Non-coding Single Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population

Akther, Jobaida; Das, Ashish; Rahman, Atikur; Saha, Sajoy Kanti; Hosen, Ismail; Ebihara, Akio; Nakagawa, Tsutomu; Suzuki, Fujio; Nabi, Ahm Nurun

doi:10.1007/s10528-021-10049-8

Cited by 4 publications

(1 citation statement)

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“…Previous studies have shown that patients with hypertension and DM have a higher incidence of renal dysfunction than patients with either hypertension or DM alone ( 4 , 5 ), suggesting higher risk for CKD in patients with coexistent hypertension and DM. Hypertension and DM are both heterogeneous polygenic genetic diseases, and their common familial aggregation and sequential coexistence are very high ( 6 , 7 ), indicating that they may have a common pathogenesis. The main and core comorbidity mechanisms are insulin resistance (IR) ( 8 , 9 ).…”

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confidence: 99%

The non-linear relationship between triglyceride-glucose index and risk of chronic kidney disease in hypertensive patients with abnormal glucose metabolism: A cohort study

et al. 2022

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BackgroundTriglyceride–glucose (TyG) index has been reported to be associated with cardiovascular disease (CVD). However, few studies have focused on TyG index and the risk of chronic kidney disease (CKD). Thus, this study aims to explore the relationship between TyG index and CKD.MethodsA total of 2,033 participants with hypertension between January 2012 and May 2019 were included in the longitudinal observational study. All patients are grouped according to the TyG index quartile. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min per 1.73 m2 and/or positive proteinuria. Multivariate Cox proportional hazards models were used to investigate the relationship between TyG index and CKD.ResultsDuring a median follow-up of 31 months, 302 participants developed CKD, with a mean age of 55.5 years and median TyG of 8.94. Compared with those in the lowest quartile of TyG index, participants in the highest quartile of TyG index exhibited 1.63-fold higher hazard ratio (95% CI: 1.14–2.33, P = 0.007) for presence of CKD. And restricted cubic spline analysis showed the relationship between TyG index and CKD is non-linear (P non-linearity = 0.021). The hazard ratio for CKD first fell and after rising until around 8.94 of TyG index and started to increase rapidly afterward (P for TyG < 0.001).ConclusionHigher TyG index is associated with the increased risk for CKD. Early intervention of metabolic factors may prevent the occurrence of CKD, thereby reducing the incidence of CVD and premature death.

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