A Comparative Study between the Combined Effect of Frankincense and Myrrh versus the Effect of Triamcinolone Acetonide on Healing of Induced Labial Mucosal Ulcer in Albino Rats

Wahba, Abeer; Farid, Mohamed; Adawy, Heba

doi:10.21608/adjg.2017.5281

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…The aqueous extract of the combination of frankincense and myrrh is widely used in clinics to obtain synergistically pain relief [17] and accelerate healing of oral ulcers [18].…”

Section: Since 2002mentioning

confidence: 99%

An Ex vivo Apoptotic and Cytotoxic Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Mostafa

El-Bolok

Fahmi

et al. 2022

Open Access Maced J Med Sci

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BACKGROUND: Oral squamous cell carcinoma is accounting for almost 90% of oropharyngeal cancer diagnoses. Natural herbal medicine can use as an alternative, or complementary, or adjunctive for cancer treatment. Frankincense and its combination with myrrh have anticancer effects on different cancer types. METHODS: In this research, aqueous and methanolic extracts of frankincense and the combination of aqueous extract of frankincense and myrrh were applied on tongue squamous cell carcinoma cell line to study their cytotoxic and apoptotic effect by the assessment of cell viability and cytotoxicity, caspase 3 and 8 activation, reactive oxygen species activity, mitochondrial membrane potential, morphological changes, and nuclear area factor measurements. RESULTS: The result showed that aqueous and methanolic extracts of frankincense have cytotoxic and apoptotic effects in a concentration-dependent manner with an IC50 value of 21.05 ± 1.27 μM for aqueous extract, 36.72 ± 2.07 μM for methanolic extract, and IC50 value of 1.31 ± 0.04 μM for combination of aqueous extract of frankincense and myrrh extract after 24 h. CONCLUSION: Different extracts of frankincense and the combination of aqueous extract of frankincense and myrrh extract exhibited cytotoxic and apoptotic effects by reducing the cell viability and activating caspases 3 and 8 causing intrinsic- and extrinsic-mediated apoptosis pathways activation with the involvement of oxidative stress that was conceivable with cytonuclear morphological alterations results.

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“…The aqueous extract of the combination of frankincense and myrrh is widely used in clinics to obtain synergistically pain relief [17] and accelerate healing of oral ulcers [18].…”

Section: Since 2002mentioning

confidence: 99%

An Ex vivo Apoptotic and Cytotoxic Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Mostafa

El-Bolok

Fahmi

et al. 2022

Open Access Maced J Med Sci

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“…In addition, the combination of frankincense and myrrh has been documented in the ancient Egyptian prescription collection of Papyrus Ebers as a treatment for wounds and skin ulcers [18]. And frankincense and myrrh in combination have superior healing properties on oral ulcer compared to triamcinolone acetonide [19].…”

Section: Introductionmentioning

confidence: 99%

Seeing the Unseen of the Combination of Two Natural Resins, Frankincense and Myrrh: Changes in Chemical Constituents and Pharmacological Activities

Cao

Wei

et al. 2019

Molecules

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For the treatment of diseases, especially chronic diseases, traditional natural drugs have more effective therapeutic advantages because of their multi-target and multi-channel characteristics. Among many traditional natural medicines, resins frankincense and myrrh have been proven to be effective in the treatment of inflammation and cancer. In the West, frankincense and myrrh have been used as incense in religious and cultural ceremonies since ancient times; in traditional Chinese and Ayurvedic medicine, they are used mainly for the treatment of chronic diseases. The main chemical constituents of frankincense and myrrh are terpenoids and essential oils. Their common pharmacological effects are anti-inflammatory and anticancer. More interestingly, in traditional Chinese medicine, frankincense and myrrh have been combined as drug pairs in the same prescription for thousands of years, and their combination has a better therapeutic effect on diseases than a single drug. After the combination of frankincense and myrrh forms a blend, a series of changes take place in their chemical composition, such as the increase or decrease of the main active ingredients, the disappearance of native chemical components, and the emergence of new chemical components. At the same time, the pharmacological effects of the combination seem magically powerful, such as synergistic anti-inflammation, synergistic anticancer, synergistic analgesic, synergistic antibacterial, synergistic blood-activation, and so on. In this review, we summarize the latest research on the main chemical constituents and pharmacological activities of these two natural resins, along with chemical and pharmacological studies on the combination of the two.

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Possible therapeutic effect of frankincense (Gum olibanum) and myrrh (Commiphora myrrha) resins extracts on DEN/CCL4 induced hepatocellular carcinoma in rats

Elmoslemany,

Elzallat,

Abd-Elfatah

et al. 2024

Phytomedicine Plus

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A Comparative Study between the Combined Effect of Frankincense and Myrrh versus the Effect of Triamcinolone Acetonide on Healing of Induced Labial Mucosal Ulcer in Albino Rats

Cited by 3 publications

References 16 publications

An Ex vivo Apoptotic and Cytotoxic Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

An Ex vivo Apoptotic and Cytotoxic Effects of Frankincense on Oral Squamous Cell Carcinoma Cell Line

Seeing the Unseen of the Combination of Two Natural Resins, Frankincense and Myrrh: Changes in Chemical Constituents and Pharmacological Activities

Possible therapeutic effect of frankincense (Gum olibanum) and myrrh (Commiphora myrrha) resins extracts on DEN/CCL4 induced hepatocellular carcinoma in rats

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