Handbook on Hyperbaric Medicine
DOI: 10.1007/1-4020-4448-8_20
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Non-Healing Wounds

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Cited by 98 publications
(81 citation statements)
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“…Healing is the end result of a complex event consisting of homeostasis, inflammation, differentiation, proliferation and migration of mesenchymal cell to the wound site, proper angiogenesis, prompt re-epithelialization, cross- linking and alignment of collagen (Mathieu et al, 2006). The samples of all groups indicating inflammatory response at day one (D1) may be due to the result of traumatic tissue handling and suture placement (Runk et al, 1999).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Healing is the end result of a complex event consisting of homeostasis, inflammation, differentiation, proliferation and migration of mesenchymal cell to the wound site, proper angiogenesis, prompt re-epithelialization, cross- linking and alignment of collagen (Mathieu et al, 2006). The samples of all groups indicating inflammatory response at day one (D1) may be due to the result of traumatic tissue handling and suture placement (Runk et al, 1999).…”
Section: Resultsmentioning
confidence: 99%
“…The body weight and age of the animal was ranged from (18)(19)(20) Kg and (1-3) years respectively. The goats were kept on open grazing during the day and at night in a closed stall with concrete floor.…”
Section: Methodsmentioning
confidence: 99%
“…In addition to basal keratinocyte proliferation and migration at the wound site, optimal epidermal healing relies on appropriate inflammation and proper synthesis, cross-linking, and alignment of extracellular matrix proteins to provide strength to the healing tissue (Gosain and DiPietro, 2004;Mathieu et al, 2006). Besides, given CD98hc role in regulating integrins, we also performed immunostaining for integrins.…”
Section: Cd98hc Is Required For Rapid and Efficient Repopulation Of Wmentioning
confidence: 99%
“…Interruptions, aberrancies, or prolongation in the process can lead to delayed wound healing or a nonhealing chronic wound. In adult humans, optimal wound healing involves the following the events: (1) rapid hemostasis; (2) appropriate inflammation; (3) mesenchymal cell differentiation, proliferation, and migration to the wound site; (4) suitable angiogenesis; (5) prompt re-epithelialization (re-growth of epithelial tissue over the wound surface); and (6) proper synthesis, cross-linking, and alignment of collagen to provide strength to the healing tissue (2,3) .…”
Section: Introductionmentioning
confidence: 99%