Non-Cross-Linked Collagen Mesh Performs Best in a Physiologic, Noncontaminated Rat Model

Abstract

Background . In laparoscopic incisional hernia repair, direct contact between the prosthesis and abdominal viscera is inevitable and may lead to adhesions. Despite the large variety of mesh prosthesis, little is known about their in vivo behavior. Biological meshes are considered to have many advantages, but due to their price they are rarely used. A rat model was used to assess biological and conventional synthetic meshes on their in vivo characteristics. Design . One-hundred twenty male Wistar rats were randomized into five groups of 24 rats. A mesh was implanted intraperitoneally and fixated with nonresorbable sutures. The following five meshes were implanted: Parietene (polypropylene), Permacol (cross-linked porcine acellular dermal matrix), Strattice (non-cross-linked porcine acellular dermal matrix), XCM Biologic (non-cross-linked porcine acellular dermal matrix), and Omyra Mesh (condensed polytetrafluoroethylene). The rats were sacrificed after 30, 90, or 180 days. Incorporation, shrinkage, adhesions, abscess formation, and histology were assessed for all meshes. Results . All animals thrived postoperatively. After 180 days, Permacol, Parietene, and Omyra Mesh had a significantly better incorporation than Strattice ( P = .001, P = .019, and P = .037 respectively). After 180 days, Strattice had significantly fewer adhesions on the surface of the mesh than Parietene ( P < .001), Omyra Mesh ( P = .011), and Permacol ( P = .027). After 30 days, Permacol had significantly stronger adhesions than Strattice ( P = .030). However, this difference was not significant anymore after 180 days. After 180 days, there was significantly less shrinkage in Permacol than in Strattice ( P = .001) and Omyra Mesh ( P = .050). Conclusion . Based on incorporation, adhesions, mesh shrinkage, and histologic parameters, Strattice performed best in this experimental rat model.

XCM Biologic Tissue Matrix xenograft and autologous micromucosa graft for vaginal reconstruction in Mayer-Rokitansky-Küster-Hauser syndrome

“…XCM Biologic Tissue Matrix has been mainly used in thoracic surgery [ 8 - 10 ], and there have been some in vivo studies in rabbits regarding its use in abdominal wall reconstruction, namely in ventral hernia repair [ 11 ]. Kaufmann et al [ 12 , 13 ] performed experimental studies in rats regarding incisional hernia repair with biological meshes. Their study, using a peritonitis model, suggested that XCM Biologic Tissue Matrix was superior to other meshes in terms of incorporation, macroscopic mesh infection, and histological parameters including neovascularization and collagen deposition.…”

“…The authors also advised overlapping the mesh to overcome the moderate shrinkage rate of XCM Biologic Tissue Matrix [ 12 ]. They also noted that this biomaterial had a much higher incorporation rate in a contaminated environment than in a physiological non-contaminated environment, suggesting this could be due to a higher fulminant inflammatory response [ 13 ].…”

Current Insights into Collagen Type I

“…Col-I, which is modified in the form of a gel, can be used as an injectable material. In this scenario, the injection of Col-I gel into the spine system enables exons to arise from the interface and then grow into the implanted Col gel within a short duration [ 58 ]. Apart from this, Col-I modulated into the microsphere is known to be the perfect biomaterial for the deliverance and regeneration of neural and neural progenitor cells [ 59 ].…”

Reinforced Biologic Mesh Reduces Postoperative Complications Compared to Biologic Mesh after Ventral Hernia Repair

“…Examples include noncross-linked porcine ADM (NC-PADM), cross-linked porcine dermal biologic mesh (C-PADM), and fetal bovine ADM (BADM). 6 , 7 Recently, a hybrid biologic and synthetic (biosynthetic) mesh has been developed, which is composed of both biologic and synthetic components. This mesh consists of ovine rumen reinforced with interwoven propylene [reinforced biologic ovine rumen (RBOR)].…”