Non-Healing Wounds

Mathieu, Daniel; Linke, Jean-Christophe; Wattel, F

doi:10.1007/1-4020-4448-8_20

Cited by 98 publications

(81 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Healing is the end result of a complex event consisting of homeostasis, inflammation, differentiation, proliferation and migration of mesenchymal cell to the wound site, proper angiogenesis, prompt re-epithelialization, cross- linking and alignment of collagen (Mathieu et al, 2006). The samples of all groups indicating inflammatory response at day one (D1) may be due to the result of traumatic tissue handling and suture placement (Runk et al, 1999).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

Paul

Rahman²,

Mahmud

et al. 2017

J Adv Vet Anim Res

View full text Add to dashboard Cite

Objective: This experiment was conducted to evaluate the therapeutic potency of marigold flower (Calendula officinalis) and turmeric (Curcuma longa) rhizome paste in wound healing. Materials and methods: Thirty six aseptic surgical wounds were tooled in six non-pregnant black Bengal goats dividing them in 3 groups. Month long information and follow-up examinations along with complications such as edema, wound dehiscence, suture abscess, exudation etc. were studied. Wound healing was assessed by observing some morphological characters as well as histopathological changes of the wounded area. Results: Results revealed that negligible elevation of suture line (1.17±0.11 mm) and significant (P<0.01) reduction of sutured area were observed in goats of turmeric group at day 3 (D3) and 7 (D7) respectively. Moreover, histologic appearance of wound of the similar group displayed splendid development of keratin layer and collagen fiber than the others from day 3 (D3). However, therapeutic efficacy of marigold flower paste was not up to the mark as turmeric in this experiment. Control group treated with povidone iodine, showed good results but took long time. Conclusion: This study could patronize veterinarians to consider the use of herbal plants specially turmeric as a great wound healer. It will also reduce toxicities created by haphazard use and applications of pharmaceutical products. The findings of this very experiment will not only prevent the skin degradation but also help to maintain the good health status of animals. KEYWORDS CORRESPONDENCE:# Sattwikesh Paul, Department of Surgery & Radiology, FVMAS, BSMRAU, Gazipur-1706. Bangladesh. E-mail: paulsattwik@gmail.com

show abstract

Section: Resultsmentioning

confidence: 99%

“…The body weight and age of the animal was ranged from (18)(19)(20) Kg and (1-3) years respectively. The goats were kept on open grazing during the day and at night in a closed stall with concrete floor.…”

Section: Methodsmentioning

confidence: 99%

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

Paul

Rahman²,

Mahmud

et al. 2017

J Adv Vet Anim Res

View full text Add to dashboard Cite

show abstract

“…In addition to basal keratinocyte proliferation and migration at the wound site, optimal epidermal healing relies on appropriate inflammation and proper synthesis, cross-linking, and alignment of extracellular matrix proteins to provide strength to the healing tissue (Gosain and DiPietro, 2004;Mathieu et al, 2006). Besides, given CD98hc role in regulating integrins, we also performed immunostaining for integrins.…”

Section: Cd98hc Is Required For Rapid and Efficient Repopulation Of Wmentioning

confidence: 99%

CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

Boulter¹,

Estrach²,

Errante³

et al. 2013

J Cell Biol

View full text Add to dashboard Cite

Skin aging is linked to reduced epidermal proliferation and general extracellular matrix atrophy. This involves factors such as the cell adhesion receptors integrins and amino acid transporters. CD98hc (SLC3A2), a heterodimeric amino acid transporter, modulates integrin signaling in vitro. We unravel CD98hc functions in vivo in skin. We report that CD98hc invalidation has no appreciable effect on cell adhesion, clearly showing that CD98hc disruption phenocopies neither CD98hc knockdown in cultured keratinocytes nor epidermal 1 integrin loss in vivo. Instead, we show that CD98hc deletion in murine epidermis results in improper skin homeostasis and epidermal wound healing. These defects resemble aged skin alterations and correlate with reduction of CD98hc expression observed in elderly mice. We also demonstrate that CD98hc absence in vivo induces defects as early as integrin-dependent Src activation. We decipher the molecular mechanisms involved in vivo by revealing a crucial role of the CD98hc/integrins/Rho guanine nucleotide exchange factor (GEF) leukemia-associated RhoGEF (LARG)/RhoA pathway in skin homeostasis. Finally, we demonstrate that the deregulation of RhoA activation in the absence of CD98hc is also a result of impaired CD98hc-dependent amino acid transports.

show abstract

“…Interruptions, aberrancies, or prolongation in the process can lead to delayed wound healing or a nonhealing chronic wound. In adult humans, optimal wound healing involves the following the events: (1) rapid hemostasis; (2) appropriate inflammation; (3) mesenchymal cell differentiation, proliferation, and migration to the wound site; (4) suitable angiogenesis; (5) prompt re-epithelialization (re-growth of epithelial tissue over the wound surface); and (6) proper synthesis, cross-linking, and alignment of collagen to provide strength to the healing tissue (2,3) .…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study between the Combined Effect of Frankincense and Myrrh versus the Effect of Triamcinolone Acetonide on Healing of Induced Labial Mucosal Ulcer in Albino Rats

2017

View full text Add to dashboard Cite

Aim:The aim of the present study was to evaluate the combined effect of frankincense and myrrh versus the effect of triamcinolone acetonide (TA) on healing of induced labial mucosal ulcer in albino rats histologically and immunohistochemically. Materials and Methods: Seventy five adult male albino rats (weighting 200-250) were used in the study and exposed to induced ulcers in the labial mucosa. The rats were divided into four groups, positive control group, group I, and three experimental groups. Negative control group: group II: (received no treatment). Group III: ulcers were treated with triamcinolone acetonide three times daily. Group IV: ulcers were treated with combination of frankincence and myrrh three times daily. Histological, immunohistochemical examination (using cyclin D1) and statistical analysis were performed for all groups. The animals were sacrificed at day 1, 3 and day 7 postoperatively. Results: Frankincense and myrrh enhanced the healing of labial mucosal ulcer better than triamcinolone acetonide. Conclusion: This study showed that combination of frankincense and myrrh have superior healing properties on oral ulcer and enhancing cell proliferation compared to triamcinolone acetonide.

show abstract

Non-Healing Wounds

Cited by 98 publications

References 56 publications

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

Wound healing by marigold (Calendula officinalis) and turmeric (Curcuma longa) Paste: A comparative approach

CD98hc (SLC3A2) regulation of skin homeostasis wanes with age

A Comparative Study between the Combined Effect of Frankincense and Myrrh versus the Effect of Triamcinolone Acetonide on Healing of Induced Labial Mucosal Ulcer in Albino Rats

Contact Info

Product

Resources

About