Non-enhancing primary CNS lymphoma

Lachenmayer, M. Lenard; Blasius, Elias; Niehusmann, Pitt; Kovács, Attila; Stuplich, Moritz; Eichler, Oskar; Glas, Martin; Urbach, Horst; Herrlinger, Ulrich

doi:10.1007/s11060-010-0258-x

Cited by 16 publications

(12 citation statements)

References 3 publications

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“…This was also found in other studies, where only 10% of untreated lesions were unenhanced [2] (1% in immunocompetent patients [9,25] ). This percentage increases for post-transplant immunodeficient patients [26] .…”

Section: Mri Featuressupporting

confidence: 86%

Findings at presentation in primary CNS diffuse large B-cell lymphoma of the brain: A comparison of immunocompetent and immunodeficient patients

Sampedro

Corroto²,

Arias³

et al. 2013

JBGC

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Background/Objectives: Primary central nervous system lymphoma (PCNSL) is a rare tumour with poor prognosis. Due to the increased number of patients with PCNSL over the past two decades our purpose are to describe magnetic resonance imaging (MRI) and Computed Tomography (CT) findings in (PCNSL) of the brain, and to study the differences between immunocompetent and immunodeficient patients with PCNSL. Methods:A retrospective, descriptive study was performed with 59 patients diagnosed of PCNSL in two hospitals from 1997 to 2010. Immunocompetent (n=38) and immunodeficient (n=21) patients were compared and differences between both groups were analyzed. Patients were evaluated according to sex, age, median time from clinical symptoms presentation to pathologic diagnosis, clinical symptoms, location, number of lesions, size, MRI and CT characteristics. Significance was defined as p < 0.05.Results: MRI findings: 50% of lesions in immunocompetent and 52.4% in immunodeficient group were heterogeneous, 89.5% of lesions in immunocompetent and 85,7% in immunodeficient were hypo-isointense on T1WI; 63.2% of lesions in immunocompetent and 76.2% in immunodeficient group were hyperintense on T2WI. CT images: 48.39% of lesions in immunocompetent and 20% in immunodeficient group were hyperdense. Statistically significant differences between immunocompetent and immunodeficient patients were found when evaluating the age (p < 0.000) and median time from clinical symptoms presentation to pathologic diagnosis (p < 0.008).Conclusions: MRI and CT are able to define imaging characteristics of PCNSL, promoting a quick diagnosis. There are no significant differences between immunocompetent and immunodeficient patients for MR and CT features.

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Section: Mri Featuressupporting

confidence: 86%

Findings at presentation in primary CNS diffuse large B-cell lymphoma of the brain: A comparison of immunocompetent and immunodeficient patients

Sampedro

Corroto²,

Arias³

et al. 2013

JBGC

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“…Nonenhancing PCNSLs were considered to be low-grade PCNSLs, less aggressive than typical PCNSLs in some previous studies. 8,30 An autopsy report of a patient with PCNSL suggested that only scattered infiltration of malignant lymphomatous cells was observed in the nonenhancing tumor portion. 29 Therefore, we speculate that the low cellularity and low invasiveness contributed to the nonspecific MR spectrum in those cases.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6] However, some patients present with atypical MR imaging features, commonly those of heterogeneous enhancement, such as patchy enhancement, streaky enhancement without mass formation, or even no enhancement. [6][7][8][9] Demyelinating diseases of the CNS are pathologic entities that are frequently encountered in clinical practice. When such lesions appear as solitary masses Ͼ2 cm in the longest diameter, they are defined as tumefactive demyelinating lesions (TDLs), and they can cause symptoms mimicking brain neoplasms and can be associated with variable enhancement on MR imaging.…”

mentioning

confidence: 99%

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Kim

et al. 2013

American Journal of Neuroradiology

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“…Another sign that could have lead to a diagnosis of lymphoma was the subtle area of contrast enhancement. Most notably, IVL and lymphoma of the brain may present as only slightly contrast-enhancing or even nonenhancing brain lesions [3,6,19]. Finally, only autopsy resulted in the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Fulminant intravascular lymphomatosis mimicking acute haemorrhagic leukoencephalopathy

Marino

Sicurelli

Cerase

et al. 2012

Journal of the Neurological Sciences

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Non-enhancing primary CNS lymphoma

Cited by 16 publications

References 3 publications

Findings at presentation in primary CNS diffuse large B-cell lymphoma of the brain: A comparison of immunocompetent and immunodeficient patients

Findings at presentation in primary CNS diffuse large B-cell lymphoma of the brain: A comparison of immunocompetent and immunodeficient patients

Utility of Proton MR Spectroscopy for Differentiating Typical and Atypical Primary Central Nervous System Lymphomas from Tumefactive Demyelinating Lesions

Fulminant intravascular lymphomatosis mimicking acute haemorrhagic leukoencephalopathy

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