Non-coding RNAs regulate mitochondrial dynamics in the development of gastric cancer

Abstract

Gastric cancer (GC) is a malignant cancer that reduces life expectancy worldwide. Although treatment strategies have improved, patients with GC still have poor prognoses. Hence, it is necessary to understand the molecular mechanisms of GC and to find new therapeutic targets. Mitochondrial dynamics and mitochondrial dysfunction are associated with cancer cell growth and progression. Numerous studies have reported that non-coding RNAs (ncRNAs) can participate in the occurrence and development of GC by regulating mitochondrial dynamics. Elucidating the crosstalk between ncRNAs and mitochondria would be helpful in preventing and treating GC. Herein, we review and summarize the functions of oncogenes and tumor suppressors in suppressing ncRNAs and regulating mitochondrial dynamics in GC tumor growth, proliferation, invasion and metastasis. This review provides new insights into the pathogenesis of and intervention for GC.

Andrographolide reverts multidrug resistance in KBChR 8‐5 cells through AKT signaling pathway

“…The paclitaxel (PTX) and doxorubicin (DOX) are major chemotherapeutic drugs approved by the Food and Drug Administration (FDA) 25–27 . PTX and DOX induce apoptosis via arrest of mitosis by stabilization of microtubule and disruption of topoisomerase‐II mediated DNA repair 28–30 . However, their efficacy is limited due to the development of MDR in cancer cells.…”