Non-epithelial tumors of the larynx: case series of 12 years

Saraydaroğlu, Özlem; Narter, Selin; Özşen, Mine; Çoşkun, Hakan

doi:10.1007/s00405-019-05527-0

Cited by 13 publications

(19 citation statements)

References 20 publications

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“…The failure of tight junctiontight junctions or tight junction proteins is one of the many key factors that contribute to the progression of cancer, but this is not a universal phenomenon as there can be many other direct or indirect factors that contribute to the development of cancer. The second reason that loss of tight junctions or tight junction proteins is not a universal phenomenon to the development of cancers is that besides the epithelial cancers, there are also non-epithelial tumors such as small subset of laryngeal neoplasms [11], angiomas, lipomas and neuromas [12] which do not display failure of tight junctions but other contributing factors come into play.…”

Section: Tight Junctionsmentioning

confidence: 99%

Claudin-1, A Double-Edged Sword in Cancer

Bhat

Syed

Therachiyil

et al. 2020

IJMS

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Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated and studied in a multitude of diseases. Claudins not only regulate paracellular transepithelial/transendothelial transport but are also critical for cell growth and differentiation. Not only tissue-specific but the differential expression in malignant tumors is also the focus of claudin-related research. In addition to up- or down-regulation, claudin proteins also undergo delocalization, which plays a vital role in tumor invasion and aggressiveness. Claudin (CLDN)-1 is the most-studied claudin in cancers and to date, its role as either a tumor promoter or suppressor (or both) is not established. In some cancers, lower expression of CLDN-1 is shown to be associated with cancer progression and invasion, while in others, loss of CLDN-1 improves the patient survival. Another topic of discussion regarding the significance of CLDN-1 is its localization (nuclear or cytoplasmic vs perijunctional) in diseased states. This article reviews the evidence regarding CLDN-1 in cancers either as a tumor promoter or suppressor from the literature and we also review the literature regarding the pattern of CLDN-1 distribution in different cancers, focusing on whether this localization is associated with tumor aggressiveness. Furthermore, we utilized expression data from The Cancer Genome Atlas (TCGA) to investigate the association between CLDN-1 expression and overall survival (OS) in different cancer types. We also used TCGA data to compare CLDN-1 expression in normal and tumor tissues. Additionally, a pathway interaction analysis was performed to investigate the interaction of CLDN-1 with other proteins and as a future therapeutic target.

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Section: Tight Junctionsmentioning

confidence: 99%

Claudin-1, A Double-Edged Sword in Cancer

Bhat

Syed

Therachiyil

et al. 2020

IJMS

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“…6-10 They are more frequent in males, and occur in supraglottic and glottic regions with the resultant symptoms being hoarseness, dysphagia, dysphonia, and shortness of breath. 1,6 Adult hemangiomas are not progressive tumors, but do not regress spontaneously either. 6 Treatment modalities range from conservative management for small tumors to systemic steroids, injection of corticosteroids or ethanol, surgical excision, cryosurgery, CO 2 laser excision and, rarely, radiation therapy for larger hemangiomas.…”

Section: Discussionmentioning

confidence: 99%

“…Mesenchymal tumors of the larynx are relatively uncommon, barring those of chondroid origin; vascular tumors are rare. 1 Anastomosing hemangioma (AH) is a relatively novel vascular neoplasm, first described in 2009. 2 Due to its non-lobular growth, anastomosing architecture and hobnail endothelial cells, it often mimics malignant vascular neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Anastomosing Hemangioma of the Larynx: A Unicorn among Head and Neck Tumors

Dutta

Kakkar

Sakthivel

et al. 2020

Ann Otol Rhinol Laryngol

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Objective: Anastomosing hemangioma (AH) is a novel tumor of vascular origin. Though well-documented in the kidney and retroperitoneum, only a single case has been documented in the head and neck, and AH in larynx has not been described. Methods: A 37-year-old male presented with difficulty in breathing, and hoarseness. Imaging revealed a lesion involving left paraglottic and cricothyroid spaces with destruction of cricoid cartilage, suggestive of a malignant cartilageneous neoplasm. Multiple biopsies were non-diagnostic. Results: Intraoperative frozen section during transcervical resection showed a vascular tumor devoid of nuclear atypia. Histopathological examination revealed a vasoformative tumor comprised of anastomosing capillary-sized vessels lined by flat and hobnail endothelial cells, consistent with AH. The patient was disease-free at 12 months. Conclusion: AH are rare neoplasms that may mimic a malignancy on imaging, especially in sites where they have not been documented. Due to their vascular nature, biopsies are often non-diagnostic, making preoperative diagnosis difficult. Frozen section may assist in decision-making on the extent of resection required.

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“…In regard to the larynx, ChS accounts for 1% of all laryngeal neoplasms[ 2 , 3 ]. Although these tumours rarely occur in the larynx, they have the second highest frequency after tumours originating from epithelial tissue, squamous cell carcinoma and adenocarcinoma[ 4 ]. Although high-grade ChS of the larynx has also been described, low-grade tumours are the most common form of the disease[ 1 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Low-grade chondrosarcoma of the larynx: A case report

Vučković¹,

Klisić²,

Filipović³

et al. 2021

WJCC

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BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline cartilage. Chondrosarcoma of the larynx, the most common type of low-grade tumour, accounts for 1% of all laryngeal neoplasms. CASE SUMMARY We present the case of a 60-year-old female patient who developed progressive hoarseness and shortness of breath over a 2-mo period. The patient had undergone resection of a laryngeal tumour 14 years before the aforementioned symptoms occurred, and histopathological analysis indicated that it was a chondroma. During the assessment of the patient, a submucosal, oval-shaped tumour was detected that was predominantly located on the left side of the larynx and was approximately 6 cm in size. The decision to perform left partial vertical laryngectomy was made. A pathohistological diagnosis of low-grade chondrosarcoma was made. Considering the results of pathohistological analysis and the positive margins of the resection, a total laryngectomy was performed. During the 12-mo follow-up, no local relapse or regional or distant metastases was detected. CONCLUSION Chondrosarcoma of the larynx must be considered in the differential diagnosis of laryngeal submucosal tumours. It is crucial to carefully sample of tumour tissue, differentiate chondroma and chondrosarcoma, and consider the possibility of malignant changes from chondroma to chondrosarcoma.

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Non-epithelial tumors of the larynx: case series of 12 years

Cited by 13 publications

References 20 publications

Claudin-1, A Double-Edged Sword in Cancer

Claudin-1, A Double-Edged Sword in Cancer

Anastomosing Hemangioma of the Larynx: A Unicorn among Head and Neck Tumors

Low-grade chondrosarcoma of the larynx: A case report

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