Non-functional C-cell Adenoma in Aged Horses

Ueki, Hideaki; Kowatari, Y.; Oyamada, Toshifumi; Oikawa, Masa-aki; Yoshikawa, Haruhisa

doi:10.1016/j.jcpa.2004.03.001

Cited by 36 publications

(48 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reported prevalence of thyroid adenoma is 75% in horses >20 years of age. 40 The prevalence of cardiac murmurs consistent with aortic or mitral valve regurgitation 17 was similar to the previously reported prevalence. 37 In the current study, cardiac valvular disease was noted at postmortem examination in only a few cases.…”

Section: Discussionsupporting

confidence: 87%

What’s New in Old Horses? Postmortem Diagnoses in Mature and Aged Equids

et al. 2015

View full text Add to dashboard Cite

Postmortem findings in 241 equids admitted to a teaching hospital that were at least 15 years old at autopsy were reviewed (1) to determine disease prevalence, (2) to compare the cause of death (or euthanasia) in equids 15 to 19 years of age (n ¼ 116) with that in equids 20 years of age (n ¼ 125), and (3) to catalog coexisting lesions in equids with pituitary pars intermedia dysfunction (PPID). Breed and sex were evenly distributed between the age groups. Death or euthanasia was attributed to disease of the digestive system (41.5%), pituitary gland (12.9%), locomotor system (10.0%), nervous system (7.9%), cardiovascular system (4.6%), urinary system (4.6%), reproductive system (4.2%), respiratory system (4.2%), integumentary system (4.2%), lymphoid system (2.5%), liver (2.5%), or systemic neoplasia (1.2%). Nervous system disease was more common in the 15-to 19-year group; urinary tract disease was more common in the 20-year group. Neoplastic disease, regardless of systemic location, was the basis for death or euthanasia in 18.7% of all equids. Squamous cell carcinoma, lymphoma, and melanoma were the most common malignant neoplasms. PPID was the most common specific diagnosis, based on the postmortem presence of hyperplasia or adenoma, and was the reason for euthanasia in 47.7% of 65 equids with PPID. The most common nonpituitary causes for death or euthanasia in equids with PPID were colic, lameness, cancer, and spinal cord disease. Coexisting conditions in equids with PPID that were not considered the basis for euthanasia included neoplasms, infections, lameness, and recurrent airway obstruction.

show abstract

Section: Discussionsupporting

confidence: 87%

What’s New in Old Horses? Postmortem Diagnoses in Mature and Aged Equids

et al. 2015

View full text Add to dashboard Cite

show abstract

“…11 Particular confusion surrounds the diagnosis and prevalence of primary hypothyroidism in adult horses. Thyroid disorders reported in the literature include nodular hyperplasia, 12 non-functional C-cell adenoma, [13][14][15] hyperthyroidism associated with thyroid neoplasia, [16][17][18] non-functional thyroid carcinoma, [19][20][21][22][23][24][25] idiopathic hypothyroidism 26 and…”

Section: Physiologymentioning

confidence: 99%

“…32 A more recent publication has described the incidence of non-functional C-cell adenomas in aged horses. 14 In this study immunohistochemical characterization of equine thyroid glands was performed using multiple primary antibodies to determine if lesions were of follicular Breeds included mostly thoroughbreds, 5 Anglo-arabs and one Draft horse. Four horses were of unknown breed.…”

Section: Physiologymentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Pertechnetate Thyroid Scintigraphy and the Ultrasonographic Appearance of the Thyroid Gland in Clinically Normal Horses

Davies

Barber

Crisman³

et al. 2010

Veterinary Radiology &Amp; Ultrasound

View full text Add to dashboard Cite

Abstract:The purpose of this study was to report the scintigraphic and sonographic appearance of the thyroid gland in clinically normal horses so these modalities could be used to assess the thyroid gland in this species. Horses were divided into two age groups. Group A consisted of 8 horses between 3 and 10 years of age and Group B of 7 horses between 11 and 20 years of age. Total T 4 concentrations were within the laboratory reference interval. Thyroid to salivary (T/S) ratio, percent dose uptake of pertechnetate and thyroid lobe volume were calculated. Echogenicity of thyroid lobes and presence of nodules were documented. The two groups were compared using appropriate parametric and nonparametic tests. Total T 4 concentrations were significantly lower in the older group. Sixty minute mean ± standard deviation (SD) T/S ratios for older versus younger horses were 5.8 ± 3.0 and 5.3 ± 2.2, respectively. Sixty minute median and interquartile ranges for percent dose uptake of pertechnetate for older versus younger horses were 3.64% (1.5 to 3.98%) and 2.55% (2.33 to 2.90%), respectively. Mean ± SD thyroid lobe volumes for older versus younger horses were 18.93 ± 5.16 cm 3 and 13.55 ± 3.56 cm 3 , respectively. Most thyroid lobes were hyper or isoechoic to the sternocephalicus muscle. Prevalence of thyroid nodules did not differ between groups. Older horses had trends for greater T/S ratios, percent dose uptakes and thyroid lobe volumes but had lower total T 4 concentrations. Further studies using scintigraphy and ultrasound in horses with thyroid disease are planned.

show abstract

“…Im Falle des Wallachs hatte die Grö-ßenzunahme der Umfangsvermehrung zu einer Beeinträchti-gung der Kehlkopfmotilität geführt; die Therapie der Wahl war daher -unabhängig von der Pathogenese -die mög-lichst vollständige chirurgische Exzision der Zubildung (Alberts et al 2000, Elce et al 2003, Thomaidis et al 2006, Papadogeorgakis et al 2009, Scharner und Kappe 2009 Gerade bei rapide wachsenden Umfangsvermehrungen im Bereich der Schilddrüse wie im Falle des Wallachs muss auch an einen Tumor der Schilddrüse gedacht werden. Tumoren der Schilddrüse treten jedoch in der Regel eher bei älteren Pferden auf (Dalefield und Palmer 1994, Knottenbelt 2003, Ueki et al 2004; dabei handelt es sich großteils um nichtfunktionale Adenome, so dass es außer einer oft nur einseitig vergrößerten Schilddrüse zu keinen weiteren klinischen Symptomen kommt (Lucke und Lane 1984, Yoshikawa et al 1984, Dalefield und Palmer 1994, Kuwamura et al 1998, Alberts et al 2000, Knottenbelt 2003, Ueki et al 2004, Scharner und Kappe 2009). Ein funktionell aktives Adenom geht mit Anzeichen eines Hyperthyreoidismus einher; dies konnte aufgrund des ungestörten Allgemeinbefindens sowie der im Normalbereich liegenden Blutwerte bereits vor der Operation mit großer Wahrscheinlichkeit ausgeschlossen werden (Ramirez et al 1998, Alberts et al 2000.…”

Section: Zervikale Lymphoepitheliale Zysteunclassified

Diagnosis and treatment of a lateral cervical cyst in a thoroughbred filly and in an 8 year-old Welsh-Cob gelding

Huthmann¹,

Toth²

2011

PHK

View full text Add to dashboard Cite

Non-functional C-cell Adenoma in Aged Horses

Cited by 36 publications

References 17 publications

What’s New in Old Horses? Postmortem Diagnoses in Mature and Aged Equids

What’s New in Old Horses? Postmortem Diagnoses in Mature and Aged Equids

Quantitative Pertechnetate Thyroid Scintigraphy and the Ultrasonographic Appearance of the Thyroid Gland in Clinically Normal Horses

Diagnosis and treatment of a lateral cervical cyst in a thoroughbred filly and in an 8 year-old Welsh-Cob gelding

Contact Info

Product

Resources

About