Low-grade chondrosarcoma of the larynx: A case report

Abstract

BACKGROUND Chondrosarcomas of the larynx are malignant tumours that most commonly originate from the hyaline cartilage. Chondrosarcoma of the larynx, the most common type of low-grade tumour, accounts for 1% of all laryngeal neoplasms. CASE SUMMARY We present the case of a 60-year-old female patient who developed progressive hoarseness and shortness of breath over a 2-mo period. The patient had undergone resection of a laryngeal tumour 14 years before the aforementioned symptoms occurred, and histopathological analysis indicated that it was a chondroma. During the assessment of the patient, a submucosal, oval-shaped tumour was detected that was predominantly located on the left side of the larynx and was approximately 6 cm in size. The decision to perform left partial vertical laryngectomy was made. A pathohistological diagnosis of low-grade chondrosarcoma was made. Considering the results of pathohistological analysis and the positive margins of the resection, a total laryngectomy was performed. During the 12-mo follow-up, no local relapse or regional or distant metastases was detected. CONCLUSION Chondrosarcoma of the larynx must be considered in the differential diagnosis of laryngeal submucosal tumours. It is crucial to carefully sample of tumour tissue, differentiate chondroma and chondrosarcoma, and consider the possibility of malignant changes from chondroma to chondrosarcoma.

Head and Neck Low Grade Chondrosarcoma—A Rare Entity

“…A summary of the main articles on head and neck chondrosarcoma is included in Table 1. We present the objective and type of study, results and conclusions [6][7][8][9][10][11][12][13][14][15]18,24]. The OS is 70% with a median follow-up of 3.5 years.…”

“…Sprekelsen et al mention the tumor grade as being associated with the risk of recurrence and with the profile of therapeutic failure. In the case of low-grade tumors, local growth is predominant, and for high-grade head and neck chondrosarcoma, distant metastasis becomes the predominant pattern of failure, even after years from the initial treatment [2,10,11].…”

Surgical Strategies and Outcomes for Intracranial Chondromas: A Retrospective Study of 17 Cases and Systematic Review

“…Uncalcified tissues are mostly composed of mesochondrium and cartilaginous stroma containing thin-walled blood vessels. Microscopic chondroma usually do not have cellular atypia or mitosis, whereas increased cellularity, infiltrative growth, cellular atypia, >20% myxoid changes, mitosis, and pleomorphism suggest chondrosarcoma ( 15 , 27 , 28 ). Chondromas are reported to be positive for vimentin and S-100 protein and chordomas for CK, EMA, S-100 protein, vimentin and brachyury; these are pathological discrimination indexes between these two types of tumors ( 4 , 15 ).…”