Non-covalent π–π functionalized Gii-senseⓇ graphene foam for interleukin 10 impedimetric detection

Frías, Isaac A.M.; Zine, Nadia; Sigaud, Monique; Lozano-Sánchez, Pablo; Caffio, Marco; Errachid, Abdelhamid

doi:10.1016/j.bios.2022.114954

Cited by 11 publications

(6 citation statements)

References 27 publications

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“…In addition, recent progress in nanomaterial-based electrochemical biosensors for the detection of interleukins has also been reviewed [ 49 ]. A recent example of electrochemical biosensors for ILs related to IBD is the impedimetric immunosensor reported by Frias et al [ 50 ] for IL-10, an interleukin secreted in patients at the early stage of inflammation. The biosensor involves the fabrication of a microfluidic lab-on-chip device using graphene-foam flexible electrodes functionalized with pyrene carboxylic acid by π complexation, and the covalent immobilization of the anti-IL-10 antibodies.…”

Section: Gastrointestinal Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Sánchez‐Tirado

Agüı́

González‐Cortés

et al. 2023

Sensors

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The study of the human microbiome is a multidisciplinary area ranging from the field of technology to that of personalized medicine. The possibility of using microbiota biomarkers to improve the diagnosis and monitoring of diseases (e.g., cancer), health conditions (e.g., obesity) or relevant processes (e.g., aging) has raised great expectations, also in the field of bioelectroanalytical chemistry. The well-known advantages of electrochemical biosensors—high sensitivity, fast response, and the possibility of miniaturization, together with the potential for new nanomaterials to improve their design and performance—position them as unique tools to provide a better understanding of the entities of the human microbiome and raise the prospect of huge and important developments in the coming years. This review article compiles recent applications of electrochemical (bio)sensors for monitoring microbial metabolites and disease biomarkers related to different types of human microbiome, with a special focus on the gastrointestinal microbiome. Examples of electrochemical devices applied to real samples are critically discussed, as well as challenges to be faced and where future developments are expected to go.

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Section: Gastrointestinal Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Sánchez‐Tirado

Agüı́

González‐Cortés

et al. 2023

Sensors

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“…IL-6 was detected in fg ml −1 by utilizing these two properties using a porous graphene working electrode functionalized with IL-6 antibody to reach LOD of 7.9 fg ml −1 and LOQ in the range of 10-100 fg ml −1 in artificial saliva. 46 The electronic properties of graphene enabled its use in FET biosensors as well. An aptamer-functionalized graphene FET was also used in the detection of IL-6 biomarker via single-step functionalization of the graphene FET channel by using pyrenetagged DNA aptamers (PTDA) to overcome the use of organic solvents such as dimethyl formamide (DMF) or dimethyl sulfoxide (DMSO) which may affect the integrity of the biosensor by damaging microchannels and cross-linked layers.…”

Section: Carbon-based Materialsmentioning

confidence: 99%

Review—Electrochemical Biosensors for Interleukins: Electrode Materials

Yahia

Tawfik

Fritzsche

et al. 2023

J. Electrochem. Soc.

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Interleukins gained great interest as potential biomarkers for autoimmune diseases, cancers, and viral infections. Challenges faced in the detection of interleukins include their minute concentrations in biological specimens, the need to generate quantitative results, and multi-analyte measurement for differential diagnosis. The properties of the material of the working electrode are crucial for signal transduction. Consequently, different working electrode materials were investigated to select the ones which generate the highest signal and ensure the reproducibility of the results and the robustness of the biosensor. In this review, the interleukin electrochemical biosensors developed since 2015 were classified according to the material of the working electrode into noble metals, ceramics, and carbon-based materials. The advantages and limitations of each working electrode material are discussed. Designs and performance criteria of interleukin electrochemical biosensors developed since 2015 are compared with reference to the type of working electrode material including those made of hybrid ones.

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“…In addition, recent progress in nanomaterials-based electrochemical biosensors for the detection of interleukins has also been reviewed [47]. A recent example of electrochemical biosensors for ILs related to IBD is the impedimetric immunosensor reported by Frias et al [48] for IL-10, an interleukin secreted in patients at the early stage of inflammation. The biosensor involves the fabrication of a microfluidic lab-on-chip device using graphene foam flexible electrodes functionalized with pyrene carboxylic acid by π complexation, and the covalent immobilization of the anti-IL-10 antibodies.…”

Section: Gastrointestinal Microbiomementioning

confidence: 99%

Electrochemical (Bio)Sensing Devices for Human Microbiome Related Biomarkers

Sánchez‐Tirado¹,

Agüı́²,

González‐Cortés³

et al. 2022

Preprint

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The study of the human microbiome is a multidisciplinary area that affects from the field of technology to that of personalized medicine. The possibility of using microbiota biomarkers for the improvement in the diagnosis and monitoring of diseases (e.g. cancer), health conditions (e.g. obesity) or clinical parameters (e.g. ageing) has aroused great expectations, also in the scope of bio-electroanalytical chemistry. The well-known advantages of electrochemical transduction: high sensitivity, rapid response and possibility of miniaturization, together with the potential of new nanomaterials to improve both the design of electrode platforms and the performance of the resulting electrochemical biosensors make presumably a huge development in the next few years providing a better understanding of human microbiome entities. In this review article, the recent applications of electrochemical (bio)sensors for monitoring microbial metabolites and biomarkers of diseases related to different types of the human microbiome, with a special focus on the gastrointestinal microbiome, are reviewed. Examples of electrochemical devices applied to real samples are critically discussed as well as the challenges and prospects to be faced.

show abstract

Non-covalent π–π functionalized Gii-senseⓇ graphene foam for interleukin 10 impedimetric detection

Cited by 11 publications

References 27 publications

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Electrochemical (Bio)Sensing Devices for Human-Microbiome-Related Biomarkers

Review—Electrochemical Biosensors for Interleukins: Electrode Materials

Electrochemical (Bio)Sensing Devices for Human Microbiome Related Biomarkers

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