecular mechanisms involved in uremia.

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Non-Heart-Beating Donor Heart Transplantation: Breaking the Taboo

Cited by 7 publications

References 23 publications

Preliminary Results From the C-Pulse® OPTIONS HF European Multicenter Post-Market Study

Preliminary Results From the C-Pulse® OPTIONS HF European Multicenter Post-Market Study

iPSCs and Exosomes: Partners in Crime Fighting Cardiovascular Diseases

Co-Expression Analysis of Blood Cell Genome Expression to Preliminary Investigation of Regulatory Mechanisms in Uremia

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