Non-excitatory electrical stimulation attenuates myocardial infarction via homeostasis of calcitonin gene-related peptide in myocardium

Guo, Zhijia; Guo, Zheng

doi:10.1016/j.peptides.2015.01.010

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…In sinus rhythm, the mean V OC,max , V OC,min , and the open-circuit voltage difference (ΔV OC ) from the Langendorff-perfused rat heart were 0.664 ± 0.109 mV, −0.546 ± 0.140 mV, 1.210 ± 0.233 mV respectively, which were just in the range of the non-excitatory electrical stimulation applied on rat heart (0.1 ~1 mV) (Supplementary Fig. 13A) 10 . When the heart rate was elevated to 420 b.p.m by 7 Hz pacing, all the V OC,max , V OC,min , and ΔV OC produce by TRI-TENG were increased correspondingly compared with those in sinus rhythm (Supplementary Fig.…”

Section: The Performance Of Tri-teng As the Energy Convertor In Vitro...mentioning

confidence: 94%

“…Inspired by the electroactive property of cardiac tissue, electrical stimulation (ES) is an agreeable approach to induce the CMs' maturation 8,9 , and even used to reduce the cardiac ischemic size after the ischemia-reperfusion injury elicited by an invasive electrode in the rat's ventricular wall 10 . Furthermore, the synergy of ES and conductive scaffolds can significantly improve cell-cell coupling and synchronous contraction of CMs, superior to the conductive scaffold itself 7 .…”

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confidence: 99%

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E-cardiac patch to sense and repair infarcted myocardium

Qiu,

Zhang,

Song

et al. 2024

Nat Commun

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Conductive cardiac patches can rebuild the electroactive microenvironment for the infarcted myocardium but their repair effects benefit by carried seed cells or drugs. The key to success is the effective integration of electrical stimulation with the microenvironment created by conductive cardiac patches. Besides, due to the concerns in a high re-admission ratio of heart patients, a remote medicine device will underpin the successful repair. Herein, we report a miniature self-powered biomimetic trinity triboelectric nanogenerator with a unique double-spacer structure that unifies energy harvesting, therapeutics, and diagnosis in one cardiac patch. Trinity triboelectric nanogenerator conductive cardiac patches improve the electroactivity of the infarcted heart and can also wirelessly monitor electrocardiosignal to a mobile device for diagnosis. RNA sequencing analysis from rat hearts reveals that this trinity cardiac patches mainly regulates cardiac muscle contraction-, energy metabolism-, and vascular regulation-related mRNA expressions in vivo. The research is spawning a device that truly integrates an electrical stimulation of a functional heart patch and self-powered e-care remote diagnostic sensor.

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Section: The Performance Of Tri-teng As the Energy Convertor In Vitro...mentioning

confidence: 94%

mentioning

confidence: 99%

E-cardiac patch to sense and repair infarcted myocardium

Qiu,

Zhang,

Song

et al. 2024

Nat Commun

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“…ES can be divided into excitatory electrical stimulation and non-excitatory electrical stimulation according to whether the action potential is generated after ES. Current studies have shown that non-excitatory electrical stimulation on the left ventricular wall of rats can reduce cardiac ischemia-reperfusion injury by reducing the expression of calcitonin gene-related peptide (CGRP) ( 26 ). With the development of ES, so far, there have been many forms.…”

Section: Overview Of Electrical Stimulationmentioning

confidence: 99%

Research Progress of Electrical Stimulation in Ischemic Heart Disease

Zhao

Wang

Chen³

et al. 2021

Front. Cardiovasc. Med.

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Ischemic heart disease (IHD) is a considerable health burden worldwide with high mortality and morbidity. Treatments for IHD are mainly focused on decreasing oxygen demand or increasing myocardial oxygen supply, including pharmacological, interventional, and surgical treatment, but there are also some limitations. Therefore, it is important to find a simple, effective, and economical treatment. As non-invasive and safe physiotherapy, electrical stimulation (ES) has a promising application in the treatment of IHD. Current studies suggest that ES can affect the occurrence and development of IHD by promoting angiogenesis, regulating autophagy and apoptosis, inhibiting the inflammatory response and oxidative stress. In this review, we focus predominantly on the mechanism of ES and the current progress of ES therapy in IHD, furthermore, give a brief introduction to the forms of ES in clinical application.

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