Non-enzymatic lactose molecularly imprinted sensor based on disposable graphite paper electrode

Silva, José Luiz da; Buffon, Edervaldo; Beluomini, Maísa Azevedo; Pradela‐Filho, Lauro A.; Araújo, Diele A.G.; Santos, André L.; Takeuchi, Regina M.; Stradiotto, Nelson Ramos

doi:10.1016/j.aca.2020.11.030

Cited by 49 publications

(14 citation statements)

References 44 publications

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“…Table S3 shows the electrochemical responses of the composites from the same batch were reproducible (RSD = 10%) since the sensitivities of the sensors were not significantly compromised by using different electrodes. RSD close to this estimated value was reported in the literature for other types of carbon composites, 1,8,26,45,46 demonstrating the proposed material has acceptable reproducibility. The batch‐to‐batch reproducibility was poorer (RSD = 15%).…”

Section: Resultssupporting

confidence: 85%

Low‐cost conductive films based on graphite and cellulose acetate as promising electroanalytical platforms

Paixão

Souza

Pradela‐Filho

et al. 2021

Polymers for Advanced Techs

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Conducting films were produced by incorporating 35, 50, and 60 wt.%. of graphite in cellulose acetate. The graphite contents showed to be of pivotal importance to the properties of the materials, mainly on the electrochemical performance. Thermal analyses indicated the graphite hinders the crystallization process of cellulose acetate and increases the hydrophobicity of the films. Scanning electron microscopy provided evidence of laminated graphite structures well‐dispersed in the polymeric matrix and exhibited a more porous aspect surface for the 50% G/Composite, which led to a higher surface area obtained by the N2 adsorption/desorption technique. This composite also had a better electrochemical response for ferrocyanide ion. The fabrication method was reproducible, which was associated with the structural uniformity of the resulting material. In addition, the conductive films are ready to use after production, precluding the need for any surface pretreatment. Moreover, the proposed sensor showed analytical potentiality for dopamine and hydroquinone determination, extending the possibilities for new electroanalytical applications.

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Section: Resultssupporting

confidence: 85%

Low‐cost conductive films based on graphite and cellulose acetate as promising electroanalytical platforms

Paixão

Souza

Pradela‐Filho

et al. 2021

Polymers for Advanced Techs

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“…S5A in Supporting Information). During the process, the anti-IgG molecules can be entrapped into the polymeric structure of PPy through molecular interactions probably between the hydroxyl groups of anti-IgG and the amine groups of PPy, and the interactions might contribute largely to the formation of the imprinted cavities [32]. Due to the increase in the thickness of the PPy film, the currents decrease with increasing cycling number.…”

Section: Electrodeposition Of Ppy As the Imprinting Layermentioning

confidence: 99%

A surface protein−imprinted biosensor based on boronate affinity for the detection of anti−human immunoglobulin G

et al. 2022

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A surface protein-imprinted biosensor was constructed on a screen-printed carbon electrode (SPCE) for the detection of anti-human immunoglobulin G (anti-IgG). The SPCE was successively decorated with aminated graphene (NH 2 -G) and gold nanobipyramids (AuNBs) for signal amplification. Then 4-mercaptophenylboric acid (4-MPBA) was covalently anchored to the surface of AuNBs for capturing anti-IgG template through boronate affinity binding. The decorated SPCE was then deposited with an imprinting layer generated by the electropolymerization of pyrrole. After removal of the anti-IgG template by the dissociation of the boronate ester in an acidic solution, three-dimensional (3D) cavities complementary to the anti-IgG template were formed in the imprinting layer of polypyrrole (PPy). The molecularly imprinted polymers (MIP)based biosensor was used for the detection of anti-IgG, exhibiting a wide linear range from 0.05 to 100 ng mL −1 and a low limit of detection of 0.017 ng mL −1 (S/N = 3). In addition, the MIP-based anti-IgG biosensor also shows high selectivity, reproducibility and stability. Finally, the practicability of the fabricated anti-IgG biosensor was demonstrated by accurate determination of anti-IgG in serum sample.

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“…For example, Kamel et al reported for the first time a simple and ultra-low-cost, disposable paper-based potentiometric sensor for determination of neutral BPA [83]. Paper substrates are accessible, flexible, recyclable and biodegradable, making them an attractive material for the preparation of electrochemical MIP sensors [83,84]. The sensors were built employing commercial chromatography paper, into which the synthetized BPA-MIP nanobeads were mixed with the PVC membrane cocktail and incorporated by dropcasting (Fig.…”

Section: Environmentalmentioning

confidence: 99%

“…Recently, da Silva et al reported the electropolymerization of a MIP on a disposable graphite paper electrode [84]. Concretely, towards the determination of lactose in milk samples (Fig.…”

Section: Food Controlmentioning

confidence: 99%

“…Sensing is based on the measurement of pore blockage with [FE(CN) 6 ] 3− upon rebinding of lactose when the sensor is incubated with the samples. Reproduced with permission from Elsevier [84] addition, the inherent redox activity of nitro-aromatic compounds makes them ideal candidates for electrochemical methods thanks to their multi-peak reduction signal [98]. In this regard, Leibl et al described the electropolymerization of two dummy MIPs for 2,4,6-trinitrotoluene (TNT) and RDX (1,3,5-trinitroperhydro-1,3,5-triazine) using trimesic acid and Kemp's triacid as structural analogues [41].…”

Section: Homeland Security and Forensicmentioning

confidence: 99%

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Molecularly imprinted polymers - towards electrochemical sensors and electronic tongues

2021

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Molecularly imprinted polymers (MIPs) are artificially synthesized materials to mimic the molecular recognition process of biological macromolecules such as substrate-enzyme or antigen-antibody. The combination of these biomimetic materials with electrochemical techniques has allowed the development of advanced sensing devices, which significantly improve the performance of bare or catalyst-modified sensors, being able to unleash new applications. However, despite the high selectivity that MIPs exhibit, those can still show some cross-response towards other compounds, especially with chemically analogous (bio)molecules. Thus, the combination of MIPs with chemometric methods opens the room for the development of what could be considered a new type of electronic tongues, i.e. sensor array systems, based on its usage. In this direction, this review provides an overview of the more common synthetic approaches, as well as the strategies that can be used to achieve the integration of MIPs and electrochemical sensors, followed by some recent examples over different areas in order to illustrate the potential of such combination in very diverse applications.

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Non-enzymatic lactose molecularly imprinted sensor based on disposable graphite paper electrode

Cited by 49 publications

References 44 publications

Low‐cost conductive films based on graphite and cellulose acetate as promising electroanalytical platforms

Low‐cost conductive films based on graphite and cellulose acetate as promising electroanalytical platforms

A surface protein−imprinted biosensor based on boronate affinity for the detection of anti−human immunoglobulin G

Molecularly imprinted polymers - towards electrochemical sensors and electronic tongues

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